王少林

博士 2004-2009 美國奧本大學農學院分子生物學

本科 1999-2003 中國農業大學生物學院 ^[1] 

2015-至今 中國農業大學動物醫學院 副教授

2010-2014 弗吉尼亞大學醫學院神經遺傳學和藥理基因組學實驗室 研究員

2009-2010 奧本大學水產系魚類分子生物學實驗室 助理研究員 ^[1] 

目前擔任Frontiers in Microbiology和Frontiers in Livestock Genomics等雜誌編委； ^[1] 

目前主要從事藥理基因組, 毒理基因組，微生物相關宏基因組和生物信息學方面的研究； ^[1] 

研究生課程，獸醫基因組學和生物信息學

生物信息學的概念和發展歷史、生物信息學的基礎；分子生物學數據庫，包括生物學數據庫，核苷酸序列與基因組數據庫，蛋白質序列與模式等，及數據庫中存在的問題及使用注意事項；序列比對與數據庫檢索，包括序列比對，比對的統計學顯著性，數據庫搜索；核酸序列的信號和功能識別，包括DNA序列的統計學與信息學分析，核酸和蛋白質序列的進化分析；基因組測序與分析，包括DNA 測序與序列片段的拼接，編碼蛋白質基因區域的預測，基因組的比較；功能基因組信息學，包括功能基因組信息學及基因表達數據分析等。 ^[1] 

發表SCI論文70餘篇，主要研究成果論文引用1500次以上，第一作者及通訊作者文章20餘篇，受邀在國際動植物基因組會議(PAG)上做學術報告4次，參與出版著作3章節。其代表論文有：

Wang X, Wang Y, Wang Y, Zhang S, Shen Z, Wang S*. Emergence of the colistin resistance gene mcr-1 and its variant in several uncommon species of Enterobacteriaceae from commercial poultry farm surrounding environments. Vet Microbiol. 2018 Jun;219:161-164. doi: 10.1016vetmic.2018.04.002. Epub 2018 Apr 14.

Wu C, Wang Y, Shi X, Wang S, Ren H, Shen Z, Wang Y, Lin J, Wang S*. Rapid rise of the ESBL and mcr-1 genes in Escherichia coli of chicken origin in China, 2008-2014. Emerg Microbes Infect. 2018 Mar 14;7(1):30.

Li Y, Sun QL, Shen Y, Zhang Y, Yang JW, Shu LB, Zhou HW, Wang Y, Wang B, Zhang R, Wang S, Shen Z. Rapid Increase in Prevalence of Carbapenem-Resistant Enterobacteriaceae (CRE) and Emergence of Colistin Resistance Gene mcr-1 in CRE in a Hospital in Henan, China. J Clin Microbiol. 2018 Mar 26;56(4). pii:e01932-17.

Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T. Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms. Nat Commun. 2017 Dec 12;8(1):2054.

Wang X, Zhai W, Li J, Liu D, Zhang Q, Shen Z, Wang S*, Wang Y. Presence of mcr-3 variant in Aeromonas caviae, Proteus mirabilis, and Escherichia coli from one domestic duck. Antimicrob Agents Chemother. 2017 Dec 4. pii: AAC.02106-17.

Li J, Shi X, Yin W, Wang Y, Shen Z, Ding S, Wang S*. A Multiplex SYBR Green Real-Time PCR Assay for the Detection of Three Colistin Resistance Genes from Cultured Bacteria, Feces, and Environment Samples. Front Microbiol. 2017 Oct 27;8:2078.

Yin W, Li H, Shen Y, Liu Z, Wang S, Shen Z, Zhang R, Walsh TR, Shen J, Wang Y. Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. MBio. 2017 Jun 27;8(3). pii: e00543-17.

Zhang R, Liu Z, Li J, Lei L, Yin W, Li M, Wu C, Walsh TR, Wang Y, Wang S*, Wu Y. Presence of VIM-Positive Pseudomonas Species in Chickens and Their Surrounding Environment. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00167-17.

