杜嘉木

09/1999 - 06/2003復旦大學生命科學學院，理學學士

09/2003 - 06/2008中科院上海生命科學研究院生物化學與細胞生物學研究所，理學博士

07/2008 - 09/2009中科院上海生科院生物化學與細胞生物學研究所，助理研究員

10/2009 - 06/2013紀念斯隆-凱特琳癌症中心，博士後

07/2013 - 08/2014紀念斯隆-凱特琳癌症中心，助理研究員

09/2014-至今 中國科學院上海植物逆境生物學研究中心，研究員 ^[1] 

(27) Du J#, Patel DJ#. Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks. Biochim Biophys Acta (Gene Regulatory Mechanisms). 2014; 1839:719-27. (# co-corresponding authors)

(26) Le Thomas A, Stuwe E, Li S, Du J, Marinov G, Rozhkov N, Chen YC, Luo Y, Sachidanandam R, Toth KF, Patel D, Aravin AA. Transgenerationally inherited piRNAs trigger piRNA biogenesis by changing the chromatin of piRNA clusters and inducing precursor processing. Genes Dev. 2014; 28: 1667-80

(25) Du J*, Johnson LM*, Groth M, Feng S, Hale CJ, Li S, Vashisht AA, Gallego-Bartolome J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol Cell. 2014; 55, 495–504. (* co-first authors)

(24) Zhong X*, Du J*, Hale CJ, Gallego-Bartolome J, Feng S, Vashisht AA, Chory J, Wohlschlegel JA, Patel DJ, Jacobsen SE. Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases. Cell. 2014; 157: 1050-60. (* co-first authors)

(23) Johnson LM*, Du J*, Hale CJ, Bischof S, Feng S, Chodavarapu RK, Zhong X, Marson G, Pellegrini M, Segal DJ, Patel DJ, Jacobsen SE. SRA- and SET-domain-containing proteins link RNA polymerase V occupancy to DNA methylation. Nature. 2014; 507: 124-8. (* co-first authors)

(22) Stroud H, Do T, Du J, Zhong X, Feng S, Johnson L, Patel DJ, Jacobsen SE. Non-CG methylation patterns shape the epigenetic landscape in Arabidopsis. Nat Struct Mol Biol. 2014; 21: 64-72.

(21) Law JA*, Du J*, Hale CJ*, Feng S, Krajewski K, Palanca AM, Strahl BD, Patel DJ, Jacobsen SE. Polymerase-IV occupancy at RNA-directed DNA methylation sites requires SHH1. Nature. 2013; 498: 385-89. (* co-first authors)

(20) Li S, Du J, Yang H, Yin J, Ding J, Zhong J. Functional and structural characterization of DNMT2 from Spodoptera frugiperda. J Mol Cell Biol. 2013; 5: 64-66.

(19) Du J*, Zhong X*, Bernatavichute YV, Stroud H, Feng S, Caro E, Vashisht AA, Terragni J, Chin HG, Tu A, Hetzel J, Wohlschlegel JA, Pradhan S, Patel DJ, Jacobsen SE. Dual binding of chromomethylase domains to H3K9me2-containing nucleosomes directs DNA methylation in plants. Cell. 2012; 151:167-80. (* co-first authors)

(18) Du J, Kelly AE, Funabiki H, Patel DJ. Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 2012 ;20:185-95.

(17) Wang S, Du J, Tang H, Ding X, Zha M, Xu Z. Expression, purification, crystallization, and preliminary X-ray diffraction analysis of the human TLE1 Q domain. Acta Biochim Biophys Sin. 2011; 43:149-53.

(16) Yang H, Wang J, Du J, Zhong C, Zhang D, Guo H, Guo Y, Ding J. Structural basis of immunosuppression by the therapeutic antibody daclizumab. Cell Res. 2010; 20:1361-71.

(15) Du J, Yang H, Zhang D, Wang J, Guo H, Peng B, Guo Y, Ding J. Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab. J Immunol. 2010; 184:1361-8.

(14) Li Y, Du J, Zhang P, Ding J. Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site. J Struct Biol. 2010; 169:399-405.

(13) Du J*, Yang H*, Peng B, Ding J. Structural modeling and biochemical studies reveal insights into the molecular basis of the recognition of beta-2-microglobulin by antibody BBM.1. J Mol Recognit. 2009; 22:465-73. (* co-first authors)

(12) Chen J, Zhang L, Zhang Y, Zhang H, Du J, Ding J, Guo Y, Jiang H, Shen X. Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization. BMC Microbiol. 2009; 9:91

(11) Du J, Yang H, Guo Y, Ding J. Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol Immunol. 2009; 46:2419-23.

(10) Weng L, Du J, Zhou J, Ding J, Wakita T, Kohara M, Toyoda T. Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain. Arch Virol. 2009; 154:765-73.

(9) Du J*, Hou S*, Zhong C*, Lai Z, Yang H, Dai J, Zhang D, Wang H, Guo Y, Ding J. Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis. J Mol Biol. 2008; 382:835-842. (* co-first authors)

(8) Yu XL*, Hu T*, Du J*, Ding JP*, Yang XM, Zhang J, Yang B, Shen X, Zhang Z, Zhong WD, Wen N, Jiang H, Zhu P, Chen ZN. Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem. 2008; 283:18056-65. (* co-first authors)

(7) Du J*, Wang H*, Zhong C, Peng B, Zhang M, Li B, Hou S, Guo Y, Ding J. Crystal structure of chimeric antibody C2H7 Fab in complex with a CD20 peptide. Mol Immunol. 2008; 45:2861-8. (* co-first authors)

(6) Wu D, Zhang L, Kong Y, Du J, Chen S, Chen J, Ding J, Jiang H, Shen X. Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori. Proteins. 2008; 72:1148-60.

(5) Wu D, Hu T, Zhang L, Chen J, Du J, Ding J, Jiang H, Shen X. Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis. Protein Sci. 2008; 17:1066-76.

(4) Du J, Wang H, Zhong C, Peng B, Zhang M, Li B, Hou S, Guo Y, Ding J. Structural basis for recognition of CD20 by therapeutic antibody Rituximab. J Biol Chem. 2007; 282:15073-80.

(3) Zhang P*, Du J*, Sun B, Dong X, Xu G, Zhou J, Huang Q, Liu Q, Hao Q, Ding J. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res. 2006; 34:6621-8. (* co-first authors)

(2) Zhang P, Zhao J, Wang B, Du J, Lu Y, Chen J, Ding J. The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14. Protein Sci. 2006; 15:2423-34.

(1) Zheng X, Li Z, Du J, Tang S, Bai C. Analysis of oligosaccharides by high performance liquid chromatography. Chinese J Anal Chem. 2005; 33:291-5 ^[1]