松胞菌素B

中文名稱:松胞菌素B ^[1] 

中文別名:細胞鬆弛素B

英文名稱:Cytochalasin B

英文別名:(E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione; 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-; 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-; 7,20-Dihydroxy-10-phenyl-5,16-dimethyl-24-oxa-(14)cytochalas-6(12),13,21-trien-23-one; BRN 1096207; CCRIS 9284; HSDB 3479; Phomin; 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E)-(5S,9R,12aS,13S,15S,15aS,16aS,18aS)-; 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-; 2H-Oxacyclotetradecino(2,3-d)isoindole-2,18(5H)-dione, 6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-16-(phenylmethyl)-, (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-; 7(S),20(R)-Dihydroxy-16(R)-methyl-10-phenyl-24-oxa(14)cytochalasa-6(12),13(E),21(E)-triene-1,23-dione; 16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5R,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5S,9R,11E,12aS,13S,15S,15aS,16S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione; (3E,5S,9R,11E,12aS,13S,15S,18aS)-16-benzyl-5,13-dihydroxy-9,15-dimethyl-14-methylidene-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-2H-oxacyclotetradecino[2,3-d]isoindole-2,18(5H)-dione

CAS:14930-96-2

EINECS:239-000-2

分子式:C29H37NO5

分子量:479.6078

松胞菌素B；松胞素B；細胞分裂抑素B；針狀結晶。通常情況下穩定。不溶於水。熔點218～221℃。有毒。本品應密封於0℃以下乾燥保存。C29H37NO3。從真菌類Helminthosporium de－mariodeum中分離得到的代謝產物。是以希臘語的cytos（細胞）和chalasis（鬆弛）組合而命名的。在許多動植物細胞的細胞運動中，特別是可逆地抑制同微絲繫有關的現象。例如在0.5—1.0微克/毫升濃度下作用24小時，會使鼠的培養纖維芽細胞只進行核分裂，而細胞質的分裂受到抑制，從而成為多核細胞。5微克/毫升可阻止蛙的受精卵的卵裂溝的形成，致使不能進行正常的卵裂，也抑制淋巴球、海膽卵、肺上皮細胞等的細胞質分裂，還阻止原腸陷入（海膽、螠蟲等），雞的第五天的雛雞輸卵管的管狀腺的形成，唾液腺的形成，阻止因胚神經索的生長圓錐的運動引起的伸長等，阻止發育、形態形成等過程。此外，還阻害遊離細胞的移動，分離胚細胞的相互選別，阻止細胞向玻璃面上粘着和白血球的吞食作用、血小板的凝集、血餅的收縮、生長激素的釋放、甲狀腺素的分泌等。對於植物來説，30微克/毫升，1小時以內可以使燕麥的孑葉鞘和車軸藻的原生質流動完全停止。在這些情況下，用電子顯微鏡觀察，常能見到微絲的鏡相變化，其他已知細胞鬆弛素B還可抑制糖的輸送，可以考慮細胞鬆弛素B與細胞膜間的相互作用。此外還分離出數種具有類似結構和功能的物質，分別命名為細胞鬆弛素A、C、D、E、F。