王樹

2002–2008年於中國科學技術大學神經生物和生物物理學系獲博士學位；2008-2012年赴美國康奈爾大學生物醫學系進行博士後研究；2012年進入中國科學院昆明動物研究所任副研究員，2017年起任研究員，博士生導師；現於廣州醫科大學基礎醫學院任教授、博士生導師。

主要研究方向為神經藥理學，使用分子生物學、電生理記錄、神經元培養及活細胞熒光成像、轉錄組和蛋白質組分析技術以及疾病動物模型，去解析外周神經系統相關疾病的分子機制，尋找疾病治療的新靶點，並在此基礎上進行活性分子及傳統中藥有效成分的篩選、藥理學研究和臨牀實驗。其研究成果以第一或通訊作者發表在Nature、PNAS、EMBO系列等SCI雜誌上，並主持多項國家及地方科研基金項目，合計經費超過600萬元。 ^[1] 

1.Shao Y,Tian HY,Zhang JJ,Kharrati-Koopaee H,Guo X,Zhuang XL,Li ML,Nanaie HA,Dehghani Tafti E,Shojaei B,Reza Namavar M,Sotoudeh N,Adeola Oluwakemi A,Li JL,Liang B,Esmailizadeh A,Shu Wang*,Wu DD*.Genomic and phenotypic analyses reveal mechanisms underlying homing ability in pigeon.Mol Biol Evol. 2019 Sep 10. (影響因子14.797)*共同通訊作者

2.Shu Wang*，Dan Zhang, Jinsheng Hu, Qi Jia, Wei Xu, Deyuan Su, Hualing Song, Zhichun Xu, Jianmin Cui, Ming Zhou, Jian Yang*, Jianru Xiao*. A clinical and mechanistic study of topical borneol-induced analgesia. EMBO molecular medicine 2017 Apr 10.(影響因子10.624)*第一兼通訊作者

3. Deyuan Su, Yin Nian, Fenglei Zhang, Jinsheng Hu, Jianmin Cui, Ming Zhou, Jian Yang*,Shu Wang*.Thiazolidine reacts with thioreactive biomolecules. Free Radical Biology & Medicine 2017 Mar;104:272-279 (影響因子5.606)*通訊作者

4. Minghui Li, Xiaoyuan Zhou,Shu Wang, IoannisMichailidis, Ye Gong, Deyuan Su, Huan Li, Xueming Li* & Jian Yang*. Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature 2017 Feb 2;542(7639):60-65. (影響因子40.137)共同第一作者

5.Deyuan Su, Hong Zhao, Jinsheng Hu, Dan Tang, Jianmin Cui, Ming Zhou, Jian Yang*,Shu Wang*. TRPA1 and TRPV1 contribute to iodine antiseptics-associated pain and allergy. EMBO Reports 2016 Oct;17(10):1422-1430. (影響因子8.568)*通訊作者

6.Shu Wang, Huai-hu Chuang. C-terminal Dimerization Activates the Nociceptive Transduction Channel Transient Receptor Potential Vanilloid 1. Journal of Biological Chemistry 2011 Nov 25; 286(47): 40601–40607. (影響因子4.773)第一作者

7. Elaine Wang, Hui Li,Shu Wang, Alexander Y Chuang, and Huai-huChuang.Induction of TRPV1 desensitization by a biased receptor agonist. Channels (Austin) 2011 Nov-Dec;5(6):464-7. (影響因子2.140)共同第一作者

8.Hui Li,Shu Wang, Alexander Y. Chuang, Bruce E. Cohen, and Huai-hu Chuang. Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proceedings of the National Academy of Sciences. 2011 May 17;108(20):8497-502 (影響因子9.681)共同第一作者

9.Shu Wang, Kinning Poon, Robert Oswald, and Huai-hu Chuang. Distinct Modulations of Human Capsaicin Receptor by Protons and Magnesium through Different Domains. Journal of Biological Chemistry 2010 Apr 9; 285(15): 11547–11556. (影響因子5.328)第一作者

