王小明

中國化學會會員

中國藥學會高級會員

天然藥物化學

化學生物學 ^[1] 

1.Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Jin-Liang Qi, Rong-Wu Yang, Wang Xiao-Ming * and Yang Yong-Hua. Synthesis of phenyl thiazole acyl shikonin ester derivatives as anti-cancer agents through microtubule stabilization. Biochemical Pharmacology. 2015, 96(2), 93-106.

2.Qiu Han-Yue, Wang Peng-Fei, Li Zhen, Ma Jun-Ting, Wang Xiao-Ming, * Yang Yong-Hua, Zhu Hai-Liang. Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. Pharmacological Research. 2016, 104: 86-96.

3.Qiu Han-Yue, Zhu Xiang, Luo Yue-Lin, Lin Hong-Yan, Tang Cheng-Yi, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Shikonin Derivatives Targeting STAT3 SH2 Domain Induce Antitumor Effects. Scientific Reports 2017, 7, 2863.

4.Hu Yang, Li Cui-Yun, Wang Xiao-Ming, Yang Yong-Hua, Zhu Hai-Liang. 1, 3, 4-Thiadiazole: synthesis, reactions and applications in medicinal, agricultural, materials chemistry. Chemical Reviews. 2014, 114(10): 5572-5610.

5.Sun Wen-Xue, Ji Ya-Jing, Wan Yun, Han Hong-Wei, Lin Hong-Yan, Lu Gui-Hua, Qi Jin-Liang*, Wang Xiao-Ming*, Yang Yong-Hua*. Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents. Bioorganic & Medicinal Chemistry Letters 2017, 27 4066–4074.

6.Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of a synthesized Shikonin ester against influenza A (H1N1)virus and its insights into its mechanism. Biomedicine & Pharmacotherapy 2017,93:636-645.

7.Zhang Ya-Han, Han Hong-Wei, Qiu Han-Yue, Lin Hong-Yan, Yu Lu-Gang, Zhu Wan-Zhan, Qi Jin-Liang, Yang Rong-Wu, Pang Yan-Jun, Wang Xiao-Ming, * Lu Gui-Hua, and Yang Yong-Hua. Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro. Brazilian Journal of Medical and Biological Research 2017,50(10): e6586.

8.Qiu Han-Yue, Wang Fang, Wang Xue, Sun Wen-Xue, Qi Jin-Liang, Pang Yan-Jun, Yang Rong-Wu, Lu Gui-Hua, Wang Xiao-Ming,* Yang Yong-Hua. Design, synthesis, and biological evaluation of chalcone-containing shikonin derivatives as inhibitors of tubulin polymerization.ChemMedChem 2017,12(5):399-406.

9.Wang Zi-Zhen, Sun Wen-Xue, Wang Xue, Zhang Ya-Han, Qiu Han-Yue, Qi Jin-Liang, Pang Yan-Jun, Lu Gui-Hua, Wang Xiao-Ming,* Yu Fu-Gen, Yang Yong-Hua. Design, Synthesis, Biological evaluation and 3D-QSAR Analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents. Chemical Biology & Drug Design 2017，90:236-243.

10.Qiu Han-Yue, Wang Peng-Fei, Wang Zi-Zhen, Luo Yue-Lin, Hu Dong-Qing, Qi Jin-Liang, Lu Gui-Hua, Pang Yan-Jun, Yang Rong-Wu, Zhu Hai-Liang, Wang Xiao-Ming*, Yang Yong-Hua*. Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and biological evaluation. RSC Advances, 2016, 6, 83003-83010.

11.Han Hong-Wei, Qiu Han-Yue, Hu Cui, Sun Wen-Xue, Yang Rong-Wu, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua and Yang Yong-Hua. Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs. Bioorganic & Medicinal Chemistry Letters 2016,26(14),3237-3242.

12.Baloch Karim Shahla, Ma Lin, Wang Xue-Liang, Shi Jing, Zhu Yu, Wu Feng-Yao, Pang Yan-Jun, Lu Gui-Hua, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-We and Yang Yong-Hua. Design, Synthesis and Mechanism of Novel Shikonin Derivatives as Potent Anticancer Agents. RSC Advances, 2015, 5(40), 31759-31767.

