彭英

1997.11-2001.9：美國國立衞生研究院博士後

2000.4-2000.5：美國紐約冷泉港實驗室發育與功能基因培訓班學員

1989.9-1992.7：中山醫科大學神經病學博士研究生獲博士學位

1986.9-1989.7：第三軍醫大學神經病學碩士研究生獲碩士學位

1978.9-1983.7：湖南衡陽醫學院醫療係獲學士學位 ^[2] 

腦損傷機制及神經發育再生；

神經腫瘤及基因治療。 ^[1] 

腦血管疾病、老年性和血管性痴呆、神經病理性疼痛、中毒性和放射性腦病的診治。 ^[2] 

中國醫師協會腦與脊髓損害專委會主任委員

中國中西結合學會神經病分會常委

中國卒中學會卒中康復分會副主任委員

廣東省醫學會罕見病分會副主任委員

廣東省醫師協會神經病學分會副主任委員

廣東省中西結合學會神經病分會副主任委員

廣東省神經藥理學會副主任委員

世界華人生活質素學會常務委員

第四屆國際中毒性損傷會議組委會委員

第二屆國際神經病理性疼痛專家委員會委員 ^[1] 

《中國神經精神疾病雜誌》副主編

《中山大學學報》醫學版編委

《中華腦科疾病與康復雜誌（電子版）》編委

《中國醫學與保健》編委

《中國神經再生雜誌》編委

《中華現代中西醫雜誌》編委

《國際腦血管病雜誌》編委

《中華現代影像學雜誌》常務編委

《國際神經病學神經外科雜誌》編委

《Journal of Cancer Metastasis and Treatment （JCMT）》Editor ^[1] 

1. Xiaoming Rong1, Bo Huang1, Shuwei Qiu2, Xiangpen Li1, Lei He1, Ying Peng*.Tumor-associated macrophages induce vasculogenic mimicry of glioblastoma multiforme through cyclooxygenase-2 activation. Oncotarget. 2016; In press.(IF:5.02)

2. Yin Y, Fu C, Li M, Li X, Wang M, He L, Zhang LM, Peng Y*.A pH-sensitive hyaluronic acid prodrug modified with lactoferrin for glioma dual-targeted treatment. Mater Sci Eng C Mater Biol Appl. 2016 Oct 1;67:159-69. doi: 10.1016/j.msec.2016.05.012.（IF：3.09）

3. Long X,Li Y, Qiu S, Liu J, He L, Peng Y*. MiR-582-5p/miR-590-5p targeted CREB1/CREB5-NF-κB signaling and caused opioid-induced immunosuppression in human monocytes.Transl Psychiatry. 2016 Mar 15;6:e757. doi: 10.1038/tp.2016.4. (IF：5.68)

4. Pan J, He L, Li X, Li M, Zhang X, Venesky J, Li Y, Peng Y*. Activating Autophagy in Hippocampal Cells Alleviates the Morphine-Induced Memory Impairment. Mol Neurobiol. 2016 Feb 13. [Epub ahead of print] （IF：5.397）

5. Pan J, Li X, Peng Y*.Remote ischemic conditioning for acute ischemic stroke:dawn in the darkness.Rev.Neurosci.2016 Jan19.pii: /j/revneuro.ahead-of-print/ revneuro -2015-0043/revneuro-2015-0043.xml. doi: 10.1515/revneuro-2015-0043. （IF:3.31）

6. Li H, Qiu S, Li X, Li M, Peng Y*.Autophagy biomarkers in CSF correlates with infarct size, clinical severity and neurological outcome in AIS patients. J Transl Med. 2015 Nov 14;13(1):359. doi: 10.1186/s12967-015-0726-3 (IF：3.93)

7. Yin Y, Qiu S, Peng Y*. Functional roles of enhancer of zeste homolog 2 in gliomas. Gene. 2015 Oct 13. pii: S0378-1119(15)01189-0. doi: 10.1016/j.gene.2015.09.080 (IF：2.138)