10.Shu Wang, Tai-Ran Xing, Ming-Liang Tang, Wu Yong, Chen-Chen Li, Di-Yun Ruan. Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Naunyn-Schmiedebergs Archives of Pharmacology 2008 May;377(3):245-53. (影響因子2.830)第一作者

11.Shu Wang, Pu Hu, Hui-Li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Effects of Cd2+ on AMPA receptor-mediated synaptic transmission in rat hippocampal CA1 area. Toxicology Letters 2008 Feb 15;176(3):215-22. (影響因子3.249)第一作者

12.Shu Wang, Yan Gu, Hui-Li Wang, Xin-Mei Li, Ming Wang, Li-Guang Sun, Di-Yun Ruan. Inhibitory effect of Cd2+ on glycine-induced chloride current in rat hippocampal neurons. Brain Research Bulletin 2006 May 31;69(6):680-6. (影響因子1.684)第一作者

13. Hao Sun, Hui-Li Wang,Shu Wang*. d-serine relieves chronic lead exposure-impaired long-term potentiation in the CA1 region of the rat hippocampus in vitro. Neuroscience Letter 2007 Mar 1; 417(2): 118-22. (影響因子2.085)*通訊作者

14. Minghui Li, Wei K Zhang, Nicole M Benvin, Xiaoyuan Zhou, Deyuan Su, Huan Li,Shu Wang, Ioannis E Michailidis, Liang Tong, Xueming Li & Jian Yang*. Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel. Nature Structural & Molecular Biology 2017 Mar;24(3):205-213. (影響因子12.595)

15. Ahmed,Shu Wang, Huai-Hu Chuang, and Robert Oswald. Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations. Journal of Biological Chemistry 2011 Oct 7;286(40):35257-66. (影響因子4.773)

16. Wu Yong, Min-Min Zhang,Shu Wang, Di-Yun Ruan. Effects of sodium valproate on synaptic transmission and neuronal excitability in rat hippocampus. Clinical and Experimental Pharmacology and Physiology 2009 Nov;36(11):1062-7. (影響因子1.936)

17. Wu Yong, Tai-Ran Xing,Shu Wang, Liang Chen, Pu Hu, Chen-Chen Li, Hui-li Wang, Ming Wang, Ju-Tao Chen, Di-Yun Ruan. Protective Effects of Gastrodin on Lead-Induced Synaptic Plasticity Deficits in Rat Hippocampus. Planta Medica 2009 Aug;75(10):1112-7. (影響因子2.037)

18. Hui-Li Wang, Xiang-Tao Chen, Bin Yang, Fang-Li Ma,Shu Wang, Ming-Liang Tang, Ming-Gao Hao, and Di-Yun Ruan. Case-control study of blood lead levels and attention deficit hyperactivity disorder in Chinese children. Environmental Health Perspectives 2008 Oct;116(10):1401-6. (影響因子6.123)

19. Pu Hu, Lei Sun, Zhi-Qiang Zhu, Xiao-Wei Hou,Shu Wang, Shan-Shan Yu, Hui-Li Wang, Ping Zhang, Ming Wang, Li-Wen Niu, Mai-Kun Teng, Di-Yun Ruan. Crystal structure of Natratoxin, a novel snake secreted phospholipasesA2 neurotoxin from Najaatra Venom inhibiting A-type K+ currents. Proteins-Structure, Function, and Bioinformatics 2008 Aug;72(2):673-83. (影響因子3.419)

20.Zhi-Dian Niu, Ju-Tao Chen,Shu Wang, Ming Wang, Xin-Mei Li and Di-Yun Ruan. Inhibition of delayed rectifier K+ currents by copper in acutely dissociated rat hippocampal CA1 neurons. Toxicology Letters 2006 Sep 10;165(3):289-96. (影響因子2.784)

21. Hui-Li Wang, Xiang-Tao Chen, Le Luo, Zhi-Yi Lou,Shu Wang, Ju-Tao Chen, Ming Wang, Li-Guang Sun and Di-Yun Ruan. Reparatory effects of nicotine on NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 region of chronically lead-exposed rats. European Journal of Neuroscience 2006 Mar;23(5):1111-9. (影響因子3.709) ^[1]