複製鏈接
請複製以下鏈接發送給好友

徐強

(南京大學生命科學學院教授)

鎖定
徐強,南京大學生命科學學院教授博士生導師、副院長,醫藥生物技術國家重點實驗室PI,課題組長。國家傑出青年科學基金獲得者。 [1] 
中文名
徐強
專業方向
免疫藥理學、分子藥理學
任職院校
南京大學
職    稱
教授

徐強學術兼職

擔任國際刊物Journal of Pharmacological Sciences雜誌副主編以及Biochemical Pharmacology、Journal of Traditional Medicines、Asian Journal of Traditional Medicines、《中國藥理學通報》《中國免疫學雜誌》《中國天然藥物》等雜誌的編委。國家藥品審評專家,國家中藥品種保護審評委員會委員,中國藥理學會抗炎免疫藥理專業委員會副主任委員,中國藥理學會中藥藥理專業委員會常委,江蘇省藥理學會副理事長。 [1] 

徐強研究方向

主要從事免疫藥理學、分子藥理學等領域的研究。以藥理學為橋樑,研究觸角向基礎醫學、臨牀醫學和化學生物學自然交叉延伸,實現從新的角度闡釋疾病的發生發展機理、尋找新的藥物作用靶點或生物分子事件、進而研製新型藥物的目標。主要研究方向包括:免疫應答與炎症的分子基礎及其選擇性調控;炎-癌轉化的分子機制研究;基於小分子化合物作用特點的化學生物學研究等。 [1] 

徐強代表論文

代表性論著(*通訊作者)
1. Wenjie Guo,Yang Sun,Wen Liu,Xingxin Wu,Lele Guo,Peifen Cai, Xuefeng Wu,Xudong Wu,Yan Shen,Yongqian Shu,Yanhong Gu,Qiang Xu*. Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer.Autophagy 2014; 10(6):972–985.
2.Li Zhang, Yang Sun, Mingjian Fei, Cheng Tan, Jing Wu, Jie Zheng, Jiqing Tang, Wei Sun, Zhaoliang Lv, Jiandong Bao, Qiang Xu* and Huixin Yu. Disruption of chaperone-mediated autophagy dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization. Autophagy 2014; 10(6):1015-35.
3.Li W, Ouyang Z, Zhang Q, Wang L, Shen Y, Wu X, Gu Y, Shu Y, Yu B, Wu X, Sun Y, Xu Q*. SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2. Cell Death Dis2014; 5: e1581.
4.Wang X, Zhang A, Gao J, Chen W, Wang S, Wu X, Shen Y, Ke Y, Hua Z, Tan R, Sun Y, Xu Q*. Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis. J Invest Dermatol2014; 134(11): 2737-46.
5.Luo Q, Sun Y, Gong FY, Liu W, Zheng W, Shen Y, Hua ZC, Feng GS, Xu Q*. Blocking initial infiltration of pioneer CD8+ T cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice. Br J Pharmacol2014; 171: 1706-21.
6. WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo*, Q Xu*, Y Sun*. Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells distinct from cisplatin. Autophagy 2013; 9: 996-1008.
7. Q Luo, Y Sun*, W Liu, C Qian, B Jin, F Tao, Y Gu, X Wu, Y Shen, Q Xu*. A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.J Immunol2013; 191: 4969-4978.
8.. T Zhang, W Guo, Y Yang, W Liu, L Guo, Y Gu, Y Shu, L Wang, X Wu, Z Hua, Y Ke, Y Sun, Y Shen, Q Xu*. Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis. Sci Rep 2013; 3: 2845.
9. X Wu, W Guo, L Wu, Y Gu, L Gu, S Xu, X Wu, Y Shen, Y Ke, R Tan, Y Sun, Q Xu*. Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis. J Immunol 2012, 189: 3497-3507.
10. L Wang, L Wang, Y Gu, Y Shu, Y Shen,Q Xu*. Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma. Mol Cancer Ther 2011; 10: 2276-2286.
11. L Wang, L Wang, R Song, Y Shen, Y Sun, Y Gu, Y Shu, Q Xu*. Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma. Mol Cancer Ther 2011; 10: 461-471.
12. W Zhao, Y Gu, R Song, B Qu, Q Xu*. Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation. Leukemia 2008; 22(6): 1226-33.
13. J Guo, Q Xu*,T Chen. Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis. Clin Chem 2007; 53: 465-471.
14. M Fei, X Wu, Q Xu*. Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A. J Allergy Clin Immunol 2005; 116(6): 1350-1356.
15. X Wu,H Zeng, X Zhang,Y Zhao,H Sha, X Ge, M Zhang, X Gao, Q Xu*. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells. Am J Pathol 2004; 164(6): 2039-2054. [1] 

徐強獲獎記錄

獲第四屆中國青年科技獎(1994年),首屆吳階平-保羅楊森醫藥學研究獎二等獎(1994年),入選教育部跨世紀優秀人才培養計劃(1995年);國家中青年有突出貢獻專家稱號(1996年);首屆江蘇青年科學家獎提名獎(1996年);國家傑出青年科學基金獲得者(1999年)。作為第一完成人獲2011年度教育部自然科學一等獎。 [1] 
參考資料