8. Huang D, Qiu S, Ge R, He L, Li M, Li Y, Peng Y*. MiR-340 suppresses glioblastoma multiforme. Oncotarget. 2015 Apr 20;6(11):9257-70.(IF:6.36)

9. Honghong Li, Lei He, Shuwei Qiu, Yi Li and Ying Peng*. Clinical Analysis in Chronic Alcoholic Encephalopathy: A Retrospective Study of 43 Subjects. Clinical Toxicology .2015; 5(2): 1-4

10. Peng Y*, Cooper SK, Li Y, Mei JM, Qiu S, Borchert GL, Donald SP, Kung HF, Phang JM*.Ornithine-a-aminotransferase inhibits neurogenesis during Xenopus embryonic development . Invest Ophthalmol Vis Sci. 2015 Mar 17. pii: IOVS-15-16509. doi: 10.1167/iovs.15-16509. [Epub ahead of print] (IF:3.6)

11. Yue PJ, He L, Shen QY, Qiu SW, Rong XM, Gong HX, Peng Y*. Long-term toxicity study of rAd5-hTERTC27 in SD rats and Cynomolgus monkeys by intravenous injection. Regul Toxicol Pharmacol. 2015 Mar;71(2):285-94. doi: 10.1016/j.yrtph.2014.12.022. Epub 2015 Jan 13.555PMID:25592546（IF:2.14)

12. Qiu S, Feng Y, LeSage G, Zhang Y, Stuart C, He L, Li Y, Caudle Y, Peng Y*, Yin D*.Chronic Morphine- Induced MicroRNA-124 Promotes Microglial Immunosuppression by ModulatingP65 and TRAF6. J Immunol. 2015 Feb 1;194(3):1021-30. doi: 10.4049/jimmunol.1400106. PMID:25539811 (IF:5.4)

13. Hu J, Li Y, Chen L, Yang Z, Zhao G, Wang Y, Cheng J, Zhao J, Peng Y*. Impact of IL-22 gene polymorphism on human immunodeficiency virus infection in Han Chinese patients.J Microbiol Immunol Infect. 2014 Nov 11. pii: S1684-1182(14)00226-6.doi:10.1016/j.jmii. 2014.09.002. (IF:2.35)

14. Wang Y, Li Y, Shen Q, Li X, Lu J, Li X, Yin D, Peng Y*.Valsartan blocked alcohol-induced, toll-like receptor 2 signaling-mediated inflammation in human vascular endothelial cells. Alcohol Clin Exp Res. 2014 Oct;38(10):2529-40. doi: 10.1111/acer.12532. (IF:3.31)

15. Wu Y, Peng Y*, Wang Y*.An insight into advances in the pathogenesis and therapeutic strategies of spinocerebellar ataxia type3. Rev Neurosci. 2014 Sep 12. pii: /j/revneuro ahead-of-print/revneuro- 2014-0040/revneuro-2014-0040.xml. doi: 10.1515/revneuro- 2014-0040. (IF:3.31)

16. Li XP, He L, Wang YD, Li Y, Li M, Peng Y*. Identification of Potential Biomarkers for Artificial Cold Exposure-induced Hypertensive Stroke by Proteomic Analysis. J Stroke Cerebrovasc Dis. 2014 Oct 9. pii: S1052-3057(14)00296-1.doi:10.1016/j.jstrokecerebrovasdis.2014.06.014.

17. Yue PJ, He L, Qiu SW, Li Y, Liao YJ, Li XP, Xie D, Peng Y*. OX26/CTX-conjugated PEGylated liposome as a dual-targeting gene delivery system for brain glioma. Mol Cancer. 2014 Aug 13;13(1):191. doi: 10.1186/1476-4598-13-191. (IF:5.88)

18. Chen S, Shen Q, Tang Y, He L, Li Y, Li H, Li M, Peng Y*. Efficacy and Safety of Adding Clopidogrel to Aspirin on Stroke Prevention among High Vascular Risk Patients: A Meta-Analysis of Randomized Controlled Trials. PLoS One. 2014 Aug 11;9(8):e104402. doi: 10.1371/journal.pone.0104402. eCollection 2014. (IF:3.53)

