曹毅

南京大學物理學院教授， 2010.5至今

2009-2010加拿大不列顛哥倫比亞大學化學系博士後。 ^[2] 

加拿大不列顛哥倫比亞大學，化學系，博士（導師：Hongbin Li教授），2004.9-2009.4

南京大學，化學化工學院，碩士（導師：蔣錫羣教授），2001.9-2004.6

南京大學，化學化工學院，本科 （導師：全一武、陳慶民教授），1997.9-2001.6 ^[1] 

物理生物學新生研討課;

物理生物學前沿 ^[2] 

主要的研究領域包括：單分子生物物理、蛋白質多肽生物材料、生物力學。本實驗室主要發展和應用多種單分子測量手段，如原子力顯微鏡，磁鑷，全內反射熒光顯微鏡等來探索生物分子結構與功能之間的關係，特別是環境因素對生物分子結構與功能的調控。我們還通過自組裝的方法，設計製備有着多種新奇物理和生物特性的蛋白質多肽生物材料，用於納米技術和組織工程。 ^[2] 

國家自然科學基金面上項目：彈性蛋白力學構造的單分子研究 （2011-2013）；蛋白質摺疊的單分子力譜研究（2012-2014）；新世紀人才支持計劃（2011-2013） ^[1] 

1. “How Do Proteins Unfold upon Adsorption on Nanoparticle Surfaces?” Pan, H, Qin, M, Meng, W, Cao, Y*, Wang, W* (2012) Langmuir. [Epub ahead of print]

2. “A versatile "multiple fishhooks" approach for the study of ligand-receptor interactions using single molecule atomic force microscopy.” Han, X, Qin, M, Pan, H, Cao, Y*, Wang, W* (2012) Langmuir 28:10020-5.

3. “Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force” Gao X, Qin, M, Yin, PG, Liang, JY, Wang, J, Cao, Y*, Wang, W* (2012) Biophysical Journal 102:2149-57.

4. “Low folding cooperativity of Hp35 revealed by single-molecule force spectroscopy and molecular dynamics simulation” Lv, CM, Tan, C, Qin, M., Zou, DW, Cao, Y*, Wang, W* (2012) Biophysical Journal 102:1944-51.

5. “A genetically encoded copper(I) sensor based on engineered structural distortion of EGFP.” Liang, J, Qin, M, Xu, R, Gao, X, Shen, Y, Xu, Q, Cao, Y*, Wang, W* (2012) Chemical Communications 48:3890-2

6. “Designed biomaterials to mimic the mechanical properties of muscles” Lv, S, Dudek, DM, Cao, Y, Balamurali, MM, Gosline, J, Li, HB (2010) Nature 465: 69-73

7. “Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins” Cao, Y, Yoo, T, Li, HB (2008) Proceedings of the National Academy of Sciences USA 105: 11152-11157.

8. “Engineered elastomeric proteins with dual elasticity can be controlled by a molecular regulator” Cao, Y, Li, HB (2008) Nature Nanotechnology 3: 512-516.

9. “A functional single-molecule binding assay via force spectroscopy” Cao, Y, Balamurali, MM, Sharma, D, Li, HB (2007) Proceedings of the National Academy of Sciences USA 104:15677-15681.

10.“Polyprotein of GB1 is an ideal artificial elastomeric protein” Cao, Y, Li, HB (2007) Nature Materials6: 109-114. ^[1]