江一舟

2015.6-至今 深圳大學高等研究院，研究員。

2011.9-2015.5美國賓夕法尼亞大學病理系,博士後,Research Associate.

2006.9-2011.8美國威斯康辛大學麥迪遜分校婦產系,研究助理。

2011-2015:博士後,美國賓夕法尼亞大學,病理系，醫學與工程學研究所。

2006-2011:博士，美國威斯康辛大學麥迪遜分校,醫學與公共衞生學院,內分泌生殖生理學。

2004-2006: 保送研究生，中國廈門大學生命科學學院,生物化學。

2000-2004: 學士,中國廈門大學生命科學學院,生物系 ^[1]  。

1.代謝與心血管穩態。

2.DNA和RNA的功能性修飾與表觀遺傳學。

3.上皮組織修復再生和靶向治療 ^[1]  。

科研經費 （主持）

1.2017年-2019年，深圳市海外孔雀計劃B類高層次人才創新基金，項目經費450萬。

2.2018年-2019年，深圳市孔雀計劃技術創新，項目名稱：RNA甲基化表觀修飾酶的功能和心血管藥

物研發。項目經費80萬。

3.2019年-2021年，深圳科技創新委-基礎研究，項目名稱：酶激活腫瘤血管靶向前體藥物。項目經費

50萬。

4.2016年-2018年, 國家自然科學基金委青年科學基金項目，項目名稱：內皮細胞FOXO1的功能和表

觀調控機制。項目經費21.6萬

5.2017年-2018年，深圳科技創新委-基礎研究，項目名稱：表觀複合體調控動脈粥樣硬化。項目經費

50萬 ^[1]  。

姚修瑞，原阿里巴巴新媒體事業部負責人、課題組Lab Manager，專長：科研成果轉化。

朱鑫星，博士，廈門大學生命科學學院，專長：基因調控和細胞信號轉導。

閻亞偉，博士，中國醫科大學基礎醫學院，專長：疾病動物模型。

艾純芝，博士，中科院大連物理化學研究所，專長：虛擬藥物篩選。

陳度楚，博士，廈門大學生命科學學院，專長：基因調控和表觀遺傳。

Yasmeen Saeed，博士，北京理工大學生命科學學院，專長：空間生命科學。

黃廣誠，博士，中科院長春應用化學研究所，專長：材料化學 ^[1]  。

人才培養

2.閻亞偉博士（2016年6月–2018年6月），2016年11月10號獲得中國博士後科學基金第60批面上二等

資助。

3.艾純芝博士（2017.1.6進站-至今），2017年11月13號獲得中國博士後科學基金第62批面上二等資

助。

4.王譯責，深大高研院2018屆優秀本科畢業論文獎。

5.温婕琪，深大高研院2019屆本科畢業論文論壇獎。

學術論文

1.Chen DM, Huang ZX, Chen DC, Zhu XX, Yan YW, Ai CZ, Tang S, Madhavan S, Ni W, Huang ZP, Li W, Ji W, Shen H,Jiang YZ*. Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma. Bone Res. 2018 Apr 4.

2.Zhu X, Chen D, Liu Y, Yu J, Qiao L, Lin S, Chen D, Zhong G, Lu X, Wang Y, Wen J, Zhong X,Jiang Y. LncRNA HOXA-AS3 integrates NF-κB signaling to regulate endothelium inflammation. Mol Cell Biol. 2019 Jul 8.

3.Lin S, Liu Q,Jiang YZ, Gregory R. Nucleotide resolution profiling of m7G tRNA modifications by TRAC-Seq. Nature Protocol.2019 Oct 16.

4.Wu M, Sheng L, Cheng M, Zhang H,Jiang Y, Lin S, Liang Y, Zhu F, Liu Z, Zhang Y, Zhang X, Gao Q, Chen D, Li J, Li Y. Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells. Oncogene. 2019 Jul.