19. Wang H, Tang Y, Rong X, Li H, Pan R, Wang Y, Peng Y*. Effects of early blood pressure lowering on early and long-term outcomes after acute stroke: an updated meta-analysis. PLoS One. 2014 May 22;9(5):e97917.doi: 10.1371/journal.pone.0097917. eCollection 2014 (IF:3.53)

20. Zheng D,Li Y, He L, Tang Y, Li X, Shen Q, Yin D, Peng Y*.The protective effect of astaxanthin on fetal alcohol spectrum disorder in mice. Neuropharmacology.2014 Apr 26; 84C:13-18. doi: 10.1016 /j.neuropharm. 2014.04.013. [Epub ahead of print] (IF:5.2)

21. Zheng D, Li Y, Liu Y, Rong X, Tang Y, Peng Y*, Shen Q*. Hypokalemia in Patients With Cough Mixture Abuse: A Retrospective Chart Review. J Addict Med. 2014 Apr 4. [Epub ahead of print] (IF:1.7)

22. Ling Long, Weiwei Wang, Xia‑Dong Cai, Du Cheng, Xintao Shuai and Ying Peng*. PinX1‑siRNA/ mPEG‑PEI‑SPION combined with doxorubicin enhances the inhibition of glioma growth. Experimental and Therapeutic Medicine. 2014; 7: 1170-1176 (IF:0.344)

23. Lu J, Luo H, Liu X,Peng Y*, Zhang B, Wang L, Xu X, Peng X, Li G, Tian W, He M, Hsiangfu K, Li X*. MiR-9 targets CXCR4 and functions as a potential tumor suppressor in nasopharyngeal carcinoma. Carcinogenesis. 2014 Mar;35(3):554-63.doi: 10.1093/carcin /bgt354 (IF:5.27)

24. Lu J, Xu X, Liu X, Peng Y*, Zhang B, Wang L, Luo H, Peng X, Li G, Tian W, He M, Li X*. Predictive value of miR-9 as a potential biomarker for nasopharyngeal carcinoma metastasis. Br J Cancer. 21;110(2):392-8. doi: 10.1038/bjc.2013.751.(IF:5.2)

25. Peng Y, Lu K, Li Z, Zhao Y, Wang Y, Hu B, Xu P, Shi X, Zhou B, Pennington M, Chandy KG, Tang Y*.Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.Neuro Oncol. 2014 Apr;16(4):528-39. doi: 10.1093/neuonc/not221. Epub 2013 Dec 4.(IF:7.18)

26. Liu X, Luo HN, Tian WD, Lu J, Li G, Wang L, Zhang B, Liang BJ, Peng XH, Lin SX, Peng Y*, Li XP. Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma. Cancer Biol Ther. 2013 Aug 23;14(12). [Epub aheadof print] (IF:3.33)

27..He L, Li M, Long XH, Li XP, Peng Y*. A case of Hashimoto's encephalopathy misdiagnosed as viral encephalitis. Am J Case Rep. 2013 Sep 13;14:366-9. doi: 10.12659/AJCR.889312.

28.Lei He, Han-Xian Gong, Xiang-Pen Li, Yi-Dong Wang, Yi Li, Jun-Jian Huang, Dan Xie, Hsiang-Fu Kung and Ying Peng*. Inhibition of hepatocellular carcinoma growth by adenovirus‑mediated expression of human telomerase reverse transcriptase COOH-27 terminal polypeptide in mice. Oncology Letters .2013; 6: 748-752,(IF:0237)

29.Yue PJ, He L, Li Y, Shen QY, Li M, Huang DQ, Huang JJ, Peng Y*. Preclinical Safety Evaluation of rAd5-hTERTC27 by intravenous injection. Regul Toxicol Pharmacol. 2013 Jul 1. pii: S0273-2300(13) 00099-8(IF:2.39)