Wang Y, Tian GB, Zhang R, Shen Y, Tyrrell JM, Huang X, Zhou H, Lei L, Li HY, Doi Y, Fang Y, Ren H, Zhong LL, Shen Z, Zeng KJ, Wang S, Liu JH, Wu C, Walsh TR, Shen J. Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study. Lancet Infect Dis. 2017 Apr;17(4):390-399.

Wang Y, Zhang R, Li J, Wu Z, Yin W, Schwarz S, Tyrrell JM, Zheng Y, Wang S, Shen Z, Liu Z, Liu J, Lei L, Li M, Zhang Q, Wu C, Zhang Q, Wu Y, Walsh TR, Shen J. Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production. Nat Microbiol. 2017 Feb 6;2:16260.

Yao H, Shen Z, Wang Y, Deng F, Liu D, Naren G, Dai L, Su CC, Wang B, Wang S, Wu C, Yu EW, Zhang Q, Shen J. Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics. MBio. 2016 Sep 20;7(5). pii: e01543-16.

Zhou B, Wang C, Zhao Q, Wang Y, Huo M, Wang J, Wang S* (2016) Prevalence and dissemination of antibiotic resistance genes and coselection of heavy metals in Chinese dairy farms. J Hazard Mater. 2016 Aug 4;320:10-17.

Huo M, Han H, Sun Z, Lu Z, Yao X, Wang S*, Wang J. (2016) Role of IL-17 Pathways in Immune Privilege: A RNA Deep Sequencing Analysis of the Mice Testis Exposure to Fluoride. Sci Rep. 2016 Aug 30;6:32173.

Zhao Q, Wang Y, Wang S, Wang Z, Du XD, Jiang H, Xia X, Shen Z, Ding S, Wu C, Zhou B, Wu Y, Shen J. (2016) Prevalence and Abundance of Florfenicol and Linezolid Resistance Genes in Soils Adjacent to Swine Feedlots. Sci Rep. 2016 Aug 30;6:32192.

Cao J, Nesil T, Wang S, Chang SL, Li MD. (2016) Expression profile of nicotinic acetylcholine receptor subunits in the brain of HIV-1 transgenic rats given chronic nicotine treatment. J Neurovirol. 2016 Oct;22(5):626-633.

Yang J, Wang S, Yang ZL, Hodgkinson CA, Iarikova P, Ma JZ, Payne TJ, Goldman D, Li MD. (2014) The Contribution of Rare and Common Variants in 30 Genes to Risk Nicotine Dependence. Mol Psychiatry. 2015 Nov;20(11):1467-78.

Cui WY, Wang S, Yang J, Yi SG, Yoon D, Kim YJ, Payne TJ, Ma JZ, Park T, Li MD. (2013) Significant association of CHRNB3 variants with nicotine dependence in multiple ethnic populations. Mol Psychiatry. 2013 Nov;18(11):1149-51. (IF=15.147)

Xu P, Zhang X, Wang X, Li J, Liu G, Kuang Y, Xu J, Zheng X, Ren L, Wang G, Zhang Y, Huo L, Zhao Z, Cao D, Lu C, Li C, Zhou Y, Liu Z, Fan Z, Shan G, Li X, Wu S, Song L, Hou G, Jiang Y, Jeney Z, Yu D, Wang L, Shao C, Song L, Sun J, Ji P, Wang J, Li Q, Xu L, Sun F, Feng J, Wang C, Wang S, Wang B, Li Y, Zhu Y, Xue W, Zhao L, Wang J, Gu Y, Lv W, Wu K, Xiao J, Wu J, Zhang Z, Yu J, Sun X. Genome sequence and genetic diversity of the common carp, Cyprinus carpio. Nat Genet.2014 Nov;46(11):1212-9. (IF=29.648)

Wang S, Abernathy J, Waldbieser G, Lindquist E, Richardson, Liu Z and the Catfish Genome Consortium (2010) Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies. Genome Biology 22; 11(1):R8. (IF=10.5)

