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王本

（浙江大學教授）

鎖定
王本，浙江大學醫學院附屬第二醫院、轉化醫學研究院教授。
中文名
王本
職    稱
浙江大學教授

目錄

  1. 1 研究方向
  2. ▪ 可視細胞表面過程
  3. ▪ 可控細胞表面功能
  1. ▪ 可創造新型細胞
  2. 2 相關實驗技術
  3. 3 轉化醫學潛力
  1. 4 代表性論著

王本研究方向

細胞表面化學生物學即採用化學手段在細胞表面引入外源性化學小分子或者材料大分子以調節細胞功能和識別生物材料，它有望嫁接生命和非生命體系，從分子層次調控細胞-材料表界面發展疾病的精準診療策略，是化學、生物學和醫學交叉融合的新興研究方向。 [1] 

王本可視細胞表面過程

化學修飾細胞表面以識別和干預腫瘤細胞，提出癌症診療新思路（Angew. Chem. Int. Ed., 2021, 60(12), 6509-6517；Adv. Funct. Mater., 2021, 31(27), 2101284）。

王本可控細胞表面功能

化學修飾細胞表面以賦予細胞新功能，構建細胞治療新載體（Adv. Sci., 2021, 8(3), 2003348；ACS Nano, 2019, 13(2), 1910–1922）。

王本可創造新型細胞

化學修飾細胞表面以掩蔽血型抗原，構建新型通用紅細胞（Sci. Adv., 2020, 6(12): eaaw9679；Chem. Sci., 2014, 5(9), 3463-3468）。

王本相關實驗技術

化學合成與表徵；生物化學與分子生物學技術；微流控；電子顯微鏡；細胞培養；動物模型（小鼠、大鼠或靈長類） [1] 

王本轉化醫學潛力

癌症早期診斷工具和個性化治療手段；細胞工程與細胞治療。 [1] 

王本代表性論著

  1. Jicheng Wu, Xudong Wang, Yuqiao Huang, Siyu Su, Hao Shou, Haoran Wang, Jin Zhang, and Ben Wang*. Targeted Glycan Degradation Potentiates Cellular Immunotherapy for Solid Tumors. PNAS. 2023, 120(38), e2300366120. (IF 11.1)
  2. Qingyan Zhang, Pengkai Wu, Jicheng Wu, Hao Shou, Xinliang Ming, Shuqi Wang, and Ben Wang*. Chemoimmunological Cascade Cancer Therapy Using Fluorine Assembly Nanomedicine. ACS Nano. 2023, 17(8), 7498-7510. (IF 15.9)
  3. Ning Tang, Hanhui Li, Lihong Zhang, Xueyun Zhang, Yanni Chen, Hao Shou, Shuaishuai Feng, Xinhua Chen, Yan Luo, Ruikang Tang*, and Ben Wang*. A macromolecular drug for cancer therapy via extracellular calcification. Angewandte Chemie International Edition, 2021, 60(12), 6509-6517. (Cover Picture, IF 15.3)
  4. Kaixin Zhang#, Jicheng Wu#, Xiaoxiong Zhao, Jiale Qin, Yi Xue, Weizeng Zheng, Lixiu Wang, Haoran Wang, Hong Shen, Tianye Niu, Yan Luo, Ruikang Tang, and Ben Wang*. Prussian Blue/Calcium Peroxide Nanocomposites-Mediated Tumor Cell Iron Mineralization for Treatment of Experimental Lung Adenocarcinoma. ACS Nano. 2021, 15(12), 19838–19852. (IF 15.9)
  5. Jicheng Wu#, Yanni Chen#, Jinxia Xin, Jiale Qin, Weizeng Zheng, Shuaishuai Feng, Chongran Sun, Mei Tian, Zhimin Lu, Ben Wang*. Bioinspired tumor calcification enables early detection and elimination of lung cancer. Advanced Functional Materials, 2021, 31(27), 2101284. (IF 18.8)
  6. Ling Zhang, Guowu Liu, Kaiqi Lv, Jinxia Xin, Yingchao Wang, Jing Zhao, Wangxing Hu, Changchen Xiao, Keyang Zhu, Lianlian Zhu, Jinliang Nan, Ye Feng, Huaying Zhu, Wei Chen, Wei Zhu, Jianyi Zhang, Jian’an Wang, Ben Wang*, and Xinyang Hu*. Surface-anchored nanogel coating endows stem cells with stress resistance and reparative potency via turning down the cytokine-receptor binding pathways. Advanced Science, 2021, 8(3), 2003348. (IF 16.8)
  7. Yueqi Zhao, Mingjie Fan, Yanni Chen, Zhaoming Liu, Changyu Shao, Biao Jin, Xiaoyu Wang, Lanlan Hui, Shuaifei Wang, Zhaoping Liao, Daishun Ling, Ruikang Tang*, Ben Wang*. Surface-anchored framework for generating RhD-epitope stealth red blood cells. Science Advances, 2020, 6(12): eaaw9679. (IF 14.1)
  8. Chuanjiang He, Tingting Ye, Wenqi Teng, Zhi Fang, Wei-Shuyi Ruan, Guowu Liu, Hui Chen, Jizeng Sun, Lanlan Hui, Feng Sheng, Dingyi Pan, Chunming Yang, Yi Zheng, Meng-Bo Luo, Ke Yao, and Ben Wang*. Bioinspired shear flow-driven layer-by-layer in situ self-assembly. ACS Nano, 2019, 13(2), 1910–1922. (IF 15.9)
  9. Ben Wang, Peng Liu, Wenge Jiang, Haihua Pan, Xurong Xu and Ruikang Tang*. Yeast cells with an artificial mineral shell: Protection and modification of living cells by biomimetic mineralization. Angewandte Chemie International Edition, 2008, 47 (19), 3560-3564. (IF 15.3)
參考資料
  • 1.    王本  ．浙江大學個人主頁[引用日期2023-10-16]