沈前華

2008-至今, 中國科學院遺傳與發育生物學研究所，研究員，入選中國科學院“BR計劃”海外引進人才

2004-2008 德國馬普植物育種研究所(Max Planck Institute for Plant Breeding Research)，博士後

2001-2004 德國馬普植物育種研究所和科隆大學(University of Cologne)，獲博士學位

1999-2000 英國John Innes Centre和東安格利亞大學(University of East Anglia)，獲碩士學位

1998-1999 英國西敏寺大學(University of Westminster)，國家留學基金委派出訪問學者

1987-1998 於江西大學、南昌大學工作，歷任助教、講師、副教授

1985-1987 華中農業大學植物遺傳育種專業，研究生

1981-1985 江西農業大學，獲學士學位

植物-病原菌分子互作，植物免疫機制

擔任中國植物病理學會理事會常務理事；植物生理與分子生物學學會植物與微生物互作專業委員會副主任；

Phytopathology Research, Associate Editor；Frontiers of Agricultural Science and Engineering, Associate Editor; Frontier in Plant Science, Associate Editor。

植物如何識別病原菌並激活抗病，病原菌如何巧妙地躲避識別或抑制寄主抗性，專性寄生真菌如何與植物建立寄生關係等等是重要的生物學前沿問題。作物抗病性也是重要的穩產性狀，提高作物品種的抗病性可以減少農藥使用、保護環境、綠色生產。實驗室採用重要糧食作物大小麥與白粉菌分子互作的研究體系，採用遺傳學、細胞生物學、生物化學和組學等研究手段研究作物抗病的分子機制，研究重要病原真菌的致病分子機理, 挖掘新型抗病基因，為抗病育種提供理論基礎，並應用於創制抗病育種材料。

研究抗病蛋白的抗病機制，探索抗病基因在抗病育種中的應用。抗病蛋白或NLR免疫受體介導對病原菌專化性識別並誘導抗病免疫反應，我們研究這類抗病蛋白誘導抗病及細胞死亡的分子機制，以及抗病激活與轉錄重編程的關係，鑑定抗病蛋白複合體組份及下游信號組份，闡明抗病基因轉錄及翻譯後的調控機制。

病原真菌（如白粉菌）編碼數百個效應蛋白，大多被分泌到寄主細胞中，通過干擾寄主的靶標蛋白功能抑制植物的抗病免疫反應增強病原菌致病性。植物和病原真菌的小分子RNA（主要是miRNA、siRNA）在植物與病原菌互作中也發揮重要的調控作用，並通過跨界調控靶標基因的表達起調控作用。通過研究效應蛋白的功能和作用機制，鑑定sRNA以及靶標基因及其調控機制，闡明跨界sRNA的作用機制。

麥類作物真菌病害主要包括白粉病、鏽病和赤黴病。我們研究大、小麥對病原真菌的抗病遺傳，篩選抗病種質資源、挖掘抗病新位點，通過GWAS等技術鑑定和克隆新型抗病基因，包括廣譜和專化性抗病基因。

（#第一作者，*通訊作者） ^[1] 

1.Huaibing Jin#, Xinyun Han#, Zhaohui Wang#, Yilin Xie, Kunpu Zhang, Xiaoge Zhao, Lina Wang, Jin Yang, Huiyun Liu, Xiang Ji, Lingli Dong, Hongyuan Zheng, Weijuan Hu, Yan Liu, Xifeng Wang, Xueping Zhou, Yijing Zhang, Weiqiang Qian, Wenming Zheng, Qian-Hua Shen*, Mingyue Gou* and Daowen Wang*. Barley GRIK1-SnRK1 kinases subvert a viral virulence protein to upregulate antiviral RNAi and inhibit infection. EMBO journal, e110521. (2022)

2.Deshui Yu, Renchun Fan, Ling Zhang, Pengya Xue, Libing Liao, Meizhen Hu, Yanjun Cheng, Jine Li, Ting Qi, Shaojuan Jing, Qiuyun Wang, Arvind Bhatt and Qian-Hua Shen*. HvWRKY2 acts as an immunity suppressor and targets HvCEBiP to regulate powdery mildew resistance in barley. Crop Journal, doi: 10.1016/j.cj.2022.05.010. (2022)

