張笑天

2011年畢業於北京大學醫學部生物化學與分子生物學專業，獲得理學博士學位；2011至2014年北京大學博士後；2014年9月至今，在北京師範大學生命科學學院任職。主要研究方向為mRNA修飾介導的基因轉錄後調控。主持國家自然科學基金、北京市自然科學基金和北京師範大學青年教師基金等科研項目。承擔本科生《生物化學A》、《生物技術概論》和《生物技術大實驗》等課程。目前擔任2016級和2017級勵耘班輔導員。 ^[1] 

RNA修飾是表觀轉錄調控的重要方面。人們發現真核生物的mRNA和ncRNA中都存在大量的m6A和m5C修飾，這些修飾方式在轉錄後調控過程（如mRNA前體剪切、mRNA降解和翻譯等）中發揮重要作用。我們主要利用生物化學、分子生物學、細胞生物學和基因組學等研究手段， 通過體外細胞實驗和動物模型探討介導mRNA分子m5C修飾的RNA甲基轉移酶NSun2以及其他RNA結合蛋白（如HuR, TTP和AUF1等）參與轉錄後調控的分子機制和生物學功能。 ^[1] 

1. Kelei Li＊, Xiaotian Zhang＊, Gong Chen, Lijun Pei, Hailong Xiao,Jiajing Jiang, Jiaomei Li, Xiaoying Zheng, and Duo Li. Association of fatty acids and lipids metabolism in placenta with early spontaneous pregnancy loss in Chinese women. Food & Function, 2018, 9: 1179-1186.

2. Kelei, Li＊, Xiaotian Zhang＊, Lijun Pei, Gong, Chen, Jianmeng Liu, Mark L. Wahlqvist, Xiaoying Zheng, and Duo Li. High ratios of C20:4n-6/C20:5n-3 and thromboxane B2/6-Keto-Prostaglandin F1a in placenta are potential risk contributors for Neural Tube Defects: a case-control study in Shanxi Province, China. Birth defects research Part A, 2017, 109(8): 550-563.

3. Pengfei Xu, Jiao Li, Jin Liu, Jing Wang, Zekai Wu, Xiaotian Zhang＃, and Yonggong Zhai＃. Mature adipocytes observed to undergo reproliferation and polyploidy. FEBS Open Bio, 2017, 7(5):652-658.

4. Shuhong Sun＊, Xiaotian Zhang＊＃, Lin Lyu, Xixi Li, Siliang Yao, and Junjie Zhang＃. Autotaxin expression is regulated at the post-transcriptional level by the RNA-binding proteins HuR and AUF1. Journal of Biological Chemistry, 2016，219(50): 25823-36.

5. Xiaotian Zhang＊, Zhenyun Liu＊, Jie Yi, Hao Tang, Junyue Xing, Mingwei Yu, Tanjun Tong, Yongfeng Shang, Myriam Gorspe, and Wengong wang. The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3’-untranslated region of p16. Nature Communication, 2012, 3: 712. doi:10.1038/ncomms1692.

6. Fang Xu＊, Xiaotian Zhang＊, Yutao Lei, ect. Loss of repression of HuR translation by miR-16 may be responsible for the elevation of HuR in human breast carcinoma. Journal of Biological Chemistry. 2010, 11(3): 727-34.

7. Hao Tang, Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, ect. HuR regulates telomerase activity through TERC methylation. Nature Comunication, 2018, 9(1):2213. doi: 10.1038/s41467-018-04617-7

8. Shuhong Sun, Ran Wang, Jianwen Song, Ming Guan, Na Li, Xiaotian Zhang, Zhanwen Zhao, Junjie Zhang. Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity. Journal of Lipid Research, 2017, 58(11): 2102-2113.

9. Junwei Ni, Mingyang jiang, Xiaotian Zhang, Hao Tang, Hengwei Jin and ect. Post- transcriptional regulation of Nkx2.5 by RHAU in heart development. Cell Report, 2015, 13(4): 723-32. ^[1]