方志友

教育經歷:

中國科學技術大學細胞生物學博士；安徽農業大學本科與分子生物學碩士

科研與學術工作經歷:

中國科學院合肥物質科學研究院健康與醫學技術研究所；中國科學院合肥物質科學研究院醫學物理與技術中心，研究員

美國麻州大學醫學院細胞與發育生物學系，博士後/研究助理

安徽農業大學生命科學學院，講師

已在Plos Biol., Cancer Res.,Theranostics, Circulation，J Bio Chem., J Pineal Res., J Exp Clin Cancer Res., Mol. Cell Proteomics, Traffic, Front Oncol.,Cancer Lett.,J Cell Sci.,Mol Biol Cell 等國際SCI雜誌上發表論文三十多篇。承擔國家自然科學基金面上項目，安徽省自然科學基金面上項目和財政部修購專項基金研究課題等。 ^[1] 

主要研究方向包括：腦部腫瘤（膠質瘤）發生、發展的分子病因；細胞運動與腫瘤侵襲轉移動力學特徵；蛋白質翻譯後修飾調控腫瘤幹細胞與復發、耐藥相關性；腫瘤微環境（缺氧）在腫瘤發展過程中的作用等。

1. He Jiajia, Liu Ke, Wu Yifan, ZhaoChenhui, Yan Shuaijie, Chen Jia-Hui, Hu Lizhu, Wang Dongmei, Zheng Fan, Wei Wenfan,Xu Chao, Huang Chengdong, Liu Xing, Yao Xuebiao, Ding Lijun, Fang Zhiyou*, TangAi-Hui*, Fu Chuanhai*. The AAA-ATPase Yta4/ATAD1 interacts with themitochondrial divisome to inhibit mitochondrial fission. PLoS Biol. 2023 Aug 17,21(8):e3002247.

2. Chen Zhigang, Tian Dasheng,Chen Xueran, Cheng Meng, Xie Han, Zhao Jiajia, Liu Jun, Fang Zhiyou*, ZhaoBing*, Bian Erbao*. Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7promotes glioma progression. Cell Death Dis. 2023 Jun 29,14(6):383.

3. Chen Xueran*, Niu Wangxiang,Fan Xiaoqing, Yang Haoran, Zhao Chenggang, Fan Junqi, Yao Xuebiao*, Fang Zhiyou*.Oct4A palmitoylation modulates tumorigenicity and stemness in humanglioblastoma cells. Neuro Oncol. 2023 Jan 5,25(1):82-96.

4. Zhao Chenggang, Yu Huihan, FanXiaoqing, Niu Wangxiang, Fan Junqi, Sun Suling, Gong Meiting, ZhaoBing*, Fang Zhiyou*, Chen Xueran*. GSK3-β palmitoylation mediated byZDHHC4 promotes tumorigenicity of glioblastoma stem cells intemozolomide-resistant glioblastoma through the EZH2-STAT3 axis. Oncogenesis.2022 May 23,11(1):28.

5. Fan Xiaoqing#, Sun Suling#,Yang Haoran, Ma Huihui, Zhao Chenggang, Niu Wangxiang, Fan Junqi, FangZhiyou, Chen Xueran*. SETD2 Palmitoylation Mediated by ZDHHC16 in EpidermalGrowth Factor Receptor-Mutated Glioblastoma Promotes Ionizing Radiation-InducedDNA Damage. Int J Radiat Oncol Biol Phys. 2022 Jul 1,113(3):648-660.

6. Fan Xiaoqing#, Fan Junqi#, YangHaoran, Zhao Chenggang, Niu Wangxiang, Fang Zhiyou*, Chen Xueran*.Heterogeneity of subsets in glioblastoma mediated by Smad3 palmitoylation.Oncogenesis. 2021 Oct 27,10(10):72.

7. Chen Xueran*, Hao Aijun, LiXian, Ye Kaiqin, Zhao Chenggang, Yang Haoran, Ma Huihui, Hu Lei, Zhao Zhiyang,Hu Lizhu, Ye Fang, Sun Qiuyan, Zhang Huaman, Wang Hongzhi, Yao Xuebiao, FangZhiyou*. Activation of JNK and p38 MAPK Mediated byZDHHC17 Drives GlioblastomaMultiforme Development and Malignant Progression. Theranostics,2020, 10(3):998-1015.