30. Li C, Li X, Shen Q, Li Y, He L, Li M, Tang Y, Wang Y, He Q, Peng Y*.Critical Role of Matrix Metalloproteinase-9 in Acute Cold Exposure-Induced Stroke in Renovascular Hypertensive Rats. J Stroke Cerebrovasc Dis. 2013 Jun 22. doi:pii: S1052-3057(13)00183-3.(IF:1.98)

31. Qiu S, Huang D, Li F, Yin D, Kung HF, Peng Y*. Suppression of tumorigenicity by MicroRNA-138 through inhibition of EZH2-CDK4/6-pRb-E2F1 signal loop in glioblastoma multiforme. BBA-MOL BASIS DISa. 2013 May 22;1832(10):1697-1707. (IF:5.23)

32. Qiu S, Lin S, Hu D, Feng Y, Tan Y, Peng Y*，Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients. J Transl Med. 2013 Jan 9;11:10. doi: 10.1186/1479-5876-11-10.(IF:3.9)

33. Li H, Pan R, Wang H, Rong X, Yin Z, Milgrom DP, Shi X, Tang Y, Peng Y*. Clipping Versus Coiling for Ruptured Intracranial Aneurysms: A Systematic Review and Meta-Analysis. Stroke. 2013; 44(1):29-37(IF:6.83)

34. Kui Lu, Jue Wang, Bin Hu, Xiaolei Shi, Junyi Zhou, Yamei Tang , Ying Peng* Brilliant blue G attenuates lipolysaccharide- mediated microglial activation and inflammation. Neural Regeneration Research 2013; 8(7): 599-608(IF:0.144)

35. Liu X, Lu J, He ML, Li Z, Zhang B, Zhou LH, Li Q, Li G, Wang L, Tian WD, Peng Y, Li XP. Antitumor effects of interferon-alpha on cell growth and metastasis in human nasopharyngeal carcinoma. Curr Cancer Drug Targets. 2012 ;12(5):561-70.(IF:3.84)

36. Li D, Li XP, Wang HX, Shen QY, Li XP, Wen L, Qin XJ, Jia QL, Kung HF, Peng Y*. VEGF induces angiogenesis in a zebrafish embryo glioma model established by transplantation of human glioma cells. Oncol Rep. 2012; 28(3):937-42.(IF:2.297)

37. Gong HX, He L, Li XP, Wang YD, Li Y, Huang JJ, Wang Z, Xie D, Kung HF, Peng Y*. Effective antitumor immunity against murine gliomas using dendritic cells transduced with hTERTC27 recombinant adenovirus. Oncol Rep. 2012 ;27(4):1163-9.(IF:2.297)

38. Yamei Tang, Xiangpen Li,Yi Li,Qingyu Shen, Xiaoming Rong, Ruxun Huang, Ying Peng*. Renovascular hypertension causes cerebral vascular remodeling. Neural Regeneration Research .2011; 6(25): 1977-1981(IF:0144)

39. He L, Li H, Chen L, Miao J, Jiang Y, Zhang Y, Xiao Z, Hanley G, Li Y, Zhang X, Lesage G, Peng Y*, Yin D*.Toll-like receptor 9 is required for opioid-induced microglia apoptosis. PLoS One. 2011 ; 29;6(4):e18190.(IF 4.41 )

40. Y. Tang, Q. Shen, Y. Wang, K. Lu, Y. Wang, Y. Peng*. A Randomized Prospective Study of Rehabilitation Therapy in the Treatment of Radiation-induced Dysphagia and Trismus. Strahlenther Onkol. 2011;187: 39-44 (IF 4.16 )

41. Kou Peng2, Yi Li1, Ling Long1, Dong Li2, Qiuli Jia2, Yidong Wang1, Qingyu Shen1, Yamei Tang1, Lu Wen2, Hsiang-fu Kung2, Ying Peng*, Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafish. Neuroscience Lett 2010; 484(2):98-103 (IF 2.2 )