5.Zhu X, Liu Y, Yu J, Du J, Guo R, Feng Y, Zhong G,Jiang Y*, Lin J*. LncRNA HOXA-AS2 represses endothelium inflammation by regulating the activity of NF-κB signaling. Atherosclerosis. 2019 Feb.

6.Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AJ,Jiang YZ, He Y, Ruan X, Lu X. (Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice from Diet-Induced Obesity and Hepatosteatosis. Circ Res. 2018 Mar 2.

7.Davies PF, Manduchi E, Jiménez JM,Jiang, YZ. 2017. Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression. J. Biomech. 2017.

8.Wu Y, Xie L, Wang M, Xiong Q, Guo Y, Liang Y, Li J, Sheng R, Deng P, Wang Y, Zheng R,Jiang Y, Ye L, Chen Q, Zhou X, Lin S, Yuan Q. Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. Nature Communication. 2018 Nov 14.

9.Yuan Q, Zhou CC, Xiong QC, Zhu XX, Zou J, Li XB, Cheng L,Jiang YZ, and Zou SJ. AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs. Bone Res. 2017 Sep 26.

10.Chen DC, Liang YD, Wang YZ, Ai CZ, Zhu XX, Yan YW, Saeed Y, Yu B, Huang JY, Gao YX, Liu JQ,Jiang YZ, Liu M, Chen DM. CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma. Cancer Cell Int. 2017 Nov .

11.Ai CZ, Liu Y, Li W, Chen DM, Zhu XX, Yan YW, Chen DC,Jiang YZ*. Explanation for Bioactivation Mechanism of Targeted Anticancer Agents Mediated by Cytochrome P450s: A Case of Erlotinib. Plos One. 2017 Jun 19.

12.Peng L, Linghu R, Chen D, Yang J, Kou X, Wang XZ, Hu Y,Jiang YZ*, Yang J. Inhibition of Glutathione Metabolism Attenuates Esophagus Cancer Progression. Experimental and Molecular Medicine.

13.Zhu XX, Yan YW, Chen D, Ai CZ, Xu SS, Wang XZ, Zhong GS, Lu X, Jiang YZ*. Jarid2 is Essential for the Maintenance of Tumor Initiating Cells in Bladder Cancer. Oncotarget. 2017.

14.Zhu XX, Yan YW, Chen D, Ai CZ, Lu X, Xu SS, Jiang S, Zhong GS, Chen DB,Jiang YZ*.Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells. Oncotarget. 2016.

15.Zhong XQ,Jiang YZ#, Liu P, He WZ, Xiong ZT, Chang WJ, Zhu JD, Cui QL. Toll-like 4 receptor /NFκB inflammatory/miR-146a pathway contributes to the ART-correlated preterm birth outcome.Oncotarget. 2016.

16.Chen DM, Zhong XQ, Wang K,Jiang YZ*. SWI/SNF Chromatin Remodeling Complex in Regulating Mesenchymal Stem Cell Lineage Specification. J Tissue Sci Eng 2015.

17.Chen D, Dai C,Jiang Y*. Histone H2A and H2B Deubiquitinase in Developmental Disease and Cancer. Cancer Transl Med. 2015.

18.McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd,Jiang YZ, Stoeckert CJ, Barker AJ, Yoon S, Markl M, Davies PF. 2017. Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. J. Biomech. 2017.

19.Li Y, Wang K, Zou QY,Jiang YZ, Zhou C, Zheng J. ITE Suppresses Angiogenic Responses in Human Artery and Vein Endothelial Cells: Differential Roles of AhR. Reprod Toxicol. 2017 Dec.

20.McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH ,Jiang YZ, Stoeckert CJ , Barker AJ, Markl M, Davies PF. Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc. 2016 Apr 18.

21.Jiang YZ, Manduchi E, Jiménez JM, Davies PF. Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arteriosclerosis Thrombosis and Vascular Biology. 2015 Jun.

JCR 1區.Top期刊.