13.Lin Hong-Yan, Li Zi-Kang, Han Hong-Wei, Qiu Han-Yue, Gu Hong-Wei, Yang Yong-Hua, Wang Xiao-Ming.* Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential anti-tubulin agents RSC Advances, 2015, 5(59),47511-47521.

14.Lin Hong-Yan, Bai Li-Fei, Wang Fang, Wu Xun, Han Lu-Jing, Baloch Karim Shahla, Yang Yong-Hua, Wang Xiao-Ming.* Semi-synthesis and anti-lung cancer activity evaluation of aryl thiazol acyl podophyllotoxin ester derivatives. RSC Advances 2015, 5(35), 27775 - 27784.

15.Baloch Karim Shahla, Ma Lin, Xu Guo-Hua, Bai Li-Fei, Zhao Hua, Tang Cheng-Yi, Pang Yan-Jun, Yang Rong-Wu, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. A Potent Anticancer Agent of Shikonin Derivative Targeting Tubulin, Chirality 2015, 27：274-280.

16.Lin Hong-Yan, Han Hong-Wei, Bai Li-Fei, Qiu Han-Yue, Yin De-Zheng, Qi Jin-Liang, Wang Xiao-Ming,* Gu Hong-Wei and Yang Yong-Hua. Design, Synthesis and Biological Evaluation of Shikonin Thio-glycoside Derivatives: New Anti-Tubulin Agents. RSC Advances 2014,4(91)，49796-49805.

17.Qiu Han-Yue, Wang Zhong-Chang, Wang Peng-Fei, Yan Xiao-Qiang, Wang Xiao-Ming*, Yang Yong-Hua, Zhu Hai-Liang. Design, Synthesis, Evaluation and 3D-QSAR Analysis of Benzosulfonamide Benzenesulfonates as Potent and Selective Inhibitors of MMP-2. RSC Advances 2014, 4(74), 39214−39225.

18.Baloch Karim Shahla, Ling Li-Jun, Qiu Han-Yue, Ma Lin, Lin Hong-Yan, Huang Shou-Cheng, Qi Jin-Liang, Wang Xiao-Ming,* Lu Gui-Hua, Yang Yong-Hua. Synthesis and biological evaluation of novel shikonin ester derivatives as potential anti-cancer agents. RSC Advances 2014, 4(67), 35588−35596.

19.Guo Jing, Chen Xiao-Feng, Liu Jing, Lin Hong-Yan, Han Hong-Wei, Liu Hong-Chang, Huang Shou-Cheng, Baloch Karim Shahla, Andrew Kulek, Qi Jin-Liang,Wang Xiao-Ming, * Ling Li-Jun,* and Yang Yong-Hua. Novel Shikonin Derivatives Targeting Tubulin as Anti-cancer Agents. Chemical Biology & Drug Design 2014, 84(5), 603−615.

20.Wang Xiao-Ming, Lin Hong-Yan, Kong Wen-Yao, Guo Jing, Shi Jing, Huang Shou-Cheng, Qi Jin-Liang, Yang Rong-Wu, Gu Hong-Wei and Yang Yong-Hua.* Synthesis and Biological Evaluation of Heterocyclic Carboxylic Acyl Shikonin Derivatives. Chemical Biology & Drug Design 2014, 83(3):331-343.

21.Dong Jing-Jun, Li Qing-Shan, Liu Zhi-Peng, Wang Shu-Fu, Zhao Meng-Yue, Yang Yong-Hua, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, Biological Evaluation and Molecular Docking Studies of Flavone and Isoflavone Derivatives as a Novel Class of KSP (Kinesin Spindle Protein) Inhibitors. European Journal of Medicinal Chemistry 2013, 70, 427-433.

22.Kong Wen-Yao, Chen Xiao-Feng, Shi Jing, Baloch Karim Shahla, Qi Jin-Liang, Zhu Hai-Liang, Wang Xiao-Ming* and Yang Yong-Hua. Design and Synthesis of Fluoroacylshikonin as Anticancer Agents. Chirality 2013, 25, 757-762.