Lu J, Peatman E, Yang Q, Wang S, Hu Z, Reecy J, Kucuktas H, Liu Z (2011) The catfish genome database cBARBEL: an informatic platform for genome biology of ictalurid catfish. Nucleic Acids Research 2011 Jan;39:D815-21 (IF=8.808)

Wang S, Yang Z, Ma JZ, Payne TJ, Li MD. (2014) Introduction to Deep Sequencing and Its Application to Drug Addiction Research with a Focus on Rare Variants. Mol Neurobiol. 2014 Feb;49(1):601-14. (IF=5.286)

Liu Y, Wang Y, Schwarz S, Wang S, Chen L, Wu C, Shen JZ. (2014) Investigation of a multi-resistance gene cfr that fails to mediate resistance to phenicols and oxazolidinones in Enterococcus faecalis. J Antimicrob Chemother. 2014 Apr; 69(4):892-8. (IF=5.439)

Lu Z, Wang S, Sun Z, Niu R, Wang J. (2014) In vivo influence of sodium fluoride onsperm chemotaxis in male mice. Arch Toxicol. 2014 Feb;88(2):533-9. (IF=5.078)

Wang S, van der Vaart A, Seneviratne C, Xu Q, Pomerleau OF, Pomerleau CS, Payne TJ, Ma JZ, Li MD. (2014) Significant Associations of CHRNA2 and CHRNA6 with Nicotine Dependence in European-American and African-American Populations. Human Genetics. 2014 May;133(5):575-86. (IF=4.633)

Luo GY, Wang S, Li ZG, Wang JD. (2014) Maternal BisphenolA Diet Induces Anxiety-like Behavior in Female Adolescents with Neuroimmune Activation. Toxical Science, in press (IF=4.478)

Wang S, Liu H, Wang Y, Kucuktas H, Bushek D, Wang L, Shi Y, Quilang J, Li P, Wallace R, Guo X, Liu Z (2010) Microarray analysis of gene expression in eastern Oyster (Crassostrea virginica) reveals oxidative stress and apoptosis host responses after dermo (Perkinsus marinus) challenge. Fish & Shellfish Immunology 2010 Dec;29(6):921-9 (IF=3.034)

Cao J, Wang S, Wang J, Cui W, Nesil T, Vigorito M, Chang SL, Li MD. (2013) RNA Deep Sequencing Analysis Reveals that Nicotine Restores Impaired Gene Expression by Viral Proteins in the Brains of HIV-1 Transgenic Rats. PloS One 2013 Jul 16;8(7):e68517. (IF=3.534，)

Li MD, Cao J, Wang S, Wang J, Sarkar S, Vigorito M, and Chang SL (2013) Transcriptome sequencing analysis of gene expression in the brains of HIV-1 transgenic rats. Plos One 2013;8(3):e59582 (IF=3.534)

Li EC, Wang S, Li C, Wang XD, Chen K, Chen LQ. (2014) Transcriptome Sequencing Revealed the Genes and Pathways Involved in Salinity Stress of Chinese Mitten Crab, Eriocheir sinensis. Physiological Genome 2014 Mar 1; 46(5):177-90. (IF=2.812) ^[1] 

主持國家重點研發計劃課題1項，共主持參與項自然科學基金5項，2018年獲得北京市科技新星。其代表項目有：

2016-2019 科技部：國家重點研發計劃-畜禽重要病原耐藥性檢測與控制技術研究，畜禽病原菌耐藥性檢測技術研究（批准號：2016YFD0501301，520萬）主持

2016-2019 中國國家自然科學基金：通過宏基因組研究豬場養殖環境中的β-內酰胺酶基因流行和傳播機制 （批准號：NSF31572568，76萬）主持

2016-2019 中國國家自然科學基金：雞源碳青黴烯類抗生素耐藥大腸桿菌的產生機制和適應性研究 （批准號：NSF31530076，328萬）參與

中國國家自然科學基金：泛耐藥腸桿菌細菌在動物、食品/環境、人之間的傳播及其影響研究 （批准號：NSF81661138002，252萬）參與 ^[1]