王曉峯

在西北農業大學園藝系學習，先後獲學士和碩士學位，1993年7月留校任教。1999年在西北農業大學獲博士學位。2000年至2002年在以色列農業研究中心（Volcani Center）和以色列魏茲曼研究所（Weizmann Institute）做博士後研究，2002年至2010年在美國北卡羅來納州州立大學（NC State University）從事科研工作。 ^[1] 

陝西省園藝學會理事，美國高級科學研究學會Sigma XI及美國植物學家學會會員，《FEBS Letters》、《Plant and Cell Physiology》、《Journal of Virological methods》等SCI 期刊的審稿人。 ^[1] 

主要從事植物生化和分子生物學的研究及其在園藝作物代謝調控分子育種上的應用, 內容包括植物組織培養及遺傳轉化，基因克隆和功能分析，植物生長髮育過程中的基因表達調控，植物激素信號傳導的分子機制，植物信號傳導的功能基因組學和蛋白組學等。研究興趣主要為油菜素受體(BRI1) 及其相關受體(BAK1) 的互作組分及信號傳導的分子機理， 膜蛋白受體的生物學功能和相互作用等，並致力於將這些基礎研究的成果應用於園藝作物的栽培和育種實踐。

應用免疫沉澱及液相色譜與質譜連用(LC-MS/MS)，對BRI1(油菜素受體) 和BAK1(油菜素受體相關激酶受體)的活體磷酸化位點進行了系統的鑑定，首次在植物界建立了完整的受體激酶活體磷酸化圖譜。藉助單個位點的定向突變對所鑑定的磷酸化位點的生化和生物學功能進行了評估。通過對BRI1和BAK1複合體形成和磷酸化的研究, 以及對BRI1 和BAK1 的信號分解，揭示了油菜素信號傳導分子機理的幾個重要方面，建立了油菜素早期信號傳導模型。近年來在番茄、白菜和馬鈴薯等蔬菜作物上，通過磷酸化位點突變的基因的過表達和基因敲除編輯，研究油菜素內酯路徑組分的磷酸化位點的農藝學價值及其在分子育種上的應用，以期通過人為操控磷酸化位點的磷酸化，精準調控油菜素內酯信號的強度和特異性，進而改良作物的重要農藝性狀。 ^[1] 

主講課程包括《園藝植物生物技術》、《蔬菜栽培學》、《食用菌栽培學》、《新生研討課》、《科研基本方法》、《瓜果類蔬菜栽培學》、《蔬菜學研究進展》等。 ^[1] 

1) Imkampe J, Halter T, Huang S, Schulze S, Mazzotta S, Schmidt N, Manstretta R, Postel S, Wierzba M, Yang Y2, vanDongen WM, Stahl M, Zipfel C, Goshe MB, Clouse S, de Vries SC, Tax F, Wang X*, Kemmerling B* .(2017) The Arabidopsis Leucine-rich Repeat Receptor Kinase BIR3 Negatively Regulates BAK1 Receptor Complex Formation and Stabilizes BAK1. Plant Cell. Aug 25. pii: tpc.00376.2017. doi: 10.1105/tpc.17.00376. [Epub ahead of print]

2) Shuhua Huang , Shuming Nie , Shufen Wang , Jianwei Liu , Yanfeng Zhang , Xiaofeng Wang*. SlBIR3 (2017) Negatively Regulates PAMP Responses and Cell Death in Tomato. International Journal of Molecular Sciences. 2017 Sep 13;18(9). pii: E1966. doi: 10.3390/ijms18091966.

3) Shuming Nie , Shuhua Huang , Shufen Wang , Dandan Cheng , Jianwei Liu , Siqi Lv , Qi Li , Xiaofeng Wang *. Enhancing Brassinosteroid Signaling via Overexpression of Tomato (Solanum lycopersicum) SlBRI1 Improves Major Agronomic Traits. Front Plant Sci. 2017 Aug 10;8:1386. doi: 10.3389/fpls.2017.01386. eCollection 2017.