8. Chen Xueran*, Li Hao, FanXiaoqing, Zhao Chenggang, Ye Kaiqin, Zhao Zhiyang, Hu Lizhu, Ma Huihui, WangHongzhi, Fang Zhiyou*. Protein Palmitoylation Regulates Cell Survival byModulating XBP1 Activity in Glioblastoma Multiforme. Molecular Therapy-Oncolytics,2020, 17: 518-530.

9. Chen Xueran*, Fan Xiaoqing,Zhao Chenggang, Zhao Zhiyang, Hu Lizhu, Wang Delong, Wang Ruiting, Fang Zhiyou*.Molecular subtyping of glioblastoma based on immune-relatedgenes for prognosis.Scientific Reports, 2020, 10(1): 0-15495.

10. Zhao Chenggang, Zhao Zhiyang,Wang Zhen, Hu Lizhu, Wang Hongzhi, Fang Zhiyou*. Supervillin promotes tumorangiogenesis in liver cancer. Oncology Reports, 2020, 44(2):674-684.

11. Hu Lei, Chen Meng, Chen Xueran,Zhao Chenggang, Fang Zhiyou, Wang Hongzhi, Dai Haiming*. Chemotherapy-inducedpyroptosis is mediated byBAK/BAX-caspase-3-GSDME pathway and inhibited by2-bromopalmitate. Cell Death& Disease, 2020, 11(4).

12. Hu Lulu, Shen Dachuan, LiangDapeng, Shi Ji, Song Chunyan, Jiang Ke, Ren Menglin, Du Sha, Cheng Wei, MaJianmei, Li Shao, Bi Xiaolin, Barr Martin P., Fang Zhiyou, Xu Qing*, Li Wenbin*,Piao Haozhe*, Meng Songshu*. Thyroid receptor-interacting protein 13 and EGFRform a feedforward loop promoting glioblastoma growth. Cancer Letters,2020,493: 156-166.

13. Chen Xueran*, Zhao Chenggang,Guo Bing, Zhao Zhiyang, Wang Hongzhi, Fang Zhiyou*. Systematic Profiling ofAlternative mRNA Splicing Signature for Predicting Glioblastoma Prognosis.Frontiers in Oncology, 2019, 9: 0-928.

14. Chen Xueran*, Zhao Chenggang,Zhao Zhiyang, Wang Hongzhi, Fang Zhiyou*. Specific Glioma Prognostic SubtypeDistinctions Based on DNA Methylation Patterns. Frontiers in Genetics, 2019,10: 0-786.

15. Bian Erbao#, Chen Xueran#, Xu Yadi,Ji Xinghu, Cheng Meng, Wang Hongliang, Fang Zhiyou*, Zhao Bing*. A central rolefor MeCP2 in the epigenetic repression of miR-200cduringepithelial-to-mesenchymal transition of glioma. Journal of Experimental&Clinical Cancer Research, 2019, 38(1).

16. Ma Huihui, Zhao Chenggang, ZhaoZhiyang, Hu Lizhu, Ye Fang, Wang Hongzhi, Fang Zhiyou, Wu Yuejin*, ChenXueran*. Specific glioblastoma multiforme prognostic-subtype distinctions basedon DNA methylation patterns. Cancer Gene Therapy, 2019.

17. Chen Xueran*, Hu Lei, YangHaoran, Ma Huihui, Ye Kaiqin, Zhao Chenggang, Zhao Zhiyang, Dai Haiming, WangHongzhi, Fang Zhiyou*. DHHC protein family targets different subsets of gliomastem cells in specific niches. Journal of Experimental & Clinical CancerResearch, 2019, 38(1): 0-25.

18. Chen Xueran, Zhang Shangrong,Wang Zhen, Wang Fengsong, Cao Xinwang, Wu Quan, Zhao Chenggang, Ma Huihui, YeFang, Wang Hongzhi, Fang Zhiyou*. Supervillin promotes epithelial-mesenchymaltransition and metastasis of hepatocellular carcinoma in hypoxia via activationof the RhoA/ROCK-ERK/p38 pathway. Journal of Experimental & Clinical CancerResearch, 2018, 37(1): 0-128.