3.Xinmeng Gui, Peng Zhang, Dan Wang, Zhan Ding, Xian Wu, Jinxia Shi, Qian-Hua Shen, Yong-Zhen Xu, Wenbo Ma and Yongli Qiao. Phytophthora effector PSR1 hijacks the host pre-mRNA splicing machinery to modulate small RNA biogenesis and plant immunity. Plant Cell, 34: 3443-3459. (2022)

4.Baoyu Huai#, Pu Yuan#, Xiaoxuan Ma, Xiurui Zhang, Lihua Jiang, Peijing Zheng, Mohan Yao, Ziyu Chen, Liyang Chen, Qian-Hua Shen, Zhensheng Kang* and Jie Liu*. Sugar transporter TaSTP3 activation by TaWRKY19/61/82 enhances stripe rust susceptibility in wheat. New Phytologist, 236: 266-282. (2022)

5.Qiang Zhang#, Yinghui Li#, Yiwen Li, Tzion Fahima, Qian-Hua Shen* and Chaojie Xie*. Introgression of the Powdery Mildew Resistance Genes Pm60 and Pm60b from Triticum urartu to Common Wheat Using Durum as a ‘Bridge’. Pathogens, 11(1), 25. (2021)

6.Hongbo Yuan, Cong Jin, Hongcui Pei, Lifang Zhao, Xue Li, Jiali Li, Wanting Huang, Renchun Fan, Wende Liu and Qian-Hua Shen*. The Powdery Mildew Effector CSEP0027 Interacts with Barley Catalase to Regulate Host Immunity. Frontiers in Plant Science, doi: 10.3389/fpls.2021.733237. (2021)

7.Xue Li#, Cong Jin#, Hongbo Yuan#, Wanting Huang, Fang Liu, Renchun Fan, Jiankun Xie* and Qian-Hua Shen*. The barley powdery mildew effectors CSEP0139 and CSEP0182 suppress cell death and promote B. graminis fungal virulence in plants. Phytopathology Research, doi:10.1186/s42483-021-00084-z. (2021)

8.Xinyun Han#, Ling Zhang#, Lifang Zhao#, Pengya Xue, Ting Qi, Chunlei Zhang, Hongbo Yuan, Lixun Zhou, Daowen Wang, Jinlong Qiu and Qian-Hua Shen*. SnRK1 Phosphorylates and Destabilizes WRKY3 to Enhance Barley Immunity to Powdery Mildew. Plant Communications, 1(4):100083. (2020)

9.Fukai Zhao#, Yinghui Li#, Baoju Yang, Hongbo Yuan, Cong Jin, Lixun Zhou, Hongcui Pei, Lifang Zhao, Yiwen Li, Yilin Zhou, Jiankun Xie* and Qian-Hua Shen*. Powdery mildew disease resistance and marker-assisted screening at the Pm60 locus in wild diploid wheat Triticum urartu. Crop Journal, 8:252-259. (2020)

10. Huaibing Jin#, Zhiqiang Du#, Yanjing Zhang#, Judit Antal#, Zongliang Xia, Yan Wang, Yang Gao, Xiaoge Zhao, Xinyun Han, Yanjun Cheng, Qian-Hua Shen, Kunpu Zhang, Robert E. Elder, Zsigmond Benko, Csaba Fenyvuesvolgyi, Ge Li, Dionne Rebello, Jing Li, Shilai Bao, Richard Y. Zhao* and Daowen Wang*. A distinct class of plant and animal viral proteins that disrupt mitosis by directly interrupting the mitotic entry switch Wee1-Cdc25-Cdk1. Science Advances, 6(20):eaba3418. (2020)

11. Tao Wang, Jiaxin Li and Qian-Hua Shen*. Regulation of NLR stability in plant immunity. Frontiers of Agricultural Science and Engineering, 6:97. (2019)