42. Ling Long, Yi Li, Yidong Wang, Qing Yu He, Mei Li, Xiao Dong Cai, Kou Peng, Xiang Pen Li, Dan Xie, Yan Ling Wen, De LingYin, and Ying Peng* .The preventive Effect of Oral EGCG ina Fetal Alcohol Spectrum disorder Mouse Model. Alcoholism: Clinical and Experimental Research 2010；34(11):1929-1936 (IF:3.4)

43. Dong Li，Kou Peng，Yi Li，Ying Peng*. Advancements on the Zebrafish of Glioma model. Chinese Journal of Cancer 2010; 29(6):621-5. (IF: 0.2)

44. Li Y, Li H, Zhang Y, Sun X, Hanley G, Zhang Y, Sun S, Peng Y*, and Yin D*. Toll-like receptor 2 is required for opioids-induced neuronal apoptosis. Biochem Biophys Res Commun. 2010, 391(1): 426-430. （IF:2.93）

45. Liang B, He ML, Chan CY, Chen YC, Li XP, Li Y, Zheng D, Lin MC, Kung HF, Shuai XT, Peng Y*. The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat. Biomaterials 2009, 30(23-24):4014-4020.(IF:8.3)

46. Li Y, Sun Z, Zhang Y, Huang J, Hanley G, Ferslew K, Peng Y*, and Yin D. Morphine promotes apoptosis via TLR2, and this is negatively regulated by beta-arrestin 2. Biochem Biophys Res Commun. 2009, 378(4):857-861. （IF:2.93）

47. Liang B, He ML, Xiao ZP, Li Y, Chan CY, Kung HF, Shuai XT, Peng Y*. Synthesis and characterization of folate-PEG-grafted-hyperbranched-PEI for tumor-targeted gene delivery. Biochem Biophys Res Commun. 2008, 367(4):874-880.（IF:2.93）

48. Ruiyan Lu, Qingyu Shen, Lianhong Yang, Mei Li, Yidong Wang, Ying Peng*. Effects of Kallikrein gene transfer on penumbral microvascular proliferation and regional cerebral blood flow following cerebral ischemia/reperfusion injury. Neural Regen Res 2008, 3:1045-50.

49. Ruiyan Lu, Lianhong Yang, Qingyu Shen, Mei Li, Xiangpen Li, Ying Peng*. Stereotaxic microinjection of adenovirus-mediated human tissue Kallilrein gene reduces apoptosis in a rat model of middle cerebral artery occlusion. Neural Regen Res 2008, 3: 847-52.

50. Li X, Liu X, Li C, Ding Y, Chau D, Li G, Kung HF, Lin M, and Peng Y*. Recombinant adeno-associated virus (rAAV) mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells in vivo and in vitro by suppression of Epstein-Barr virus encoded LMP-1. International Jorunal of Oncololgy 2006, 29(3):595-603.

51. Li X, Li C, Li X, Ding Y, Chan L, Yang P, Li G, Liu X , Lin J, Wang J, He M, Kung HF, Lin M and Peng Y*.Inhibition of Human Nasopharyngeal Carcinoma Growth and Metastasis in Mice by Adenovirus-associated Virus Mediated Expression of Human Endostatin. Molecular Cancer Therapeutics 2006, 5(5):1290-8.(IF:5.22)

52. Ying Peng, Pai-Hao Yang, Julian A.Tanner, Jian-Dong Huang, Ming Li, Henry F. Lee, Ren-He Xu, Hsiang-Fu Kung, and Marie C. Lin*. Cold-inducible RNA binding protein is required for expression of adhension molecules and embryonic cell movement and in Xenopus Laevis. B.B.R.C. 2006, 344(1): 416-426.

