楊根生

納米靶向藥物遞送系統

經皮給藥新劑型 ^[1] 

3D打印製劑新工藝新技術

承擔《細胞分子生物學》、《製劑工程》、《高等藥劑學》和《遞藥系統新進展》等課程主講工

累計指導研究生近100人 ^[1] 

分別於2006和2018獲評“浙江工業大學我最喜愛老師”榮譽稱號

多次指導研究生獲得“校優秀畢業論文”、“校優秀畢業生”和國家獎學金等榮譽

1. 國家自然科學基金委員會，面上項目，22078297，靶點特異性程序化響應生物分子馬達遞送系統構建及機制研究，2021-01至2024-12，63萬元，在研，主持

2. 國家自然科學基金委員會，面上項目，21376223，參與酶切肽腫瘤特異性改性脂質體與聚環酯增載親脂藥物控釋納米粒的製備及性能研究，2013-01至2017-12，80萬元，結題，主持

3. 浙江省自然科學基金委員會，一般項目，LY19B060012，多藥共給的智能酶響應雜化納米粒聯合抗腫瘤治療給藥體系研究，2019-01至2021-12，10萬元，在研，主持

4. 企業橫向，KYY-HX-20200670，藥物納米遞送系統的開發，2020-08至2024-07，100萬元，在研，主持

5. 企業橫向，KYY-HX-20210466，氨碘肽滴眼液藥效學深度研究與技術開發，2021-04至2022-04，15萬元，在研，主持

6. 青海省科技合作專項，2017-HZ-814，槲皮素-月桂酸共軛物納米膠束的製備及提高生物利用度的研究，2017-09至2019-12，8萬元，結題，主持

7. 企業橫向，KYY-HX-20200670，藥物納米遞送系統的開發，2020-08至2024-07，100萬元，在研，主持

8. 國家自然科學基金委員會，青年項目，51803181，腫瘤乏氧微環境靶向細菌遞藥微機器人的構建及其抗結腸癌作用研究，2019-01至2021-12，25萬元，在研，參與

9. 國家自然科學基金委員會，青年項目，21808216，多尺度下超細粉靜電沉積構建滲透泵包衣膜機制研究，2019-01至2021-12，21萬元，在研，參與

10. 浙江省自然科學基金委員會，一般項目，LY20H300006，光“觸發式”智能釋藥納米載體用於腫瘤深層遞藥研究，2020-01至2022-12，9萬元，在研，參加

11. 浙江省自然科學基金，一般項目，LY20B060007，3D打印仿生微流控經皮遞藥系統研究，2020.01至2022.12，9萬元，在研，參與 ^[1] 

12. 企業橫向，乾粉吸入製劑藥效學研究與技術開發，2021.03-2023.12，200萬元，在研，參與

13. 企業橫向，KYY-HX-20210858，基於蛋白冠的靶向納米遞送系統的開發，2021-09至2025-09，100萬元，在研，參加

[1] Fangyuan Guo; Nan Yu; Yunlong Jiao; Weiyong Hong; Kang Zhou; Xugang Ji; Huixing Yuan; Haiying Wang; Aiqin Li; Guoping Wang; Gensheng Yang*; Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer, Drug Delivery, 2021, 28(1):1709-1721.

[2] Fangyuan Guo; Qiafan Fu; Kang Zhou; Chenghao Jin; Wenchao Wu; Xugang Ji; Qinying Yan; Qingliang Yang; Danjun Wu; Aiqin Li; Gensheng Yang*; Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy, Journal of Nanobiotechnology, 2020, 18: 48.

[3] Guo, Fangyuan; Fu, Qiafan; Jin, Chenhao; Ji, Xugang; Yan, Qinying; Yang, Qingliang; Wu, Danjun; Gao, Ying; Hong, Weiyong; Li, Aiqin; Yang, Gensheng*; Dual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment , Drug Delivery, 2019, 26(1):1027-1038.