22.Jiang YZ*, Manduchi E*, Stoeckert CJ, Davies PF. Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 2015.

23.Jiang YZ, Jiménez JM, Ou K, McCormick ME, Davies PF. Hemodynamic disturbed flow induces differential DNA methylation of endothelial Kruppel-Like Factor 4 promoter in vitro and in vivo. Circulation Research.

24.Davies PF.,Jimenez JM, Manduchi E, Stoeckert CJ,Jiang YZ. Emerging topic: flow-related epigenetic regulation of the atherosusceptible endothelial phenotype through DNA methylation. Vascular Pharmacology 2014.

25.Jiménez JM, Prasad V, Yu M, Kampmeyer C, Kaakour A-H, Wang P, Maloney SF, Wright N, Johnston I,Jiang YZ, Davies PF. Macro- and micro-scale hemodynamics of model coronary stents: Strut geometry, fibrin deposition and thrombomodulin expression. Journal of the Royal Society Interface. 2014.

26.Wang K,Jiang YZ, Chen DB, Zheng J. Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation,2009.

27.Jiang YZ*, Wang K*, Fang R, Zheng J. Expression of aryl hydrocarbon receptor in human placentas and fetal tissues. Journal of Histochemistry&Cytochemistry. 2010.

28.Jobe SO, Ramadoss J, Koch JM,Jiang Y, Zheng J, Magness RR. Estradiol-17β and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension. 2010.

29.Dai CF,Jiang YZ, Zheng J. Expression and Roles of Slit-Robo System in Human Ovarian Cancer. Histochemistry and Cell Biology. 2011.

30.Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Transcriptional and Functional Adaptations of Human Endothelial Cells to Physiological Chronic Low Oxygen. Biology of Reproduction. 2013.

31.Jiang YZ, Wang K, Li Y, Dai CF, Wang P, Kendziorski C, Chen DB, Zheng J. Enhanced Cellular Responses and Distinct Gene Profiles in Human Fetoplacental Artery Endothelial Cells under Chronic Low Oxygen. Biology of Reproduction. 2013.

32.Wang K, Li Y,Jiang YZ, Dai CF, Patankar MS, Song JS, Zheng J. An endogenous aryl hydrocarbon receptor ligand inhibits proliferation and migration of human ovarian cancer cells. Cancer Letters. 2013 Oct 28.

33.Jiang YZ, Li Y, Wang K, Dai CF, Huang SA, Chen DB, Zheng J. Distinct Roles of HIF1A in Endothelial Adaptations to Physiological and Atmospheric Oxygen. Molecular & Cellular Endocrinology. 2014 Jun 25.

34.Li Y, Wang K,Jiang YZ, Dai CF, Zheng J.2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD) Inhibits Human Ovarian Cancer Cell Proliferation. Cellular Oncology. 2014 Dec.

會議口頭報告

1.2015，美國心臟協會，動脈粥樣硬化、血栓、外周血管生物學研討會，美國舊金山

題目: Hypercholesterolemia suppresses carotid artery endothelial NOS3 expression via epigenetic mechanisms.

2.2014，英國動脈粥樣硬化協會，系統生物學與動脈粥樣硬化研討會，英國劍橋

題目: Differential DNA Methylation Patterns Of Athero-Susceptible And Protected Endothelial Phenotypes In Vivo: Epigenomic Code In Arterial Endothelial Methylome.

3.2014，第九屆國際生物力學、血管生物學與心血管疾病研討會，加拿大蒙特利爾

題目: Differential DNA methylation of endothelial Kruppel-like Factor 4 (KLF4) promoter in response to hemodynamic disturbed flow in vitro and in vivo ^[1]  .

2017：深圳大學高水平論文獎一等獎。

2016：深圳大學高水平論文獎一等獎。

2013：美國心臟協會卓越研究獎。

2011：58屆婦產科研究年會 Vilas 會議報告獎。

2010：43屆生殖學研究年會Larry Ewing Memorial 會議報告獎。