張春芝

工作經歷

2019.06-至今 中國農業科學院農業基因組研究所 研究員

2019.01-2019.06 中國農業科學院農業基因組研究所 助理研究員

2014.06-2019.01 中國農業科學院 博士後

2011.09–2014.07 中國農業科學院 蔬菜學 農學博士

2012.10–2014.03 瓦赫寧根大學 植物育種系 聯合培養博士

2008.09–2011.07 中國農業科學院 蔬菜學 農學碩士

2003.09–2007.07 瀋陽農業大學 生態學 理學學士

馬鈴薯是最重要的塊莖類糧食作物。與其它穀物類糧食作物不同，馬鈴薯是依靠塊莖進行無性繁殖的同源四倍體作物。受制於四倍體遺傳的複雜性，馬鈴薯的遺傳改良較慢。為了加快馬鈴薯的育種效率，降低生產成本，我們開展了“優薯計劃”（“二倍體馬鈴薯雜交育種計劃”），旨在將馬鈴薯由四倍體薯塊繁殖的作物改造成二倍體種子繁殖的作物，變革馬鈴薯的育種和繁殖方式。

圍繞“優薯計劃”主要開展以下工作：（1）二倍體馬鈴薯種質資源收集、保存、評價與創新；（2）馬鈴薯重要農藝性狀基因的挖掘；（3）馬鈴薯雜種優勢的遺傳基礎；（4）二倍體馬鈴薯基因組設計育種。

圍繞“優薯計劃”開展了一系列理論創新和育種實踐，建立了國內最大的二倍體馬鈴薯種質資源庫，通過基因組編輯的方法克服了二倍體馬鈴薯自交不親和的難題（Ye et al., Nature Plants, 2018），並解析了馬鈴薯自交衰退的遺傳基礎（Zhang et al., Nature Genetics, 2019）。在此基礎之上，已經培育出了第一代二倍體馬鈴薯自交系和第一個概念性雜交種，為“優薯計劃”的順利開展奠定了基礎。

2020年獲得國家自然科學基金委優秀青年基金資助。

To achieve the Upotato Plan, we carried out a series of theoretical innovation and breeding practices. Up to now, we have established the diploid potato genebank, overcome the self-incompatibility of diploid potato by genome editing (Ye et al., Nature Plants, 2018), and deciphered the genetic basis of inbreeding depression in potato (Zhang et al., Nature Genetics, 2019). Based on this, we have developed the first diploid potato inbred lines and the first concept potato hybrid, which provides solid foundation for Upotato Plan.

1. Chunzhi Zhang, Zhongmin Yang, Die Tang, Yanhui Zhu, Pei Wang, Dawei Li, Guangtao Zhu, Xingyao Xiong, Yi Shang, Canhui Li, Sanwen Huang*. (2021) Genome design of hybrid potato. Cell, 184: 1-11.

2.Ling Ma#, Chunzhi Zhang#, Bo Zhang#, Fei Tang, Futing Li, Qinggang Liao, Die Tang, Zhen Peng, Yuxin Jia, Meng Gao, Han Guo, Jinzhe Zhang, Xuming Luo, Huiqin Yang, Dongli Gao, William J. Lucas, Canhui Li*, Sanwen Huang*, Yi Shang*. (2021) A nonS-locusF-box gene breaks self-incompatibility in diploid potatoes. Nature Communications, 12:4142.

3. Zhongmin Yang, Shuangshuang Feng, Die Tang, Lidong Zhang, Yumei Li, Philip Kear, Sanwen Huang^*, Chunzhi Zhang^*. (2020) The mutation of a PECTATE LYASE-LIKE gene is responsible for the yellow margin phenotype in potato. Theoretical and Applied Genetics , 133: 1123-1131.

4. Zhen Peng, Pei Wang, Die Tang, Yi Shang, Canhui Li, Sanwen Huang, Chunzhi Zhang^*. (2019) Inheritance of steroidal glycoalkaloids in potato tuber flesh. Journal of Integrative Agriculture 18: 2255-2263.　

5. Chunzhi Zhang^#, Pei Wang^#, Die Tang^#, Zhongmin Yang, Fei Lu, Jianjian Qi, Nilesh R. Tawari, Yi Shang, Canhui Li, Sanwen Huang^*. (2019) The genetic basis of inbreeding depression in potato. Nature Genetics 51: 374-378.

6. Qun Lian^#, Die Tang^#, Zhiyan Bai^#, Jianjian Qi, Fei Lu, Sanwen Huang, Chunzhi Zhang^*. (2018) The acquisition of deleterious mutations during the polyploidization of potato. Journal of Integrative Plant Biology 61: 7-11.

7. Mingwang Ye^#, Zhen Peng^#, Die Tang, Zhongmin Yang, Dawei Li, Yunmei Xu, Chunzhi Zhang^*, Sanwen Huang^*. (2018) Generation of self-compatible diploid potato by knockout of S-RNase . Nature Plants 4: 651-654.

8. Dongli Gao^#, Chunzhi Zhang^#, Shu Zhang^#, Bowen Hu, Shenhao Wang, Zhonghua Zhang, Sanwen Huang^*. (2017) Mutation in a novel gene SMALL AND CORDATE LEAF 1 affects leaf morphology in cucumber. Journal of Integrative Plant Biology 59: 736-741.

9. Chunzhi Zhang^#, Lei Liu^#, Xiaoxuan Wang, Jack Vossen, Guangcun Li, Tao Li, Zheng Zheng, Jianchang Gao, Yanmei Guo, Richard G.F. Visser, Junming Li^*, Yuling Bai^*, Yongchen Du^*. (2014) The Ph-3 gene from Solanum pimpinellifolium encodes CC-NBS-LRR protein conferring resistance to Phytophthora infestans . Theoretical and Applied Genetics 127:1353-1364.

10. Chunzhi Zhang^#, Lei Liu^#, Zheng Zheng, Yuyan Sun, Longxi Zhou, Yuhong Yang, Feng Cheng, Zhonghua Zhang, Xiaowu Wang, Sanwen Huang, Bingyan Xie, Yongchen Du, Yuling Bai, Junming Li^*. (2013) Fine mapping of the Ph-3 gene conferring resistance to late blight ( Phytophthora infestans ) in tomato. Theoretical and Applied Genetics , 126:2643-2653.