[4] Weiyong Hong; Ying Gao; Bang Lou; Sanjun Ying; Wenchao Wu; Xugang Ji; Nan Yu; Yunlong Jiao; Haiying Wang; Xuefeng Zhou; Anqin Li; Fangyuan Guo*; Gensheng Yang*; Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model, International Journal of Nanomedicine, 2021, 16: 4147-4159

[5] Weiyong Hong*; Fangyuan Guo*; Nan Yu; Sanjun Ying; Bang Lou; Jiangqing Wu; Ying Gao; Xugang Ji; Haiying Wang; Aiqin Li; Guoping Wang; Gensheng Yang; A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment, Drug Design, Development and Therapy, 2021, 15: 2843–2855

[6]cFangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Weiyong Hong, Gensheng Yang. PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors[J]. Journal of Nanobiotechnology. 2018, 16: 57.

[7] Fangyuan Guo, Dongxue Huang, Wei Zhang, Qinying Yan, Qingliang Yang, Yan Yang, Hanbing Li, Junxian Yun, Weiyong Hong, Gensheng Yang. Star-shaped polyester-based elastomers as an implantable delivery system for insulin: Development, pharmacokinetics, pharmacodynamics, and biocompatibility[J]. Materials Sience and Engineering C. 2018, 84, 180-187.

[8] Guo fangyuan, Dingjia Guo, Wei Zhang, Minli Yao, Junxian Yun, Gensheng Yang. Preparation of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles by a microchannel technology, European Journal of Pharmaceutical Sciences, 2017, 99: 328-336.

[9] Fangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Hanbing Li, Junxian Yun, Gensheng Yang. Biodegradable star-shaped polycyclic ester elastomers: preparation, degradability, protein release, and biocompatibility in vitro[J]. Journal of Bioactive and Compatible Polymers. 2017, 32(2): 178-195.

[10] Fangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Weiyong Hong, Gensheng Yang. Synthesis, characterization and cytotoxicity of star-shaped polyester-based elastomers as a controlled release system for protein[J]. Journal of Applied Polymer Science. 2016, 133(18), DOI: 10.1002/app.43393

[11] Qingliang Yang, Feng Yuan, Jiale Chen, Hang Zhou, Gensheng Yang*, Jesse Zhu^*., Delayed sustained drug release from electrostatic powder coated tablets with ultrafine polymer blends. Powder Technology, 2021, 394, 496-503. doi.org/10.1016/j.powtec.2021.08.088

[12] Lei Xu, Qingliang Yang *, Wei Qiang, Huijie Li, Weizhen Zhong, Siying Pan, Gensheng Yang *, Hydrophilic excipient-independent drug release from SLA-printed pellets, Pharmaceutics, 2021, 13, 1717.

[13] Qingliang Yang, Ying Gao, Lei Xu, Weiyong Hong, Yuanbin She, Gensheng Yang*. Enzyme-driven micro/nanomotors: Recent advances and biomedical applications, International Journal of Biological Macromolecules. 2021,167: 457-469. doi.org/10.1016/j.ijbiomac.2020.11.215

[14] Qingliang Yang, Weizhen Zhong, Lei Xu, Huijie Li, Qinying Yan, Yuanbin She, Gensheng Yang*. Recent progress of 3D-printed microneedles for transdermal drug delivery, International Journal of Pharmaceutics, 2021, 593,120106. doi.org/10.1016/j.ijpharm.2020.120106

[15] Qingliang Yang, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang^*. Recent Advances in Motion Control of Micro/Nanomotors. Advanced Intelligent Systems, 2020, 2(8), 2000049. doi.org/10.1002/aisy.202000049

[16] Qingliang Yang, Feng Yuan, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang^*, Jesse Zhu^*., Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine powders. Powder Technology, 2020, 366, 701-708. doi.org/10.1016/j.powtec.2020.03.023

[17] Qingliang Yang, Feng Yuan, Lei Xu, Qinying Yan, Yan Yang, Danjun Wu, Fangyuan Guo, Gensheng Yang^*. An update of moisture barrier coating for drug delivery, Pharmaceutics, 2019, 11(9), 436. doi:10.3390/pharmaceutics11090436

[18] D. Wu, S. Xu, X. Zhang, Y. Li, W. Zhang, Q. Yan, Q. Yang, F. Guo, G. Yang^*. A near-infrared laser-triggered size-shrinkable nanosystem with in situ drug release for deep tumor penetration. ACS Applied Materials & Interfaces, 2021,13，16036−16047.