4) Cheng Li, Shan Zhang, Xiaofeng Wang*. (2017) Novel Signaling Interface Constituted with Membrane Receptor-Like Kinases Emerged from the Study of Interaction and Transphosphorylation of BRI1 and BAK1. Current Topics in Medicinal Chemistry．17(21):2393-2400. doi: 10.2174/1568026617666170414144145

5) Qiannan Wang, Shufen Wang, Sufu Gan, Xin Wang, Jianwei Liu, Xiaofeng Wang*. (2016) Role of Specific Phosphorylation Sites of Arabidopsis Brassinosteroid-Insensitive 1 Receptor Kinase in Plant Growth and Development. Journal of Plant Growth Regulation. 35(3): 755-769 . DOI 10.1007/s00344-016-9580-7

6) Xin Wang, Dongli Gao, Jinjing Sun, Min Liu, YaoYao Lun, Jianshu Zheng, Shenhao Wang, Qingzhi Cui, Xiaofeng Wang*, Sanwen Huang*. (2016) An exon skipping in a SEPALLATA-Like gene is associated with perturbed floral and fruits development in cucumber. Journal of Integrative Plant Biology. doi: 10.1111/jipb.12472.

7) Shan Zhang, Cheng Li, Qi Li, Qian Nan Wang, Shu Hua Huang, Yan Feng Zhang and Xiao Feng Wang*. (2015) Functional divergence of BAK1 Genes from Brassica rapa in regulating plant architecture. Genetics and Molecular Research. 14 (4): 14587-14596

8) Mitra SK, Chen R, Dhandayham M, Wang xiaofeng, Blackburn RK, Kota U,Goshe MB, Schwarts D, Huber SC, Clouse SD*. (2015) An autophosphorylation site database for leucine-rich repeat receptor-like kinases in Arabidopsis thaliana. Plant Journal:82(6):1042-60.

9) Vikramjit S. Bajwa, Xiaofeng Wang, R. Kevin Blackburn, Michael B. Goshe, Srijeet K. Mitra, Elisabeth L. Williams, Gerard J. Bishop, Sergei Krasnyanski, George Allen, Steven C. Huber, and Steven D. Clouse*. (2013) Identification and Functional Analysis of Tomato BRI1 and BAK1 Receptor Kinase Phosphorylation Sites. Plant Physiology: 163 (1): 30-42.

10) Man-Ho Oh, Xiaofeng Wang, Steven D. Clouse, and Steven C. Huber*.（2012） Deactivation of the Arabidopsis BRI1 receptor kinase by autophosphorylation within the glycine-rich loop involved in ATP binding. Proc Natl Acad Sci U S A, 109(1):327-332.

11) Man-Ho Oh, Xiaofeng Wang, Uma Kota, Michael B. Goshe, Steven D. Clouse, and Steven C. Huber*. (2009) Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of Brassinosteroid signaling in Arabidopsis. Proc Natl Acad Sci U S A, 106 (2):658-663

12) Xiaofeng Wang, Uma Kota, Kai He, Kevin Blackburn, Jia Li, Michael B. Goshe, Steven C. Huber, Steven D. Clouse*. (2008) Sequential transphosphorylation of the BRI1/BAK1 receptor kinase complex impacts early events in Brassinosteroid signaling. Developmental Cell, 15(2):220-235

13) Xiaofeng Wang, Michael B. Goshe, Erik J. Soderblom, Brett S. Phinney, Jason A. Kuchar, Jia Li, Tadao Asami, Shigeo Yoshida, Steven C. Huber, Steven D. Clouse*. (2005) Identification and Functional Analysis of in vivo Phosphorylation Sites of the Arabidopsis BRASSINOSTEROID INSENSITIVE 1 Receptor Kinase. The Plant Cell, 17: 1685-1170

14) Lian-Hai Fu, Xiao-Feng Wang, Yoram Eyal, Gozal Ben-Hayyim*, et al.(2002) A selenoprotein in the plant kingdom: mass spectrometry confirms that an opal codon (UGA) encodes selenocysteine in Chamydomonas reinhadtii glutathion peroxidase. J. Biol. Chem., 277(29):25983-25991 ^[1]