53. Ying Peng*, K-H Kwok, Pai-Hao Yang, Jie Liu, Ming-Liao He, Peter Fung, Hsiang-fu Kung and Marie C.M. Lin*. Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly. Neuropharmacology 2005, 48: 426- 434.(IF:5.12) ^[3] 

54. Ying Peng, Pai-Hao Yang, K.H.H.Kwok, Yan Guo, Jie Liu, Ming-liang He,Samuel S.M.Ng, Jie Ge, Hsiang-fu kung and Marie C.M. Lin*. Protection of Xenopus Embryos Against Alcohol- induced Growth Retardation and Delayed gut Development by Peroxyredoxin. Journal of Molecular Biology 2004; 340: 819-27.(IF:5.02)

55. Ying Peng, Pai-hao Yang, Oscar G. Wong, Samuel S.M. Ng, Jie Liu, Ming-Liang He, Hsiang-fu Kung and Marie Lin*. A Critical Role of Pax6 in Alcohol-induced Fetal Microcephaly. Neurobiology of Disease 2004; 16 (2): 370-376.(IF:5.12)

56. Ying Peng. Bing-Hua Jiang, Pai-Hao Yang, Zongxian Cao, Xianglin Shi, Marie C.M. Lin, Ming-Liang He, and Hsiang-fu Kung*. Phosphatidylinositol-3 kinase signalings is involved in neurogenesis during Xenopus embryonic development. Journal of Biological Chemistry 2004;279(27):28509-14.(IF:6.35)

57.Ying Peng, Pai-Hao Yang, Yan Guo, Samuel S.M. Ng, Jie Liu, P.C. W. Fung, David Tay, Jian Ge, Ming-Liang He, Hsiang-fu Kung, and Marie. C. Lin*. Catalase and Peroxiredoxin 5 Protect Xenopus Embryos Against Alcohol-Induced Ocular Anomalies. Investigation Ophthalmology & Visual Science 2004; 45: 23-29 (IF: 3.93)

58. Xiang-Ping Li, Gang Li, Ying Peng, Hsiang-fu kung, and Marie C. Lin*. Suppression of Epstein-Barr virus-encoded latent membrane protein-1 by RNA interference inhibits the metastatic potential of nasopharyngeal carcinoma cells. Biochemical and Biophysical Research Communications 2004; 315: 212-218 (Co-first author) (IF:2.904)

59. Ying Peng, Ren-He Xu, Jay Ming Mei, Xiang-Ping Li, Donghong Yan, Hsiang-fu Kung, James M. Phang*. Neural inhibition by c-Jun as a synergizing factor in BMP-4 signaling. Neuroscience 2002; 109(4): 657-664 (IF:3.456)

60. Ying Peng, K.H. Kok, Ren-He Xu, K.H.H. Kwok, P.C.W. Fung, Hsiang-fu Kung*, and Marie C.M. Lin. Maternal Cold Inducible RNA Binding Protein is required for Xenopus laevis Embryonic Development and kidney formation FEBS Letter 2000; 482: 37-43 (IF: 3.843) ^[1] 

1、《腦梗死治療學》主編：彭英，王藝東，黃如訓。北京，人民衞生出版社。2010年3月

2、《中毒性腦病》主編：彭英。北京，人民衞生出版社。2011年8月

3、《放射性神經損傷》主編：唐亞梅，彭英。北京，人民衞生出版社。2012年7月

1、《腦卒中》主編：黃如訓，蘇鎮培 ；參編：彭英。北京，人民衞生出版社。2001年11月

2、《腦卒中》第二版，主編：黃如訓，蘇鎮培； 參編：彭英。北京，人民衞生出版社。2012年12月

3、《個體化醫學原則》主編：黃文林， 參編：彭英。北京，人民衞生出版社。2013年1月

1、《神經病學》國家衞生和計劃生育委員會“十二五” 規劃教材，第3版，主編：肖 波，參編：彭英。北京，人民衞生出版社。2013年1月

2、《神經病學》“十二五” 普通高等教育本科國家級規劃教材，中國高等教育學會醫學教育專業委員會規劃教材 第3版，主編：王擁軍 北京，參編：彭英。北京大學醫學出版社，2013年12月

3、《神經病學》國家醫學電子書包 ，主編：王擁軍 ，參編：彭英。北京，人民軍醫出版社，2016年

1、項目名稱：高血壓動脈硬化性腦梗死的病理機制及臨牀系列研究。廣東省科技進步二等獎，獲獎單位：中山醫科大學附屬第一醫院，第一軍醫大學南方醫院。1996年， 合作單位排名第一。