19. Chen Xueran*, Wang Zhen, MaHuihui, Zhang Shangrong, Yang Haoran, Wang Hongzhi, Fang Zhiyou*. Melatoninattenuates hypoxia-induced epithelial-mesenchymal transition and cellaggressive viaSmad7/CCL20 in glioma. Oncotarget,2017,

20. Chen Xueran*, Ma Huihui, WangZhen, Zhang Shangrong, Yang Haoran, Fang Zhiyou*. EZH2 palmitoylation mediatedby ZDHHC5 in p53mutant glioma drives malignant development and progression.Cancer Res. 2017 Aug 3. pii: canres.1139.2017.

21. Chen Xueran, Yang Haoran, ZhangShangron, Wang Zhen, Ye Fang, Liang Chaozhao, Wang Hongzhi, Fang Zhiyou*.Anovel splice variant of supervillin, SV5, promotes carcinoma cell proliferationand cell migration. Biochem Biophys Res Commun.2017,482(1):43-49.

22. Chen Xueran*, Hao Aijun, LiXian, Du Zhaoxia, Li Hao, Wang Hongzhi, Yang Haoran, Fang Zhiyou*. Melatonininhibits tumorigenicity of glioblastomastem-like cells via the AKT-EZH2-STAT3signaling axis. J Pineal Res. 2016,61(2):208-217.

23. Chen Xueran, Li Hao, WangHongzhi, Yang Haoran, Ye Fang, Liang Chaozhao, Fang Zhiyou*.Preparation andAffinity-Purification of Supervillin Isoform 4 (SV4) Specific PolyclonalAntibodies. Protein J. 2016, 35(2):107-114.

24. Fang Zhiyou*, LunaElizabeth J*.Supervillin-mediated suppression of p53 protein enhances cell survival. Journalof Biological Chemistry. 2013.3.15, 288(11):7918-7929.

25. Fang Zhiyou , Takizawa Norio,Wilson Korey A, Smith Tara C, Delprato Anna, Davidson Michael W, LambrightDavid G, Luna Elizabeth J*. The membrane-associated protein, supervillin,accelerates F-actin-dependent rapid integrin recycling and cell motility.Traffic, 2010.6.01, 11(6) : 782-799.

26. Fang Zhiyou, Miao Yong, DingXia, Deng Hui, Liu Siqi, Wang Fengsong, Zhou Rihong, Watson Charles, FuChuanhai, Hu Qicong, Lillard James WJr, Powell Michael, Chen Yong, Forte JohnG, Yao Xuebiao*. Proteomic identification and functional characterization of anovel ARF6 GTPase-activating protein, ACAP4. Molecular & CellularProteomics. 2006.8.01, 5(8):1437-1449.

27. Edelstein Leonard C, LunaElizabeth J, Gibson IanB, Bray Molly, Jin Ying, Kondkar Altaf, NagallaSrikanth, Hadjout-Rabi Nacima,Smith Tara C, Covarrubias Daniel, Jones StephenN, Ahmad Firdos, Stolla Moritz, Kong Xianguo, Fang Zhiyou, Bergmeier Wolfgang,Shaw Chad, Leal Suzanne M, Bray Paul F. Human genome-wide association and mouseknockout approaches identify platelet supervillin as an inhibitor of thrombus formationunder shear stress. Circulation, 2012, 125(22):2762-2771.

28. Bhuwania Ridhirama, CornfineSusanne, Fang Zhiyou, Kruger Marcus, Luna Elizabeth J , Linder Stefan*.Supervillin couples myosin-dependent contractility to podosomes and enablestheir turnover. Journal of Cell Science. 2012, 125(Pt 9): 2300-2314.

29. Smith Tara C, Fang Zhiyou, LunaElizabeth J*. Novel interactors and a role for supervillain in earlycytokinesis. Cytoskeleton (Hoboken), 2010,67(6): 346-364.

30. Crowley Jessica L, Smith TaraC, Fang Zhiyou, Takizawa Norio, Luna Elizabeth J*. Supervillin reorganizes theactin cytoskeleton and increases invadopodial efficiency. Molecular Biology ofthe Cell. 2009, 20(3):948-962.