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沈偉

（上海科技大學生命學院副教授）

鎖定
沈偉，男，1985年8月生，漢族，上海市人，研究生，理學博士，2014年7月參加工作，2022年7月加入中國共產黨。
現任上海科技大學生命學院副教授、研究員、博士生導師，學術交流委員會主任。 [1-2] 
中文名
沈偉
國    籍
中國
民    族
漢族
出生日期
1985年8月
畢業院校
清華大學
約翰霍普金斯大學
主要成就
利用果蠅作為模式生物展開對温度受體和機制的研究

目錄

  1. 1 人物經歷
  2. 2 研究方向
  1. 3 主要成就
  2. 4 所獲榮譽
  1. 5 社會任職
  2. 6 代表論文

沈偉人物經歷

2003.08--2007.07，清華大學生物科學與技術系學士
2007.08--2013.02，美國約翰霍普金斯大學生物化學系博士
2013.04--2014.06，美國洛克菲勒大學分子遺傳學系博士後
2014.07--2019.12，上海科技大學生命科學與技術學院助理教授
2019.12--，上海科技大學生命科學與技術學院副教授 [1] 

沈偉研究方向

“神經- 代謝”互作機制與疾病控制 [1] 

沈偉主要成就

1.在《Science》所發表的論文發現了一種新型GPCR 温度受體，被評為近期神經科學的‘top 7’的必讀文章。
2.在《PNAS》所發表的論文中發現了下丘腦負責調節體温與產熱的關鍵神經元；該工作在當期被領域專家評價為‘milestone’的成果。
3.在《Cell Research》所發表的論文中闡明瞭果蠅大腦內部氨基酸感受器促進攝食的分子機制；該工作入選了當期的Research Highlight。
4.在《Nature Neuroscience》所發表的工作是解析攝食和捕食行為背後的動機和獎賞機制；該工作在當期被領域專家評價為“shed new light”和“reveal new insights”的成果。
5.在《Science Advances》所發表的論文揭示了腦幹臂旁外側核兩種熱抵抗神經元差異編碼温度調節變量的機制；為體温調節疾病提供新細胞靶點，也為解碼其它本能行為提供了參考。 [1] 

沈偉所獲榮譽

1. 2022，入選國家自然科學基金“優秀青年”項目
2. 2021，入選上海市“科技創新行動計劃”優秀學術帶頭人（青年）計劃
3. 2021，入選第二屆上海市“創新創業50人論壇”，上海市
4. 2016，2019，2021，入選上海科技大學優秀教師
5. 2017，Nominee for the Helmholtz Young Investigator in Diabetes Award (HelDi Award)，德國亥姆霍茲聯合會
6. 2016，入選上海市浦東新區名人堂，上海市浦東新區
7. 2013，Paul Erlich Award for Young Investigators，約翰霍普金斯大學
8. 2011，中國優秀自費留學生獎學金，中國國家留學基金委 [1] 

沈偉社會任職

上海神經科學學會理事 [1] 

