李大鵬

2005-2010年本科就讀於南京農業大學動物醫學院，獲學士學位。

2010-2016年博士就讀於中國科學院上海巴斯德研究所，獲博士學位。

2017年加入杜克大學醫學院人類疫苗研究所從事博士後研究工作，隨後任杜克大學醫學院講師。

2022年夏季將全職加入西湖大學應急醫學研究中心、生命科學學院。

李大鵬博士長期從事針對新發傳染病的疫苗和抗體的研究，領域涉及冠狀病毒、HIV、丙型肝炎病毒、埃博拉病毒等。代表工作包括：1) 新冠病毒與相關冠狀病毒的抗體研究及疫苗開發；2) 丙型肝炎病毒和埃博拉病毒的疫苗開發與評價體系的建立；3) 對HIV感染者體內廣譜中和抗體相關轉錄因子和免疫特徵的鑑定；4) 針對NK細胞的免疫檢查點抗體的開發與應用。

實驗室將利用分子生物學、病毒學和免疫學的方法，結合系統生物學（抗體組學、轉錄組學等）與結構生物學，針對冠狀病毒、黃病毒、新型布尼亞病毒等新發傳染病和人畜共患傳染病的病原，在以下幾個方向進行研究：1) 新型疫苗（納米顆粒疫苗、病毒載體疫苗、mRNA疫苗等）的設計開發及評價；2) 治療性人源抗體的分離鑑定及基於結構的優化；3) 疫苗與抗體免疫保護機制的研究；4) 針對宿主因子或免疫檢查點的新型免疫治療策略的開發。 ^[1] 

1. Dapeng Li, David R Martinez, Alexandra Schäfer, Haiyan Chen, ..., Kevin O Saunders#, Barton F Haynes#. Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine. Nature Communications. 2022. 13, 6309.

2. Dapeng Li*, Robert J. Edwards*, Kartik Manne*, David R. Martinez*, Alexandra Schäfer*, ..., Barton F. Haynes#, Kevin O. Saunders#. In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies. Cell. 2021. 184(16):4203-4219.e32.

3. David R. Martinez*#, Alexandra Schaefer*, Sophie Gobeil*, Dapeng Li*, …, Priyamvada Acharya#, Barton F. Haynes#, Ralph S. Baric#. A broadly cross-reactive and neutralizing antibody protects against Sarbecovirus challenge in mice. Science Translational Medicine. 2022. 14, eabj7125.

4. Dapeng Li*, Simon Brackenridge*, Lucy C Walters*, …, Geraldine M. Gillespie#, Andrew J. McMichael#, Barton F. Haynes#. Mouse and Human Antibodies that Bind HLA-E-Leader Peptide Complexes and Enhance NK Cell Cytotoxicity. Communications Biology, 2022. 5, 271.

5. Dapeng Li, Gregory D. Sempowski, Kevin O. Saunders, Priyamvada Acharya, Barton F. Haynes#. SARS-CoV-2 Neutralizing Antibodies for COVID-19 Prevention and Treatment. Annual Review of Medicine. 2022. 73:1-16.

6. Dapeng Li*#, Todd Bradley*, Derek W. Cain*, …, Barton F. Haynes#. RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures. ImmunoHorizons. 2020. 4(11):713-728.

7. Todd Bradley*#, Dimitra Peppa*, Isabela Pedroza-Pacheco*, Dapeng Li*, …, Persephone Borrow#, Barton F. Haynes#. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018. 175(2):387-399.e17.

8. Tan Chen*, Dapeng Li*, Yufeng Song*, Xi Yang, Qingwei Liu, Xia Jin, Dongming Zhou#, Zhong Huang#. A heterologous prime-boost Ebola virus vaccine regimen induces durable neutralizing antibody response and prevents Ebola virus-like particle entry in mice. Antiviral Research. 2017. 145:54-59.

9. Dapeng Li, Xuesong Wang, Markus von Schaewen, Wanyin Tao, Yunfang Zhang, Brigitte Heller, Gabriela Hrebikova, Qiang Sun, Qiang Deng, Alexander Ploss#, Jin Zhong#, Zhong Huang#. Immunization with a subunit hepatitis C virus vaccine elicits pan-genotypic neutralizing antibodies and intra-hepatic T-cell responses in non-human primates. The Journal of Infectious Diseases. 2017. 215(12):1824-1831.

10. Dapeng Li, Markus von Schaewen, Xuesong Wang, Wanyin Tao, Yunfang Zhang, Li Li, Brigitte Heller, Gabriela Hrebikova, Qiang Deng, Alexander Ploss#, Jin Zhong#, Zhong Huang#. Altered glycosylation patterns increase immunogenicity of a subunit HCV vaccine, inducing neutralizing antibodies which confer protection in mice. Journal of Virology. 2016. 90(23):10486-10498.

11. Dapeng Li*, Tan Chen*, Yang Hu, Qingwei Liu, Dongming Zhou, Xia Jin, Zhong Huang. A novel reporter Ebola virus-like particle enabling in vivo infection and bioluminescent imaging of mice under non BSL-4 conditions. Journal of Virology. 2016. 90(19):8720-8.

12. Dapeng Li, Zhong Huang, Jin Zhong. Hepatitis C virus vaccine development: old challenges and new opportunities. National Science Review. 2015. 2:285–295. ^[1]