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杜敏

（美國華盛頓州立大學教授）

鎖定
男，博士，博士生導師，1969年出生於浙江金華，現就職於美國華盛頓州立大學動物科學系任教授。在國際重要學術會議上做會議邀請報告50餘次。主要從事幹細胞向脂肪和肌肉細胞分化的表觀遺傳學調控研究，及其對動物生產效率和人類健康的影響。 [1] 
中文名
杜敏
出生日期
1969年
出生地
浙江金華
性    別
男

目錄

  1. 1 教育背景
  2. 2 專業經歷
  3. 3 研究領域
  1. 4 承擔項目
  2. 5 發表論文
  3. 6 撰寫著作
  1. 7 聯繫方式

杜敏教育背景

2001/12 - 2003/08: 加拿大阿爾伯塔大學醫學院生物化學系博士後，細胞信號傳導方向
1998/05 - 2001/12: 美國愛荷華州立大學動物科學系和食品科學與人類營養系雙專業博士學位，
研究方向：肌肉生物學與肉品科學/食品科學與技術
1990/09 - 1993/07: 中國農業大學食品科學學院，碩士學位，研究方向：肉品科學和肌肉生物學
1986/09 - 1990/07: 浙江大學食品科學與技術系，獲食品科學學士學位 [1] 

杜敏專業經歷

2013/08 - Present: 美國華盛頓州立大學藥理學系兼職教授
2011/11 - Present: 美國華盛頓州立大學動物科學系特別資助教授
2009/07 - 2011/10: 美國懷俄明大學動物科學系發育生物學科研團隊負責人
2003/08 - 2011/10: 美國懷俄明大學動物科學系肌肉生物學助理教授和副教授
2001/10 - 2003/07: 加拿大阿爾伯塔大學醫學院生物化學系博士後，研究方向：細胞信號傳導
1998/05 - 2001/12: 愛荷華州立大學動物科學系研究助理
1997/09 - 1997/12: 德國聯邦肉類研究中心技術研究所訪問科學家
1995/05 - 1998/05: 中國農業大學食品科學學院分子肌肉生物學實驗室主任
1993/07 - 1998/05:中國農業大學食品科學學院肉品科學和肌肉生物學系任講師 [1] 

杜敏研究領域

1. 營養調控與骨骼肌和脂肪組織發育
2. 間充質多潛能幹細胞分化為脂肪和骨骼肌的表觀遺傳學機理
3. 胎兒發育對動物生產效率和肉品質及人類健康的長期影響 [1] 

杜敏承擔項目

  1. Du, M. (PI), and M. J. Zhu. NIH (R01HD067449). Maternal obesity, AMPK and fetal brown adipogenesis. (8/1/2017-7/31/2022). [2] 
  2. Zhang, H., and M. Du (Co-PI). NIH (R15AA024284). Mechanism of chronic alcohol consumption-induced cancer associated cachexia. (01/01/2017-12/31/2020). [3] 
  3. Du, M. (PI), J. S. Neibergs, D. A. Llewellyn, J. R. Busboom, and M. L. Nelson. USDA-NIFA (2016-68006-24634), High quality beef – a niche market for small and medium sized farms. (1/1/2016-12/31/2019). [4] 
  4. Du, M.(PI), J. R. Busboom, and M. L. Nelson.USDA-NIFA (2015-67015-23219), Vitamin A, Zfp423 and intramuscular adipogenesis in beef cattle. (4/1/2015-3/31/2019). [5] 
  5. Du, M.(PI). USDA-NIFA (HATCH, WNP00796). Deciphering mechanisms regulating intramuscular adipogenesis and fibrogenesis in beef cattle. (3/2012-2/2017). [6] 
  6. Du, M.(PI),NIH(1R01HD067449). AMP-activated protein kinase in cell differentiation during muscle development affected by maternal obesity. (2011/1-2015/12). [7] 

