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汪源
（四川大學教授）
鎖定
汪源人物簡介
汪源，四川大學華西生物治療國家重點實驗室研究員、博士生導師
[1-2]
。清華大學學士（2001-2005），密歇根大學博士（2005-2011）、博士後（2011-2013），美國國家兒童醫學中心博士後（2013-2016）
[1-2]
。
課題組通過構建創新腫瘤模型，結合單細胞和空間多組學分析，研究惡性腦瘤、淋巴瘤、卵巢癌等實體腫瘤的發生發展機制，探索腫瘤早期診斷和預防的新策略
[1-2]
。先後以通訊或第一作者在Cell, Nature Cancer, Cancer Cell, Cell Research, Nature Communications, Science Advances等學術期刊發表論文
[5-17]
，榮獲美國兒童腫瘤基金會“Young Investigator Award”、美國國防部“NF研究項目年度突破”，受邀在中國細胞生物學學會年會、中國神經科學學會年會、美國神經學會年會、美國兒童腫瘤基金會年會等國際國內重要學術會議上做大會報作和分組報告
[1-2]
。
現任中國神經科學學會神經幹細胞和組織工程分會委員、神經腫瘤分會委員、中國細胞生物學會青年委員會委員、四川省細胞生物學會理事
[1-2]
。擔任學術期刊National Science Review編輯工作組成員
[3]
、Cancer Letters編委
[4]
。主持國家重點研發計劃青年項目、自然科學基金面上項目和四川省傑出青年科技基金等課題
[1-2]
。
汪源研究方向
汪源代表論文
- Yao, Pengle; Xiao, Peng; Huang, Zongyao; Tang, Min; Tang, Xiwen; Yang, Gaoxia;Zhang, Qi; Li, Xinpei; Yang, Zhengnan; Xie, Chuanxing; Gong, Hui; Wang, Guihua;Liu, Yutong; Wang, Xiuxuan; Li, Huifang; Jia, Da; Dai, Lunzhi; Chen, Lu; Chen, Chong;Liu, Yu; Xiao, Hengyi; Zhang, Yan; Wang, Yuan; Protein-level mutantp53 reporters identify druggable rare precancerous clones in noncancerous tissues, Nature Cancer, 2023 [18-19]
- Ren, Yanming; Huang, Zongyao; Zhou, Lingling; Xiao, Peng; Song, Junwei; He, Ping; Xie, Chuanxing; Zhou, Ran; Li, Menghan; Dong, Xiangqun; Mao, Qing; You, Chao; Xu, Jianguo; Liu, Yanhui; Lan, Zhigang; Zhang, Tiejun; Gan, Qi; Yang, Yuan; Chen, Tengyun; Huang, Bowen; Yang, Xiang; Xiao, Anqi; Ou, Yun; Su, Zhengzheng; Chen, Lu; Zhang, Yan; Ju, Yan; Zhang, Yuekang; Wang, Yuan; Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas, Nature Communications, 2023, 14 [5] [16]
- Ding, Chaoqiong; Yan, Xiang; Xu, Mengying; Zhou, Ran; Zhao, Yuanchun; Zhang, Dan; Huang, Zongyao; Pan, Zhenzhong; Xiao, Peng; Li, Huifang; Chen, Lu; Wang, Yuan; Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages, Scientific Data, 2022, 9(69) [8]
- Wang, Xiaofei; Zhou, Ran; Xiong, Yanzhen; Zhou, Lingling; Yan, Xiang; Wang, Manli; Li, Fan; Xie, Chuanxing; Zhang, Yiming; Huang, Zongyao; Ding, Chaoqiong; Shi, Kaidou; Li, Weida; Liu, Yu; Cao, Zhongwei; Zhang, Zhen-Ning; Zhou, Shengtao; Chen, Chong; Zhang, Yan; Chen, Lu; Wang, Yuan; Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma, Cell Research, 2021, 31(6): 684-702 [9] [17]
- Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan; Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1, eLife, 2014, 3 (共同一作) [12]
- 參考資料
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- 1. 四川大學生物治療國家重點實驗室 汪源 ．四川大學生物治療國家重點實驗室[引用日期2023-07-02]
- 2. 四川大學 汪源 ．四川大學教師個人主頁[引用日期2023-07-02]
- 3. 編委會 ．National Science Review[引用日期2023-07-02]
- 4. 編委會 ．Cancer Letters[引用日期2023-07-02]
- 5. Spatial transcriptomics reveals niche-specific enrichment and vulnerabilities of radial glial stem-like cells in malignant gliomas ．Nature Communications[引用日期2023-07-02]
- 6. Modeling nervous system tumors with human stem cells and organoids | Cell Regeneration | Full Text ．Cell Regeneration[引用日期2023-07-02]
- 7. Crosstalk between m6A regulators and mRNA during cancer progression ．Oncogene[引用日期2023-07-02]
- 8. Short-read and long-read full-length transcriptome of mouse neural stem cells across neurodevelopmental stages ．Scientific Data[引用日期2023-07-02]
- 9. Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma ．Cell Research[引用日期2023-07-02]
- 10. Plasma cells shape the mesenchymal identity of ovarian cancers through transfer of exosome-derived microRNAs ．Science Advances[引用日期2023-07-02]
- 11. A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications ．Frontiers of Medicine[引用日期2023-07-02]
- 12. Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1 | eLife ．eLife[引用日期2023-07-02]
- 13. ERK Inhibition Rescues Defects in Fate Specification of Nf1-Deficient Neural Progenitors and Brain Abnormalities ．Cell[引用日期2023-07-02]
- 14. Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model ．Cancer Cell[引用日期2023-07-02]
- 15. Cell Regen l 基於人源幹細胞／類器官的神經系統腫瘤新模型 ．澎湃新聞[引用日期2023-07-02]
- 16. 我院神經外科與生物治療國重團隊合作在Nature Communications發文：闡明惡性膠質瘤空間轉錄剪接特徵和侵襲性生長新機制 ．四川大學華西醫院[引用日期2023-07-02]
- 17. 汪源團隊在Cell Research發文解析老年惡性腦瘤的發生機制和潛在早期干預時間窗口 ．四川大學疾病分子網絡前沿科學中心[引用日期2023-07-02]
- 18. Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues ．Nature Cancer[引用日期2023-08-09]
- 19. 我校生物治療國重汪源團隊在Nature Cancer發文 ．四川大學[引用日期2023-08-09]
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