張銘湘

1985, 09---1989, 07 曲阜師範大學生物學專業學習 , 取得學士學位

1989, 09---1992,07 山東醫科大學醫學遺傳學專業學習 , 取得碩士學位

1998, 09---2001,07 中南大學湘雅醫學院醫學遺傳學國家重點實驗室學習 , 取得博士學位

1992, 09—2001,07 在山東省立醫院工作

2001, 09---2007,11 在美國 Baylor 醫學院做高級訪問學者

2007, 11--- 至今 山東大學齊魯醫院心血管重構與功能研究教育部與衞生部重點實驗室工作

學術身份 : 教育部 985 特聘教授 ,山東大學齊魯學者, 美國心臟學會會員 , 美國神經學會會員。

動脈粥樣硬化形成的分子病理機制與心腦血管疾病的相互關係及遺傳因素所致的心腦血管疾病的發病機理。

· Zhang MX , Zhang C, Shen YH, Burks JK, Zhang Y, Wang J, Yoshimura K,AOKIH, Coselli JS, Wang XLbiogenesisof short intronic repeat 27-nucleotide small RNA from endothelial nitric-oxide synthase gene.J Biol Chem. 2008 May 23;283(21):14685-93. Epub 2008 Apr 3.

· Zhang MX , Zhang C, Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. Effect of 27nt Small RNA on Endothelial Nitric Oxide Synthase Expression. (In press) Molecular Biology of The Cell.

· Zhang MX , Ou H, Shen YH, Wang J, Wang J, Coselli J, Wang XL. Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci U S A . 2005 Nov 22; 102(47):16967-72. Epub 2005 Nov 11

· Zhang C, Zhang MX , Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. Role of NonO-histone interaction in TNFalpha-suppressed Prolyl-4-hydroxylase alpha1. Biochim Biophys Acta. 2008 Aug; 1783 ( 8 ): 1517-1528 . Epub 2008 Mar 29.

· Kumar V, Zhang MX , Swank MW, Kunz J, Wu GY. Regulation of dendriticMorphogenesisby Ras-pi3k-AKT-mTOR and Ras-MAPK signaling pathways. J Neurosci . 2005 Dec 7:25(49):11288-99

· Zhang C, Zhang MX , Shen YH, Burks JK, Zhang Y, Wang J, LeMaire SA, Yoshimura K, Aoki H, Coselli JS, Wang XL. TNF-alpha suppresses prolyl-4-hydroxylase alphal expression via the ASK1-JNK-NONO pathway. Arterioscler Thromb Vasc Biol . 2007 Aug; 27(8):1760-7. Epub 2007 May 3.

· Wang XL, Zhang L, Youker K, Zhang MX , Wang J, LeMaire SA, Coselli JS, Shen YH. Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulatingPTENor inhibiting Akt kinase. Diabetes. 2006Aug; 55(8):2301-10

· Li AG, Lu SL, Zhang MX , Deng C, Wang XJ. Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis. Cancer Res . 2004 Nov 1; 64 (21): 7836-45

· Liu P, Zhang C, Feng JB, Zhao YX, Wang XP, Yang JM, Zhang MX, Wang XL, Zhang Y. Cross-Talk Among Smad, MAPK, and Intergrin Signaling Pathways Enhances Adventitial Fibroblat Functions Activated by Transforming Growth factor –beta1 andinhibitedby GAX. Arterioscler Thromb Vasc Biol. 2008 Jan 10;

· Utama B, Shen YH, Mitchell BM, Makagiansar IT, Gan Y, Muthuswamy R, Duraisamy S, Martin D, Wang X, Zhang MX, Wang J, Vercellotti GM, Gu W , Wang XL. Mechanisms for human cytomegalovirus-induced cytoplasmic p53 sequestration in endothelial cells. J Cell Sci . 2006 Jun 15; 119 (Pt 12): 2457-67. Epub 2006 May 23.

· Zhang MX, C. Hong; V.Kumar; Y. Hsueh; G.Y. Wu. NF1 Signaling And Dendritic Spine Morphogenesis Soc. Neurosci. Abstr . 388.14(San Diego, October 2004)

· Zhang MX, C.J. Hong, Kumar V. Hsueh, Y.P. and Wu, G.Y. Neurofibromin/Syndecan-2/caskprotein complex and dendritic spine morphogenesis. Soc. Neurosci. Abstr. 457.5.(New Orleans, October 2003 )

· Zhang MX, Shen YH, Zhang C, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL. Endogenous eNOS-Specific 27nt MicroRNA is derived through pre-Mrna Splicing. Circulation 2006 Oct Vol(114) 484

· Zhang MX, Shen YH, Zhang C, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL. Endogenous 27nt microRNA inhibits eNOS expression through DNA Methylation. Circulation 2006 Oct Vol(114) 1394

· Zhang C, Zhang MX, Shen YH, Burks JK, LeMaire SA, Wang J, Coselli JS, Wang XL.TNF-αSupresses prolyl-4-hydroxylase a(1)expression and collagen processing in Aortic SMCs via JNK pathway. Circulation 2006 Oct Vol(114) 1462

· Zhang, M.X . , C. Hong; V.Kumar; Y. Hsueh; G.Y. Wu. NF1 Signaling And Dendritic Spine Morphogenesis Soc. Neurosci. Abstr. 388.14(San Diego, October 2004)

· Zhang, M.X . , C.J. Hong, Kumar V. Hsueh, Y.P. and Wu, G.Y. Neurofibromin/Syndecan-2/CASK protein complex and dendritic spine morphogenesis. Soc. Neurosci. Abstr. 457.5.(New Orleans, October 2003 )

· Zhang HB, Li XQ, Zhang MX . Effect of naoyi'an on basic fibroblastic growth factor mRNA expression and tumor necrosis factor protein expression in brain of rats following intracerebralhemorrhage Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 Jul;22(7):518-21. Chinese.

· 張華標 ,李星羣, 張銘湘 (2002) NYA 對腦溢血大鼠大腦皮層 bFGF 的 mRNA 及蛋白質表達的影響 . 卒中及神經病學雜誌 , Aug, Vol.(9), No.4

· 張銘湘 , 文鍵 , 夏家輝 (2002) 一種簡便有效構建基因突變體的方法 . 中華醫學遺傳學雜誌 , April, Vol, 19 (2), 145-149.19 (2), 145-149.

1. 承擔國家 973 課題“動脈粥樣硬化分子機理的基礎研究 ”項目 , 20 萬元

2.教育部985 科技平台項目啓動經費 20 萬元 ^[1]