曹瑩

2000年，清華大學生物科學與技術系，本科畢業。

2005年，清華大學生物科學與技術系細胞與發育專業，博士畢業。

博士期間，主要研究FGF信號通路在斑馬魚早期胚胎髮育中的作用。

2005年至2010年，耶魯大學醫學院遺傳系從事博士後研究，主要研究多囊腎的分子機制。

2010年9月起，任同濟大學生命科學與技術學院教授，博導。 ^[1] 

遺傳與發育

1、纖毛相關新因子的鑑定和功能研究

2、腎臟發育與腎臟疾病的機制研究

3、其他人類罕見病/纖毛類疾病的機制研究

4、腎臟幹細胞的研究

^[1] 

通過以斑馬魚多囊腎為模型進行化學小分子的篩選，找到了一個跟表觀遺傳修飾相關的小分子VPA可以特異的抑制多囊腎的形成，並且在小鼠多囊腎模型中也有相同的效果，表明表觀遺傳修飾在多囊腎的形成中有重要作用，但是其機理不是很清楚。

綜上，主要以斑馬魚為模型，從細胞極性和表觀遺傳變化兩方面入手，研究多囊腎的疾病機制，同時，用斑馬魚的多囊腎模型進行中草藥的篩選。 ^[1] 

1.Ruikun Hu, Weilai Huang, Miaomiao Jin, Jiangfang Liu, Yue Wu, Jingyu Li, Zehao Yu, Hong Wang, andYing Cao.Mutagenesis of ciliary candidate genes with CRISPR/Cas9 system in zebrafish identifies genes required for retina development. FASEB J. 2019

2.Wenyan Xu, Miaomiao Jin, Weilai Huang, Ruikun Hu, Hong Wang, Jingyu Li and Ying Cao. Apical PtdIns(4,5)P2 is required for ciliogenesis and suppression of polycystic kidney disease. FASEB J. 2019

3.R. Sun, Y. Wang, M. Jin, L. Chen1, Y. Cao*, and F. Chen*. Identification and Functional Studies of MYO1H for Mandibular Prognathism. Journal of Dental Research, 2018: 1–9 (*共通訊)

4.Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, Yu Y, Tang J, Flockerzi V,Cao Y, Cao E, Chen XZ. Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun. 2018 Jun 13;9(1):2302.

5.Xu D, Lv J, He L, Fu L, Hu R, Cao Y*, Mei C*. Scribble influences cyst formation in autosomal-dominant polycystic kidney disease by regulating Hippo signaling pathway. FASEB J. 2018 Mar. (*共通訊)

6.Yunru Chen, Shiyang Zeng, Ruikun Hu, Weilai Huang, Xiangxiu Wang, Jiangfang Liu, Luying Wang, Guifen Liu, Ying Cao* and Yong Zhang*. Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish. PLoS One，2017 Aug 11，12(8):e0182528. (*共通訊)

7.Wenyan Xu, Miaomiao Jin, Ruikun Hu, Hong Wang, Fan Zhang, Shiaulou Yuan andYing Cao. The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology, 2017 Jan;28(1):118-129. (highlighted in Nature Reviews Nephrology, 2016,12: 508)

8.Cao, Y., Park, A. and Sun, Z. (2010). Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity. J Am Soc Nephrol. 21(8):1326-33. (cover story)

9.Cao, Y., Semanchik N., Lee SH., Somlo S., Barbano PE., Coifman R., Sun Z. (2009). Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. PNAS, 106(51):21819-21824

10.Rui, Y.*, Xu, Z.*, Xiong, B.*, Cao, Y.*, Lin, S., Zhang, M., Chan, SC., Luo, W., Han, Y., Lu, Z., Ye, Z., Zhou, HM., Han, J., Meng, A., and Lin, SC. (2007). A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell, 13(2):268-82. (*authors contribute equally)

11.Cao, Y., Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A. (2004). fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev Biol, 271:130-143. ^[1]