12. Jingjing Xing#, Xiaojuan Li#, Xiaohua Wang, Xueqin Lv, Li Wang, Liang Zhang, Yingfang Zhu, Qian-Hua Shen, Franti？ek Balu？ka, Jozef ？amaj and Jinxing Lin*. Secretion of Phospholipase Dδ Functions as a Regulatory Mechanism in Plant Innate Immunity. Plant Cell, 31(12):3015-3032. (2019)

13. Hongyuan Zheng#, Lingli Dong#, Xinyun Han, Huaibing Jin, Cuicui Yin, Yali Han, Bei Li, Huanju Qin, Jinsong Zhang, Qian-Hua Shen, Kunpu Zhang* and Daowen Wang*. The TuMYB46L-TuACO3 module regulates ethylene biosynthesis in einkorn wheat defense to powdery mildew. New Phytologist, 225:2526-2541. (2019)

14. Min Zhu#, Lei Jiang#, Baohui Bai, Wenyang Zhao, Xiaojiao Chen, Jia Li, Yong Liu, Zhengqiang Chen, Boting Wang, Chunli Wang, Qian Wu, Qian-Hua Shen, Savithramma P. Dinesh-Kumar, and Xiaorong Tao*. The Intracellular Immune Receptor Sw-5b Confers Broad-Spectrum Resistance to Tospoviruses through Recognition of a Conserved 21-Amino Acid Viral Effector Epitope. Plant Cell, 29(9):2214-2232. (2017)

15. Tao Wang, Cheng Chang, Cheng Gu, Sanyuan Tang, Qi Xie, and Qian-Hua Shen*. An E3 ligase affects the NLR receptor stability and immunity to powdery mildew. Plant Physiology, 172(4):2504-2515. (2016)

16. Yanfei Zhu, Yingbo Li, Fei Fei, Zongkuan Wang, Wei Wang, Aizhong Cao, Yuan Liu, Shuang Han, Liping Xing, Haiyan Wang, Wei Chen, Sanyuan Tang, Xiahe Huang, Qian-Hua Shen, Qi Xie, Xiue Wang*. E3 ubiquitin ligase gene CMPG1–V from Haynaldia villosa L. contributes to powdery mildew resistance in common wheat (Triticum aestivum L.). Plant Journal, 84(1):154-168. (2015)

17. Jie Liu, Xiliu Cheng, Da Liu, Weihui Xu, Roger Wise and Qian-Hua Shen*. The miR9863 Family Regulates Distinct Mla Alleles in Barley to Attenuate NLR Receptor-Triggered Disease Resistance and Cell-Death Signaling. PLoS Genetics, 10(12):e1004755. (2014)

18. Meng Li, Xiqing Ma, Yi-Hsuan Chiang, Koste A. Yadeta, Pengfei Ding, Liansai Dong, Yan Zhao, Xiuming Li, Yufei Yu, Ling Zhang, Qian-Hua Shen, Bin Xia, Gitta Coaker, Dong Liu*, and Jian-Min Zhou*. Proline Isomerization of the Immune Receptor-Interacting Protein RIN4 by a Cyclophilin Inhibits Effector-Triggered Immunity in Arabidopsis. Cell Host & Microbe, 16(4):473-483. (2014)

19. Cheng Chang, Deshui Yu, Jian Jiao, Shaojuan Jing, Paul Schulze-Lefert, and Qian-Hua Shen*. Barley MLA Immune Receptors Directly Interfere with Antagonistically Acting Transcription Factors to Initiate Disease Resistance Signaling. Plant Cell, 25:1158-1173. (2013)

20. Cheng Chang, Ling Zhang and Qian-Hua Shen*. Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling. Frontiers in Plant Science, doi:10.3389/fpls.2013.00396. (2013)

21. Hong-Qing Ling#, Shancen Zhao#, Dongcheng Liu#, Junyi Wang#, Hua Sun#, Chi Zhang#, ..., Qian-Hua Shen, ..., Huanming Yang, Zhensheng Li, Daowen Wang, Aimin Zhang and Jun Wang. Draft genome of the wheat A-genome progenitor Triticum urartu. Nature, 496: 87-90. (2013)