沈偉代表論文

（*第一作者，#通訊作者）
1. Yang,Wen Z*;Xie, Hengchang*;Du, Xiaosa*;Zhou, Qian*;Shen,Wei L#;.A parabrachial-hypothalamic parallel circuit governs cold defense in mice.NATURE COMMUNICATIONS. 15 August 2023.
2. Sun, Hongbin*; Lin, Wei*; Tang, Yu*; Tu, Hongqing*; Chen, Ting; Zhou, Jie; Wang, Dezhong;Xu, Qingqing;Niu, Jianlou;Dong, Wenliya;Liu, Sidan;Ni, Xinyan;Yang, Wen;Zhao, Yingzheng;Ying, Lei;Zhang, Jie;Li, Xiaokun;Moosa Mohammadi;Shen, Wei L#; Huang, Zhifeng#.Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4.Cell Metabolism. 5 May 2023.
3. Zhou, Qian*; Fu, Xin; Xu, Jianhui; Dong, Shiming; Liu, Changhao; Cheng, Dali; Gao, Cuicui; Huang, Minhua; Liu, Zhiduo; Ni, Xinyan; Hua, Rong; Tu, Hongqing; Sun, Hongbin; Shen, Qiwei; Chen, Baoting; Zhang, Jin; Zhang, Liye; Yang, Haitao; Hu, Ji; Yang, Wei; Pei, Weihua; Yao, Qiyuan; Sheng, Xing; Zhang, Jie; Yang, Wen Z.; Shen, Wei L..Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.NEURON;. 01 Feb 2023. 111(3):387-404.e8.
4. Zhou, Qian*; Liu, Changhao; Chen, Ting; Liu, Yanyang; Cao, Ren; Ni, Xinyan; Yang, Wen Z.; Shen, Qiwei#; Sun, Hongbin; Shen, Wei L.#.Cooling-activated dorsomedial hypothalamic BDNF neurons control cold defense in mice.JOURNAL OF NEUROCHEMISTRY. Nov 2022.
5. Bai, Jing*; Zhang, Shuai; Cao, Jinjing; Sun, Hongbin; Mang, Zhiguo; Shen, Wei L.#; Li, Hao#.Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models.PHYTOMEDICINE. 28 Jul 2022. 105.
6. Zeng, Wenwen#*; Yang, Fan#; Shen, Wei L.#; Zhan, Cheng#; Zheng, Peng#; Hu, Ji.Interactions between central nervous system and peripheral metabolic organs.SCIENCE CHINA-LIFE SCIENCES. 01 Jun 2022.
7. Xiao, Wei*; Jiao, Zhuo-Lei; Senol, Esra; Yao, Jiwei; Zhao, Miao; Zhao, Zheng-Dong; Chen, Xiaowei#; Cao, Peng#; Fu, Yu#; Gao, Zhihua#; Shen, Wei L.#; Xu, Xiao-Hong#.Neural circuit control of innate behaviors.SCIENCE CHINA-LIFE SCIENCES. 01 Dec 2021.
8. Yu, Hong*; Xiang, Xinkuan*; Chen, Zongming*; Wang, Xu; Dai, Jiaqi; Wang, Xinxin; Huang, Pengcheng; Zhao, Zheng-dong; Shen, Wei L.#; Li, Haohong#.Periaqueductal gray neurons encode the sequential motor program in hunting behavior of mice.NATURE COMMUNICATIONS. 11 Nov 2021. 12(1).
9. Yang, Wen Z.*; Du, Xiaosa; Zhang, Wen; Gao, Cuicui; Xie, Hengchang; Xiao, Yan; Jia, Xiaoning; Liu, Jiashu; Xu, Jianhui; Fu, Xin; Tu, Hongqing; Fu, Xiaoyu; Ni, Xinyan; He, Miao; Yang, Jiajun; Wang, Hong; Yang, Haitao; Xu, Xiao-hong; Shen, Wei L..Parabrachial neuron types categorically encode thermoregulation variables during heat defense.SCIENCE ADVANCES. Sep 2020. 6(36).
10. Zhao, Zheng-dong*; Chen, Zongming*; Xiang, Xinkuan; Hu, Mengna; Xie, Hengchang; Jia, Xiaoning; Cai, Fang; Cui, Yuting; Chen, Zijun; Qian, Lechen; Liu, Jiashu; Shang, Congping; Yang, Yiqing; Ni, Xinyan; Sun, Wenzhi; Hu, Ji; Cao, Peng; Li, Haohong#; Shen, Wei L.#.Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting.NATURE NEUROSCIENCE. Jun 2019. 22(6):921-932.
11. Shang, Congping*; Liu, Aixue; Li, Dapeng; Xie, Zhiyong; Chen, Zijun; Huang, Meizhu; Li, Yang; Wang, Yi; Shen, Wei L.; Cao, Peng#.A subcortical excitatory circuit for sensory-triggered predatory hunting in mice.NATURE NEUROSCIENCE. Jun 2019. 22(6):909-+.
12. Yuan, Yuan*; Wu, Wei*; Chen, Ming; Cai, Fang; Fan, Chengyu; Shen, Wei; Sun, Wenzhi#; Hu, Ji#.Reward Inhibits Paraventricular CRH Neurons to Relieve Stress.CURRENT BIOLOGY. Apr 2019. 29(7):1243-1251.
13. Yang, Zhe*; Huang, Rui; Fu, Xin; Wang, Gaohang; Qi, Wei; Mao, Decai; Shi, Zhaomei; Shen, Wei L.#; Wang, Liming#.A post-ingestive amino acid sensor promotes food consumption in Drosophila.CELL RESEARCH. Oct 2018. 28(10):1013-1025.
14. Luo, Junjie*; Shen, Wei L.; Montell, Craig#.TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae.NATURE NEUROSCIENCE. Jan 2017. 20(1):34-41.
15. Zhao, Zheng-Dong*; Yang, Wen Z.; Gao, Cuicui; Fu, Xin; Zhang, Wen; Zhou, Qian; Chen, Wanpeng; Ni, Xinyan; Lin, Jun-Kai; Yang, Juan; Xu, Xiao-Hong; Shen, Wei L.#.A hypothalamic circuit that controls body temperature.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 21 Feb 2017. 114(8):2042-2047.
16. Shen, Wei L.*; Kwon, Young; Adegbola, Abidemi A.; Luo, Junjie; Chess, Andrew; Montell, Craig#.Function of Rhodopsin in Temperature Discrimination in Drosophila.SCIENCE. 2011. 331(6022):1333-1336.
17. Kwon, Young*; Shen, Wei L.; Shim, Hye-Seok; Montell, Craig#.Fine Thermotactic Discrimination between the Optimal and Slightly Cooler Temperatures via a TRPV Channel in Chordotonal Neurons.JOURNAL OF NEUROSCIENCE. 2010. 30(31):10465-10471.
18. Xue, Xiaoyu*; Yu, Hongwei; Yang, Haitao; Xue, Fei; Wu, Zhixin; Shen, Wei; Li, Jun; Zhou, Zhe; Ding, Yi; Zhao, Qi; Zhang, Xuejun C.; Liao, Ming; Bartlam, Mark; Rao, Zihe#.Structures of two coronavirus main proteases: Implications for substrate binding and antiviral drug design.JOURNAL OF VIROLOGY. 2008. 82(5):2515-2527.
19. Xue, Xiaoyu*; Yang, Haitao; Shen, Wei; Zhao, Qi; Li, Jun; Yang, Kailin; Chen, Cheng; Jin, Yinghua; Bartlam, Mark; Rao, Zihe#.Production of authentic SARS-CoV M-pro with enhanced activity: Application as a novel tag-cleavage endopeptidase for protein overproduction.JOURNAL OF MOLECULAR BIOLOGY. 2007. 366(3):965-975. [1] 
參考資料