[19] D. Wu, Y. Li, L. Zhu, W. Zhang, S. Xu, Y. Yang, Q. Yan, G. Yang^*. A biocompatible superparamagnetic chitosan-based nanoplatform enabling targeted SN-38 delivery for colorectal cancer therapy. Carbohydrate Polymers, 2021, 274, 118641.

[20] D. Wu, L. Zhu, Y. Li, X. Zhang, S. Xu, G. Yang^*, T. Delair^*. Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review. Carbohydrate Polymers, 2020, 238, 116126.

[21] D. Wu, L. Zhu, Y. Li, H. Wang, S. Xu, X. Zhang, R. Wu, G. Yang^*. Superparamagnetic chitosan nanocomplexes for colorectal tumor-targeted delivery of irinotecan. International Journal of Pharmaceutics, 2020, 584, 119394.

[22] Yan, QY, Weng, JQ, Wu, XQ, Wang, WW, Yang, QL, Guo, FY, Wu, DJ, Song, Y, Chen, F, Yang, GS. Characteristics, Cryoprotection Evaluation and In Vitro Release of BSA-Loaded Chitosan Nanoparticles, MARINE DRUGS, 2020, 18(6): 315

[23] Yan, QY, Wang, WW, Weng, JQ, Zhang, ZH, Yin, LN, Yang, QL, Guo, FY, Wang, XG, Chen, F, Yang, GS. Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease, DRUG DELIVERY, 2020, 27(1): 1147-1155

[24] Wu, WC, Wu, JQ, Fu, QF, Jin, CH, Guo, FY, Yan, QY, Yang, QL, Wu, DJ, Yang, Y, Yang, GS. Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14: 4683-4695

[1] 郭鈁元，嚴琴英，郭定佳，洪偉勇，楊根生. 一種薑黃素脂質納米粒懸浮液或納米粒的製備方法，中國專利，ZL 2013 1 0723889.1

[2] 楊根生，郭鈁元，蔡為明，洪偉勇. 一種頭孢地嗪酸側鏈中間體的合成方法, 中國專利, ZL 2011 1 0338870.6 2015

[3] 郭鈁元，楊根生，嚴琴英，洪偉勇. 一種硫酸頭孢喹肟的製備方法，中國專利，ZL 2014 1 0209739.3

[4] 楊根生，郭鈁元，張瑋，貟軍賢. 一種聚環酯彈性體的製備方法. 中國專利，ZL 2015 1 0248785.9

[5] 楊根生; 金成浩; 郭鈁元; 馬玉花; 一種通過十二酰氯修飾的槲皮素衍生物及其合成方法, 2021-04-09, 中國, ZL201910314568.3.

[6] 楊根生; 金成浩; 郭鈁元; 馬玉花; 一種槲皮素衍生物及其製備方法, 2021-06-22, 中國, ZL201910315123.7.

[7] 郭鈁元; 楊根生; 吳文超; 吳江青; 黃冬雪; 張逸菲; 一種具有酶靶向性的星狀給藥納米粒的製備, 2020-06-30, 中國, ZL201710694178.4.

[8] 楊根生; 郭鈁元;黃冬雪; 一種聚己內酯-環糊精給藥納米粒的製備方法, 2020-04-24, 中國, ZL201710436906.1.

[9] 郭鈁元; 楊根生; 黃冬雪; 袁怡琦; 韓寧; 周雨青; 朱珊; 洪偉勇; 一種聚四己內酯-季戊四醇給藥納米粒的製備方法, 2020-04-24, 中國, ZL201710436911.2.

[10] 郭鈁元; 楊根生; 黃冬雪; 張逸菲; 一種酶敏感性兩親性聚酯MePEG-Peptide-PER-CL給藥納米粒的製備方法, 2020-04-07, 中國, ZL201710694241.4.

[11] 郭鈁元; 楊根生; 貟軍賢; 洪偉勇; 一種聚三己內酯-丙三酸給藥納米粒的微通道製備方法, 2020-02-21, 中國, ZL201710436916.5. ^[1] 

[1] 楊根生, 歐志敏, 郭鈁元. 《生物藥物合成學》，浙江大學出版社，2012