23.Zhang Hao, Zheng Yu-Qiong, Guo Jing, Wang Xiao-Ming*, and Yang Yong-Hu. Synthesis, Docking and Biological Evaluations of Isoquinolonic Acid Derivatives. Chemical Research in Chinese Universities. 2013, 29(6): 1110-1114.

24.Li Yao, Zhao Chang-Po, Ma Hua-Ping, Zhao Meng-Yue, Xue Ya-Rong, Wang Xiao-Ming*, Zhu Hai-Liang. Design, Synthesis and Antimicrobial Activities Evaluation of Schiff Base Derived from Secnidazole Derivatives as Potential FabH Inhibitors. Bioorganic & Medicinal Chemistry. 2013, 21(11): 3120-3126.

25.Sun Juan, Li Ming-Hui, Qian Shao-Song, Guo Feng-Jiao, Dang Xiao-Fang, Wang Xiao-Ming*, Xue Ya-Rong, Zhu Hai-Liang. Synthesis and Antitumor Activity of 1, 3, 4-oxadiazole Possessing 1, 4-benzodioxan Moiety as a Novel Class of Potent Methionine Aminopeptidase type II Inhibitors. Bioorganic & Medicinal Chemistry Letters. 2013, 23(10): 2876-2879.

26.Lin Hong-Yan, Chen Wei, Shi Jing, Kong Wen-Yao, Qi Jin-Liang, Wang Xiao-Ming * and Yang Yong-Hua. Design, synthesis and biological evaluation of cinnamic acyl shikonin derivatives. Chemical Biology & Drug Design. 2013, 81(2), 275-283.

27.Luo Yin, Zhang Li-Rong, Hu Yang, Zhang Shuai, Fu Jie, Wang Xiao-Ming*, and Zhu Hai-Liang. Synthesis and Antimicrobial Activities of Oximes Derived from O-Benzyl hydroxylamine as FabH Inhibitors. ChemMedChem. 2012, 7(9), 1587-1593.

28.Yang Xian-Hui, Lu Xiang, Li Xi, Zhao Ting-Ting, Zhang Hui, Zhou Wen-Ping, Wang Xiao- Ming*, Gong Hai-Bin, Zhu Hai-Liang. Synthesis, biological evaluation, and molecular docking studies of 1, 3, 4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorganic & Medicinal Chemistry. 2012, 20(9): 2789-2795.

29.Qiu Ke-Ming, Wang Hai-Hong, Wang Li-Ming, Luo Yin, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of pyrazolyl-thiazolinone derivatives as potential EGFR and HER-2 kinase inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(6): 2010-2018.

30.Zhang Hui, Lu Xiang, Zhang Li-Rong, Liu Jia-Jia, Yang Xian-Hui, Wang Xiao-Ming*, Zhu Hai-Liang. Design, synthesis and biological evaluation of N-phenylsulfonylnicotinamide derivatives as novel antitumor inhibitors. Bioorganic & Medicinal Chemistry. 2012, 20(4): 1411-1416.

31. Zhang Hong-Jia, Qin Xuan, Liu Kai, Zhu Di-Di, Wang Xiao-Ming*, Zhu Hai-Liang. Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N0-phenyl-thiourea. Bioorganic & Medicinal Chemistry. 2011, 19(18): 5708-5715.

32.Sun Juan, Cao Ning, Zhang Xiao-Min, Yang Yu-Shun, Zhang Yan-Bin, Wang Xiao-Ming*, Zhu Hai-Liang. Oxadiazole derivatives containing 1, 4-benzodioxan as potential Immuno -suppressive agents against RAW264.7 cells. Bioorganic & Medicinal Chemistry. 2011, 19(16): 4895-4902.

33.Wang Xiao-Ming, Zhang Suo-Qin, Zhu Ling, Wang Si-Si, Li Xin-Yuan, Fang Qian-Rong, Yin Ya-Le, Liu Hao-Yan, Li Yao-Xian, Jia Gao-Feng, Pang Yan-Jun, Qi Jin-Liang, Wang Xiu-Qiang, Yang Yong-Hua*. Synthesis and Crystal Structure of N3-(dimethylpyrimidine) -N4-(tri-O-acetyl-xylosyl) thiourea. Chinese Journal of Structural Chemistry. 2008. 27(3): 321-325.