2、項目名稱：高血壓致腦血管損害及對梗塞影響的實驗研究。軍隊科技進步獎二等獎，獲獎單位：第一軍醫大學南方醫院。1997年，排名第一。

3、項目名稱：Neural inhibition by c-Jun as a synergizing factor in BMP-4 signaling. 美國國立衞生研究院傑出研究獎。 獲獎單位：美國國立衞生研究院國立癌症研究所基礎醫學實驗室，2001年。排名第一。

4、項目名稱：理化因素所致神經系統損傷的機制及干預。廣東省科技進步二等獎，獲獎單位：中山大學孫逸仙紀念醫院，2014年，排名第一。 ^[1] 

1、建立了多種酒精中毒性腦損傷小動物模型，發現了酒精所致神經發育障礙的關鍵靶基因，闡明瞭酒精緻腦損傷的過氧化物損傷機制。

2、發現Toll受體在腦卒中後的缺血性腦損傷中起重要作用，可作為缺血性腦損傷的干預靶點。

3、發明了一種既能夠通過血腦屏障又能靶向到膠質瘤的基因載體，動物實驗證明，其攜帶腫瘤抑制基因能明顯抑制膠質瘤的增值和生長。

在SCI雜誌發表論文99篇，總影響因子371.13分。以第一作者和通信作者發表論文60篇，其中影響因子5分以上文章17篇。單篇它引率最高55次。獲得國家級基金11項，省部基金15項，獲得美國發明專利和中國發明專利各一項。獲得軍隊科技進步二等獎一項，廣東省科技進步二等獎二項。 ^[1] 

1. 國家自然科學基金：神經發生啓動基因的分離（1997-2000）項目編號：39870207，項目經費：13萬，主持。

2. 國家自然科學基金：ARF6基因在神經發育中的功能作用及與P13K的相互關係（2005-2007）項目編號：30570589，項目經費：10萬，主持。

3. 國家自然科學基金：修飾型PPE-EA介導caspase-8CD基因聯合治療神經膠質瘤的研究（2007-2009）項目編號：30672411項目經費：28萬，主持。

4. 863重點項目課題：利用hTERTC27多肽基金病毒疫苗抗癌的治療研究（2008-2012）項目編號：2007AA021101，項目經費：390萬，主持。

5. 國家“十一五”科技支撐計劃重大項目分題：缺血中風綜合防治方案和療效評價的示範研究（2007-2009）項目編號：2006BA104A02，項目經費：4萬， 主持。

6. 國家自然科學基金：TfR抗體和CTX修飾納米載體介導hTERTC27治療神經膠質瘤（2010-2012）項目編號：30973479，項目經費：32萬，主持。

7. 國家自然科學基金：Foxo3a在神經發育過程的功能作用及信號傳導（2011-2013）項目編號：31070953，項目經費：35萬， 主持。

8. 國家“十二五”科技支撐計劃課題分題：腦血管病整體康復適宜技術的開發推廣及康復信息平台的建設（2012-2015）項目編號：2011BAI08B11 ，項目經費：3.5萬， 主持。

9. 國家自然科學基金：EZH2信號環路的相互作用及對神經膠質瘤細胞週期、增殖與侵襲的影響（2013-2016）項目編號：81272197，項目經費：70萬，主持。

10. 國家自然科學基金海外和港澳合作基金：TLR2介導小膠質細胞激活在嗎啡依賴中的作用（2013-2014）項目編號：81228010，項目經費：20萬，主持。

11. 國家自然科學基金：IL-6家族與miR-340交互負反饋調控膠質瘤免疫抑制的功能與機制研究 (2016-2019) 項目編號：81572481, 項目經費：60萬，主持。

12. 國家自然科學基金重點課題培育項目：miR-7在神經膠質瘤轉移的作用機制及靶向干預的新策略（2011-2013）項目編號：10ykjc26，項目經費：20萬，主持。 ^[1]