杜敏發表論文

全部論文可訪問Google學術個人主頁
  • Son, J., X. Liu, Q. Tian, L. Zhao, Y. Chen, Y. Hu, S. A. Chae, J. M. Deavila, M. J. Zhu, and M. Du. (2019). Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth. Journal of Physiology, 597: 3333-3347.
  • Zhao, L., Y. Huang, and M. Du. (2019). Farm Animals for Studying Muscle Development and Metabolism: dual purposes for animal production and human health. Animal Frontiers, 9:3.
  • Wei, S., A. Li, L. Zhang, and M. Du. (2019). Long noncoding RNAs in adipogenesis and adipose development of meat animals. Journal of Animal Science, 97: 2644-2657.
  • Wang, H., Y. Chen, X. Mao, and M. Du. (2019). Maternal obesity impairs fetal mitochondriogenesis and brown adipose tissue development partially via upregulation of miR-204-5p. BBA-Molecular Basis of Disease, 1865: 2706-2715.
  • Wang, H., X. Mao, and M. Du. (2019). Phytanic acid activates PPARa to promote beige adipogenic differentiation of preadipocytes. Journal of Nutritional Biochemistry, 67: 201-211.
  • Chen, Y., Y. Yang, and M. Du. (2018). Beyond brown adipogenesis the inheritance of imprinted H19. Non-coding RNA Investigation, 2:64.
  • Wang, B., C. L. Harris, W. Nie, X. Fu, J. M. Deavila, M. J. Zhu, M. Maquivar, S. M. Parish, J. R. Busboom, M. L. Nelson, and M. Du. (2018). Neonatal vitamin A injection promotes cattle muscle development and increase oxidative muscle fibers. Journal of Animal Science and Biotechnology, 9: 82.
  • Zhu, M.J., X. Sun, and M. Du. (2018). AMPK in regulation of apical junctions and barrier junction of intestinal epithelium. Tissue Barriers, 6: 1-13.
  • Harris, C. L., B. Wang, J. M. Deavila, J. R. Busboom, M. Maquivar, S. M. Parish, B. McCann, M. L. Nelson, and M. Du. (2018). Vitamin A administration at birth promotes calf growth and marbling fat development in Angus beef cattle. Journal of Animal Science and Biotechnology, 9: 55.
  • Ma, Y.N., B. Wang, Z.X. Wang, N. A. Gomez, M. J. Zhu, and M. Du. (2018). Three dimensional spheroid culture of adipose stromal vascular cells for studying adipogenesis in beef cattle. Animal, 12: 2123-2129.
  • Zhao, L., T. Zou, N. A. Gomez, B. Wang, M. J. Zhu, and M. Du. (2018). Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1. Nutrition & Diabetes, 8: 39.
  • Zou, T., B. Wang, Q. Yang, J. M. de Avila, M. J. Zhu, J. You, D. Chen, and M. Du. (2018). Raspberry promotes brown and beige adipocyte development in mice fed high-fat diet through activation of AMP-activated protein kinase (AMPK) a1. Journal of Nutritional Biochemistry, 55: 157.
  • Zhu, M. J., Kang, Y., Y. Xue, X. Liang, M. P. Gonzalez Carcia, D. Rodgers, D. K. Kagel, and M. Du. (2018). Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice. Journal of Nutritional Biochemistry, 53:96-103.
  • Wang, B., F. Zhang, H. Zhang, Z. Wang, Y. Ma, M. J. Zhu, and M. Du. (2017). Alcohol intake aggravates adipose browning and muscle atrophy in cancer associated cachexia. Oncotarget, 8: 100411-100420.
  • Wang, B., X. Fu, X. Liang, J. M. Deavila, Z. Wang, L. Zhao, Q. Tian, J. Zhao, N. A. Gomez, S. C. Trombetta, M. J. Zhu, and M. Du. (2017). Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRa+ adipose progenitors. Cell Discovery, 3:17036.
  • Fu, X., Q. Yang, B. Wang, J. Zhao, M. Zhu, S. M. Parish, and M. Du. (2017). Reduced satellite cell density and myogenesis in Wagyu compared to Angus cattle as a possible explanation of its high marbling. Animal, 9: 1-8.
  • Wang, B., Z. Wang, J. M. de Avila, M. J. Zhu, F. Zhang, N. A. Gomez, L. Zhao, Q. Tian, J. Zhao, J. Maricelli, H. Zhang, B. D. Rodgers,andM. Du. (2017). Moderate alcohol intake induces thermogenic brown/beige adipocyte formation via elevating retinoic acid signaling. FASEB Journal, 31: 4612-4622.
  • Wang, B., X. Fu, M.J. Zhu, and M. Du. (2017). Retinoic acid inhibits white adipogenesis by disrupting GADD45A mediated Zfp423 DNA demethylation. Journal of Molecular Cell Biology, 9: 338-349.
  • Zhao, J., Q. Yang, L. Zhang, X. Liang, X. Sun, B. Wang, Y. Chen, M. J. Zhu, and M. Du. (2017). AMPKa1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development. Biochemical and Biophysical Research Communications, 491: 508-514.
  • Du, M., S.P. Ford, and M. J. Zhu. (2017). Optimizing livestock production efficiency through maternal nutritional management and fetal developmental programming. Animal Frontiers, 7: 5-11.
  • Wang, S., X. Liang, Q. Yang, X. Fu, M. Zhu, B.D. Rodgers, Q. Jiang, M. V. Dodson, and M. Du. (2017). Resveratrol enhances brown adipocyte formation and function by activating AMP-activated protein kinase (AMPK) a1 in mice fed high-fat diet. Molecular Nutrition and Food Research, 61: 1600746.
  • Wang B., X. Fu, X. Liang, Z. Wang, Q. Yang, T. Zou, W. Nie, J. Zhao, P. Gao, M. J. Zhu, J. M. De Avila, J. Maricelli, B. D. Rodgers, and M. Du. (2017). Maternal retinoids increase PDGFRa progenitor population and beige adipogenesis in progeny by stimulating vascular development. EBioMedicine, 18:288-299.
  • Griner, J. D., C. J. Rogers, M. J. Zhu, and M. Du. (2017). Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling. Adipocyte, 6: 12-19.
  • Zou, T., Q. Yang, B. Wang, M. Zhu, P. W. Nathanielsz, and M. Du. (2017). Resveratrol supplementation to high fat diet-fed pregnant mice promotes brown and beige adipocyte development and prevents obesity in male offspring. Journal of Physiology, 595: 1547-1562.
  • This is an Editor’s choice article and was further highlighted by a Translational Perspective: Aiken C. E., and S. E. Ozanne, Breaking the cycle of intergenerational obesity, Journal of Physiology 595: 1443-1444.
  • Liang, X. W., Q. Y. Yang, L. P. Zhang, J. Maricelli, B. D. Rodgers, M. J. Zhu, and M. Du (2016). Maternal high-fat diet during lactation impairs thermogenic function of brown adipose tissue in offspring mice. Scientific Reports, 6: 34345.
  • Yang, Q., X. Liang, X. Sun, L. Zhang, X. Fu, C. J. Rogers, A. Berim, S. Zhang, S. Wang, B. Wang, M. Foretz, B. Viollet, D. R. Gang, B. D. Rodgers, M. Zhu, and M. Du. (2016). AMPK/α-ketoglutarate axis dynamically mediates DNA demethylation in the Prdm16 promoter and brown adipogenesis. Cell Metabolism, 24: 542-554.
  • Wang, B., Q. Yang, C. L. Harris, M. L. Nelson, J. R. Busboom, M. J. Zhu, and M. Du. (2016). Nutrigenomic regulation of adipose tissue development – role of retinoic acid. Meat Science, 120: 100-106.
  • Liang, X., Q. Yang, X. Fu, C. J. Rogers, B. Wang, H. Pan, M. J. Zhu, P. W. Nathanielsz, and M. Du. (2016). Maternal obesity epigenetically alters visceral fat progenitor cell properties in male offspring mice. Journal of Physiology, 594: 4453-4466.
  • Miao, Z. G., L. P. Zhang, X. Fu, Q. Y. Yang, M. J. Zhu, M. V. Dodson, and M. Du. (2016). Invited review: Mesenchymal progenitor cells in intramuscular connective tissue development. Animal, 10: 75-81.
  • Fu, X., M. J. Zhu, S. Zhang, F. Marc, V. Benoit, and M. Du. (2016). Obesity impairs skeletal muscle regeneration via inhibition of AMP-activated protein kinase. Diabetes. 65: 188-200.
  • Fu, X., M. J. Zhu, M. V. Dodson, and M. Du. (2015). AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration.Journal of Biological Chemistry. 290: 26445-26456.
  • Du, M., W. Bo, M.J. Zhu. (2015). Fetal programming in meat production. Meat Science, 109: 40-47. [1] 