34.Wang Xiao-Ming, Li Yao-Xian, Liu Hao Yan, Li Xin-Yuan, Yang Yong-Hua, Jia Gao-Feng, Zhang Suo-Qin*. “Synthesis and Characterization of Novel N-glucoside”. Acta Chimica Sinica. 2008, 66(4): 492-495.

35.Wang Xiao-Ming, Zhu Tao, Zheng Liang-Yu, Li Yao-Xian, Zhang Suo-Qin, Bai Jie. “Synthesis of β-D-Glucopyranosyl Thiourea and Biological Activity”. Chinese Journal of Organic Chemistry. 2006, 26(5): 660-666.

36.Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Yang Song-Tao, Wang Xiao-Ming, Wang Yong- Zhi, Bai Jie, Liu Fu-An. New N-terminal prolyl-dipeptide derivatives as organocatalysts for direct asymmetric aldol reaction. Tetrahedron Letters. 2006, 47: 7793-7796.

37.Zheng Ji-Fu, Li Yao-Xian, Zhang Suo-Qin, Wang Xiao-Ming, Yang Song-Tao, Bai Jie, Wang Fang, Zhang Guang-Liang, Liu Fu-An. Studies on Synthesis of Novel Chiral Organocatalysts and Its Evaluations for Asymmetric Direct Aldol Reactions. Acta Chimica Sinica. 2007, 65(6): 553-556.

38.Yang Song-Tao, Zhang Suo-Qin, Zhang Guang-Liang, Wang Xiao-Ming and Li Yao-Xian. Novel Catalytic Method for Synthesis of Glycosyl Esters by Combining PTC with DMAP. Chemical Research in Chinese Universities 2007, 23(4): 426-429.

二、王小明已經發表的會議文章列表：

1.Lin Hong-Yan, Li Zi-Kang, Bai Li-Fei, Baloch Karim Shahla, Wang Fang, Qiu Han-Yue, Wang Xue, Qi Jin-Liang, Yang Rong-Wu, Wang Xiao-Ming*, Yang Yong-Hua *. Synthesis of Phenyl Thiazole Acyl Shikonin Ester Derivatives as Anti-cancer Agents through Microtubule Stabilization. Drug Discovery & Therapy World Congress 2015, Boston, USA (2015. 7.22-26)

2.Han Hong-Wei, Qiu Han-Yue, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and Biological Evaluation of Podophyllotoxin Derivatives as Potent Anticancer Agents.2015第九屆有機化學會議，長春，東北師範大學(2015)(邀請報告)

3.Han Hong-Wei, Han Lu-jing, Wang Xiao-Ming*, Yang Yong-Hua*. A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年長三角藥物化學會議，南京，中醫藥大學藥學院(2015.11.13-14)

4.Li Deng-Chao, Shi Jing, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年長三角藥物化學會議，南京，中醫藥大學藥學院(2015.11.13-14)

5.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming*, Yang Yong-Hua*. Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年長三角藥物化學會議，南京，中醫藥大學藥學院(2015.11.13-14)(口頭報告)

6.Han Hong-Wei, Han Lu-Jing, Wang Xiao-Ming,* and Yang Yong-Hua.* A novel shikonin derivative induces the cervical cancer cell line Hela cells via mitochondria-mediated pathway. 2015年長三角藥物化學會議，牆報，南京，中醫藥大學藥學院(2015.11.13-14)

7.Li Deng-Chao, Shi Jing, Wang Xiao-Ming,* and Yang Yong-Hua. * Synthesize and anticancer mechanism of a novel shikonin derivative as an EGFR Inhibitor. 2015年長三角藥物化學會議，牆報，南京，中醫藥大學藥學院(2015.11.13-14)

8.Qiu Han-Yue, Wang Zi-Zhen, Luo Yue-Lin, Wang Xiao-Ming,* Yang Yong-Hua.* Synthesis and evaluation of novel shikonin derivatives as potent antitumor agents. 2015年長三角藥物化學會議，牆報，南京，中醫藥大學藥學院(2015.11.13-14)

9.王小明,* 孔文堯, 鄭雨瓊, 楊永華.* 2011. 異喹啉酸衍生物的合成，中國化學會第七屆有機化學學術會議論文集, No.3-8, P1195. 南京，2011.11.12-15

