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徐明
（醫學博士）
鎖定
徐明人生經歷
1988年，考取世界衞生組織獎學金赴日本留學工作
2001年，出任湖南醫科大學分子藥理研究室主任和教授
徐明社會任職
徐明主要代表論文
1、天然（植）藥物有效組分的提取及天然活性組分添加劑的研究與應用
Jian Bo Xiao, Chun Sheng Yang, Fen Lian Ren, Xin Yu Jiang, Ming Xu. Rapid Determination of Ciprofloxacin Lactate in Drugs by Rayleigh Light Scattering Technique. Measurement Science & Technology, 2007, 18(3):859-866
[1]
2、主持和指導 DADS 等藥物抗癌的分子藥理學機理研究
Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells
[2]
3、研究了神經細胞凋亡抑制蛋白(NAIP)基因調控區結構，克隆並查明瞭包括啓動子在內的調控區DNA片段的多種功能及其特異性
4、利用真核細胞基因敲除技術研究了 sno 基因的功能 , 建立了惡性淋巴瘤的動物模型
Shinagawa T, Dong HD, Xu M, Maekawa T, Ishii S. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice. EMBO J. 2000 May 15;19(10):2280-91.
[4]
5、分離了一個新型霍亂菌株，並在分子水平上查明瞭該菌株分泌的異型毒素功能
Amino acids of the cholera toxin from Vibrio cholerae O37 strain S7 which deffer from those of strain
[5]
6、開發了原核生物體基因敲除技術；從副溶血弧菌中成功地敲除了TRH毒素基因,首次在細菌生物體內證實了TRH毒素蛋白病原性
Xu M, Yamamoto K, Honda T. Construction and characterization of an isogenic mutant of Vibrio parahaemolyticus having a deletion in the thermostable direct hemolysin-related hemolysin gene (trh). J Bacteriol. 1994 Aug;176(15):4757-60.
[6]
- 參考資料
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- 1. Rapid determination of ciprofloxacin lactate in drugs by the Rayleigh light scattering technique ．IOP PublishingTerms & conditionsDis[引用日期2021-07-13]
- 2. Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells ．Springer Nature Switzerland AG. Part of Springer Nature[引用日期2021-07-13]
- 3. Functional human NAIP promoter transcription regulatory elements for the NAIP and NAIP genes ．ingenta connect[引用日期2021-07-13]
- 4. The sno gene, which encodes a component of the histone deacetylase complex, acts as a tumor suppressor in mice ．The EMBO Journal[引用日期2021-07-13]
- 5. Amino acids of the cholera toxin from Vibrio cholerae 037 strain S7 which differ from those of strain O1 - ScienceDirect ．ScienceDirect[引用日期2021-07-13]
- 6. Construction and characterization of an isogenic mutant of Vibrio parahaemolyticus having a deletion in the thermostable direct hemolysin-related hemolysin gene (trh) ．Journal of Bacteriology[引用日期2021-07-13]
- 7. 中國民族醫藥協會微生態分會成立 - 新湖南 ．湖南日報[引用日期2021-07-13]
- 8. 走在中醫藥傳承與創新路上 ——記中南大學分子藥物與治療研究所所長、教授、醫學博士 - 民族人物 ．雲南民族旅遊網[引用日期2021-07-13]
