曹麗娟

內源性物質代謝調控與免疫調節機制研究：側重於研究內源性活性物質膽汁酸、短鏈脂肪酸、脂質等代謝調控機理，重點關注腸道菌羣代謝及其在免疫系統中的功能與生理/病理學意義。在此基礎上，研究內源性活性代謝物在腸道、心血管、感染性休克等疾病中參與免疫調控的分子機制。

天然藥物代謝處置與免疫調控機制研究：側重於研究生脈方、清腸化濕方等具有臨牀療效的中藥方用於治療心血管、腸炎等疾病的物質基礎與藥效機制，結合基礎研究與臨牀研究，從腸道菌代謝與免疫調控的角度，探索天然藥物發揮免疫調節的分子機制 ^[1]  。

1.Hao H#, Cao L# (co-first author), Jiang C#, Che Y, Zhang S, Takahashi S, Wang G*, Gonzalez FJ*. Farnesoid X Receptor Regulation of the NLRP3 Inflammasome Underlies Cholestasis-Associated Sepsis. Cell Metab. 2017 Apr 4;25(4):856-867.e5. (IF 20.565)

2.Zhou X#, Cao L# (co-first author), Jiang C#, Xie Y, Chen X, Krausz KW, Qi Y, Sun L, Shah YM, Gonzalez FJ, Wang G*, Hao H*. PPARα-UGT axis activation represses intestinal FXR-FGF15 feedback signalling and exacerbates experimental colitis. Nat Commun. 2014 Sep 3;5:4573. (IF 12.353)

3.Li Q#, Cao L#（co-first author）, Tian Y, Zhang P, Ding C, Lu W, Jia C, Shao C, Liu W, Wang D, Ye H*, Hao H*. Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming. Mol Cell Proteomics. 2018 Aug;17(8):1531-1545. (IF 5.232)

4.Cao LJ#*, Che Y#, Meng T, Deng SS, Zhang J, Zhao M, Xu WF, Wang DD, Pu ZC, Wang GJ, Hao HP*. Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis associated colon cancer. Oncotarget. 2017, 8 (38):63665-63679. (IF 5.168)

5.Li Q, Ding C, Meng T, Lu W, Liu W, Hao H*, Cao L*. Butyrate suppresses motility of colorectal cancer cells via deactivating Akt/ERK signaling in histone deacetylase dependent manner. J Pharm Sci. 2017, Accept. Doi: 10.1016/j.jphs.2017.11.004. (IF 2.575)

6.Zhao M#, Xu WF#, Shen HY, Shen PQ, Zhang J, Wang DD, Xu H, Wang H, Yan TT, Wang L, Hao HP, Wang GJ*, Cao LJ*. Comparison of bioactive components and pharmacological activities of ophiopogon japonicas extracts from different geographical origins. J Pharm Biomed Anal. 2017, 138: 134-141. (IF 2.831) ^[1] 

1、“代謝信號分子調控與藥物靶標發現”獲得江蘇省科學技術一等獎（排名第三） ^[2]