10.浩日沁巴圖, 林紅燕, 王小明,* 楊永華.* 新法合成2, 3-二氨基吡啶，中國化學會第七屆有機化學學術會議論文集, No.3-3, P1190. 南京，2011.11.12-15

11.Liu Hong-Chang, Shi Jing, Wang Xiao-Ming,* Yang Yong-Hua.* synthesis of Novel 5, 8- Dihydroxy-1, 4-Naphthoquinone Derivatives, 中國化學會第七屆有機化學學術會議論文集, No.3-4, P1191. 南京，2011.11.12-15

12.王小明, 劉昊琰，張靖靖，楊永華. * 鄰苯二甲酰肼取代二硝基苯胺的合成，2009年，中國化學會第六屆有機化學學術會議論文集; P545. 西安，2009.8.17-20

13.王小明, 李鑫源，袁文，賀斐，楊永華. * 2007 “新型Topo I異構酶抑制劑的設計與合成”.年. 中國化學會第五屆有機化學學術會議論文集，P374, 鄭州，2007. 8. 1-4.

14.王小明, 龐延軍，劉少華，楊永華，張鎖秦，李耀先. 2006. “基於生物安全新型糖酯除草化合物的設計合成” 中國農業生物技術學會生物安全分會成立會論文集，P44, 南京，2006.12.1-3. ^[1] 

石明旺主編，王小明第一副主編. 新編常用農藥安全使用指南. 北京：化學工業出版社(2010.12) ^[1] 

1.王小明，繆律，張浩，楊永華，浩日沁巴圖，劉昊琰，楊曉亮，石明旺，田壯，鄭雨瓊，乙酰化糖基硫脲衍生物製備及其在異喹啉酸合成中的應用，授權號：ZL201010180446.9

2.王小明，楊永華，劉洪昌，石婧，孔文堯，郭靖，黃守程，劉靜，孔令如，張培培. 紫草寧苯氧羧酸酯類衍生物及其合成方法和應用.授權號：ZL201210122226.X，

3.王小明，劉業好，劉根林，楊永華，劉昊琰，顧宏偉，王玲玲，朱思梅，陳靜，萘茜糖類衍生物及其製備方法和應用，公開號：CN 101824058A

4.王小明，楊永華，邱寒月，陸桂華，林紅燕，韓洪葦. 紫草寧衍生物及其合成方法和應用，申請號：201410249794.5

5.王小明，楊永華，邱寒月，林紅燕，韓洪葦. 一種羥肟酸類化合物及其製備方法與應用， 公開號：CN104140382A

6.王小明，楊永華，石婧. 一類新穎結構紫草寧酯作為表皮生長因子受體抑制劑的應用，申請號：20130478312.9

7.楊永華, 王小明, 劉少華, 李鑫源, 劉昊琰, 趙衞國, 楊建文, 殷晶晶, 袁文勇, 聖丙剛. 紫草寧糖類衍生物及其合成方法和應用.授權號：ZL200810195039.8

8.楊永華, 王小明, 浩日沁巴圖, 劉洪昌, 戚金亮, 林紅燕, 石婧, 孔文堯. 紫草寧含氟羧酸酯類衍生物及其合成方法和應用，公開號：CN102491897A

9.楊永華，王小明，浩日沁巴圖，韓秋敏，劉洪昌，林紅燕，石婧，孔文堯. 二取代和三取代糖基紫草寧衍生物及其製備方法和應用，公開號：CN102516330A

10.楊永華，王小明，林紅燕，石婧，劉洪昌，孔文堯，浩日沁巴圖，黃守程，紫草寧肉桂酸酯類衍生物及其合成方法和應用，公開號：CN102531893A

11.楊永華，孔文堯，石婧，王小明，張培培，劉洪昌，林紅燕，孔令如，劉靜，郭靖. 一類紫草寧酯類衍生物的合成方法及應用，公開號：CN102659661A

12.楊永華，夏紅梅，戚金亮，王小明，楊榮武，劉洪昌，浩日沁巴圖，張靖靖，孔文 堯.紫草寧及其衍生物或修飾物的脂質體的製備方法和應用， 公開號：CN102091037A ^[1]