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朱興奮

鎖定
朱興奮，男，1982年，朱興奮在英國帝國理工學院獲生物化學本科學位，3年後獲博士學位， 1987-1993年期間在美國哈佛大學任講師。
中文名
朱興奮
外文名
TooHeng-phon [1] 
國    籍
馬來西亞 [1] 
畢業院校
英國帝國理工學院 [1] 
性    別
男
職    稱
教授

目錄

  1. 1 所獲專利
  2. 2 人物履歷

朱興奮所獲專利

朱興奮
朱興奮(5張)
用於診斷胃癌的miRNA生物標誌物 [2-3] 
用於慢性心力衰竭的診斷和預後的方法 [4] 
通過檢測微小RNA(miRNA)的表達水平來確定患乳腺癌的風險的方法 [4] 
Affiliations
Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, NUS
Adjunct Scientist, Bioprocess Technology Institute, A*STAR
Advisor, Biotransformation Innovation Platform, A*STAR
Founder, MiRXES Pte LTD [5] 
Education
Degree and Institution [5] 
Year(s)
B.Sc, ARCS. in Biochemistry, Imperial College of Science & Technology, UK [5] 
1982
PhD, Imperial College & Institute of Ophthalmology, London, UK [5] 
1985
Professional Experience
HP Too received his undergraduate training in Biochemistry, Imperial College of Science & Technology, UK. He then continued with his PhD training in a joint research project in Imperial College, Institute of Ophthalmology and West Minister Hospital, London. Thereafter, he received further training in the Medical Research Council, Cambridge (UK), where he was a Procter & Gamble Fellow. He then moved to the Department of Anesthesiology and Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School where he was a recipient of the Merck Sharpe Dohme Academic Development Fellowship. Currently, he is a faculty in the Department of Biochemistry, National University Singapore, a Principal Scientist in the Bioprocess Technological Institute and was a Fellow of the Singapore Massachusetts Institute of Technology Alliance (Molecular Engineering of Biological & Chemical Systems program; Chemical & Pharmaceutical Engineering program). His laboratory was funded by Roche Diagnostics (USA & Asia Pacific) and National Institute of Health (USA) to develop qPCR assays for infectious diseases. He is an awardee of a number of Commercialization of Technology grants from A*STAR and Singapore-Massachusetts Research & Technology (SMART). He has intellectual property protections on specific diagnostic platforms with various departments and with Massachusetts Institute of Technology, USA. He is collaborating with a number of clinical groups locally and globally on discovery and development of microRNA biomarkers. [5] 

朱興奮人物履歷

在英國帝國理工學院獲生物化學本科學位，3年後獲博士學位。 [1-2] 
曾在英國劍橋大學從事博士後研究工作 [1-2] 
2002年，朱興奮在新加坡國立大學建立了東南亞第一家QPCR（實時定量基因擴增熒光檢測系統）核酸檢測實驗室。 [6] 
2010年，新加坡科技研究局立項成立miRNA臨牀標誌物研發中心，朱興奮擔任主任。 [1] 
2014年，朱興奮和鄒瑞陽等在新加坡共同創建了MiRXES公司，任首席科學顧問。 [1] 
Research Interest
Bioanalytics (qPCR, bionanotechnology), MicroRNA, GDNF, Metabolic Engineering of Isoprenoids, Gene Delivery, Stem Cells. [5] 
Selected Publications
  1. Zhang C, Seow VY, Chen X,Too HP. Multidimensional heuristic process for high-yield production of astaxanthin and fragrance molecules in Escherichia coli. Nat Commun. 9(1):1858 (2018). [5] 
  2. Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC,Too HP, Soong R, Wenk MR, Little P, Teo YY. Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study. Nat Commun. 8(1):653 (2017). [5] 
  3. Neo SH, Chung KY, Quek JM,Too HP. Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paper-based matrix. Sci Rep. 7(1):16686 (2017) [5] 
  4. Y.K. Ho, L.H. Zhou, K.C. Tam,H.P. Too. Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase. Nucleic Acids Res. 45(6):e38 (2017). [5] 
  5. Chen X, Zhang C, Zou R, Stephanopoulos G,Too HP. In Vitro Metabolic Engineering of Amorpha-4,11-diene Biosynthesis at Enhanced Rate and Specific Yield of Production. ACS Synth Biol. 6:1691-1700 (2017). [5] 
  6. S. Wu, Y. Zhou, T. Wang,H.P. Too, D. I. C. Wang, Z. Li. Highly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysis. Nat Commun. (2016) 7:11917. Cheng H, Zhou L, Li B, Zhu M, Too HP, Choi WK. Nano-topology guided neurite outgrowth in PC12 cells is mediated by miRNAs. Nanomedicine. 2014. 10(8):1871-5. [5] 
  7. Ajikumar PK, Xiao WH, Tyo KE, Wang Y, Simeon F, Leonard E, Mucha O,Too HP, Pfeifer B, Stephanopoulos G. Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science (2010) 330 (6000):70-4 [5] 
  8. Wan G, Lim QE,Too HP. High-performance quantification of mature microRNAs by real-time RT-PCR using deoxyuridine-incorporated oligonucleotides and hemi-nested primers. RNA (2010) 16(7):1436-45 [5] 
參考資料