杜敏撰寫著作

· Du, M., and M. V. Dodson. (2011). Advanced techniques to enhance marbling in meat. In “Control of Meat Quality”. pp 105-115, Edited by S. T. Joo.Transworld Research Network. [8] 
· Du, M., and R. J. McCormick. (2009).Applied Muscle Biology and Meat Science. CRC press, Boca Raton, FL. [9] 
· Du, M., and Meijun Zhu. (2009). Fetal programming of skeletal muscle development. In “Applied Muscle Biology and Meat Science”. Edited by M. Du and R. J. McCormick. CRC press, Boca Raton, FL. [9] 
· Du, M., Q. W. Shen, K. R. Underwood, J. F. Tong, and M. J. Zhu. (2009). AMP-activated protein kinase in muscle growth, fat deposition and meat quality. In “Applied Muscle Biology and Meat Science”. Edited by M. Du and R. J. McCormick. CRC press, Boca Raton, FL.
· Du, M., and M. J. Zhu. (2008). Developmental programming of fetal skeletal muscle by maternal nutrition. In “Developmental Programming of Diabetes and Metabolic Syndrome”, Page 85-102. Edited by Marlon E. Cerf. Transworld Research Network. [10] 

杜敏聯繫方式

Veterinary and Biomedical Research Building (VBR) 155 [1] 
Department of Animal Sciences
Washington State University, Pullman, WA 99164 [1] 
參考資料