22. Yumei Du#, Jinping Zhao#, Tianyuan Chen#, Qi Liu1, Haili Zhang, Yan Wang, Yiguo Hong, Fangming Xiao, Ling Zhang, Qian-Hua Shen and Yule Liu*. Type I J-Domain NbMIP1 Proteins Are Required for Both Tobacco Mosaic Virus Infection and Plant Innate Immunity. PLoS Pathogens, 9: e1003659. (2013)

23. Shiwei Bai, Jie Liu, Cheng Chang, Ling Zhang, Takaki Maekawa, Qiuyun Wang, Wenkai Xiao, Yule Liu, Jijie Chai, Frank L. W. Takken, Paul Schulze-Lefert and Qian-Hua Shen*. Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance. PLoS Pathogens, 8: e1002752. (2012)

24. Takaki Maekawa, Wei Cheng, Laurentiu N. Spiridon, Armin T？ller, Ewa Lukasik, Yusuke Saijo, Peiyuan Liu, Qian-Hua Shen, Marius A. Micluta, Imre E. Somssich, Frank L.W. Takken, Andrei-Jose Petrescu, Jijie Chai*, and Paul Schulze-Lefert*. Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death. Cell Host & Microbe, 9:187-199. (2011)

25. Guan-Feng Wang#, Xuening Wei#, Renchun Fan, Huanbin Zhou, Xianping Wang, Chunmei Yu, Lingli Dong, Zhenying Dong, Xiaojie Wang, Zhensheng Kang, Hongqing Ling, Qian-Hua Shen, Daowen Wang and Xiangqi Zhang*. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytologist, 191: 418-431. (2011)

26. Chunmei Yu, Yiwen Li, Bin Li, Xin Liu, Lifang Hao, Jing Chen, Weiqiang Qian, Shiming Li, Guanfeng Wang, Shiwei Bai, Hua Ye, Huanju Qin, Qian-Hua Shen, Liangbiao Chen, Aimin Zhang,Daowen Wang*. Molecular analysis of phosphomannomutase (PMM) genes reveals a unique PMM duplication event in diverse Triticeae species and the main PMM isozymes in bread wheat tissues. BMC Plant Biology, 10: 214. (2010)

27. Qian-Hua Shen, Yusuke Saijo, Stefan Mauch, Christoph Biskup, Stéphane Bieri, Beat Keller, Hikaru Seki, Bekir ülker, Imre E. Somssich, Paul Schulze-Lefert*. Nuclear Activity of MLA Immune Receptors Links Isolate-Specific and Basal Disease-Resistance Responses. Science, 315:1098-1103. (2007)

28. Qian-Hua Shen, Paul Schulze-Lefert*. Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors. EMBO Journal., 26: 4293-4301. (2007)

29. Qian-Hua Shen, Yusuke Saijo, Stefan Mauch, Nico Tintor, Christoph Biskup, Bekir ülker, Imre E. Somssich, Silke Robatzek and Paul Schulze-Lefert*. Signal Integration in the Plant Immune. Book Chapter in: Biology of Molecular Plant-Microbe Interactions, Volume 6. Editors: Matteo Lorito, Sheri Woo and Felice Scala. (2007)

30. Stephane Bieri, Stefan Mauch, Qian-Hua Shen, Jack Peart, Alessandra Devoto, Catarina Casais, Francesca Ceron, Sabine Schulze, Hans-Henning Steinbi？, Ken Shirasu, and Paul Schulze-Lefert*. RAR1 Positively Controls Steady State Levels of Barley MLA Resistance Proteins and Enables Sufficient MLA6 Accumulation for Effective Resistance. Plant Cell, 16: 3480-3495. (2004)

31. P. Rodrigues, J. M. Garrood, Qian-Hua Shen, P. H. Smith and Lysley. A. Boyd*. The genetics of non-host disease resistance in wheat to barley yellow rust. Theor Appl Genet, 109: 425-432. (2004)

32. Qian-Hua Shen, Fasong Zhou, Stephane Bieri, Thomas Haizel, Ken Shirasu and Paul Schulze-Lefert*. Recognition Specificity and RAR1/SGT1 Dependence in Barley Mla Disease Resistance Genes to the Powdery Mildew Fungus. Plant Cell, 15: 732-744. (2003)