- 中文名
- 张岱
- 国 籍
- 中国
- 毕业院校
- 北京医科大学
- 性 别
- 男
人物经历
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北少芝探赠整询纸想页套京脑科学与类脑研究中心，转颂旬旋化医学中心主提榜章任 [1]；北京大学第六医院（精神卫生研究所）主任医师、挨剃雅教授；北京大学-清华大学生命科学中心临床研究员，北京大只订学McGovern脑研究所研究员；兼任国家卫健委精神卫生学重点实验室主任和北京神经科学学会孤独症专业委员叠采会主任委员等职。
研究概述
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在国家863和973计划、科技支撑计划以及自然科学基金重点项目资助下，主要从事精神疾病遗传和脑影像研究。近年来，基于神经发育缺陷假说，应用遗传关联和多基因交互作用分析方法，筛选孤独症与精神分裂症易感基因，并探讨脑结构/功能异常与易感基因的相关性，进而利用基因修饰细胞和小鼠模型了解易感基因与神经发育异常的关系，从人群、细胞、动物、分子等多个层次探讨孤独症和精神分裂症神经环路发育异常的生物学基础；设计相应干预策略，寻找疾病潜在的分子靶点和治疗方法。在所从事研究方向共发表通讯作者论文100余篇，代表性论著发表在Nat Genet, PNAS, Mol Psychiatry, Am J Psychiatry, Biol Psychiatry, Cereb Cortex, Schizophr Bull, Cell Rep, NeuroImaging, Neurobiol Aging等杂志。连续5年入选Elsevier中国神经科学领域高被引学者榜单。
发表文章
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10 Selected Publications
1. Zhang Z, Ye M, Li Q, You Y, Yu H, Ma Y, Mei L, Sun X, Wang L, Yue W, Li R, Li J, Zhang D. (2019). The schizophrenia susceptibility gene OPCML regulates spine maturation and cognitive behaviors through Eph-cofilin signaling. Cell Reports. 29(1):49-61.
2. Zheng F, Yan H, Liu B, Yue W, Fan L, Liao J, Cui Y, Lu T, Jiang T, Zhang D. (2017). ALDH2 Glu504Lys Confers Susceptibility to Schizophrenia and Impacts Hippocampal-Prefrontal Functional Connectivity. Cereb Cortex. 27(3):2034-2040.
3. Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, Mei L, Lu L, Zhang C, Yue W, Xu L, Rao Y, Zhang D. (2015). Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. PNAS. 112(50):E6964-72.
4. Zhang F, Xu Y, Shugart YY, Yue W, Qi G, Yuan G, Cheng Z, Yao J, Wang J, Wang G, Cao H, Guo W, Zhou Z, Wang Z, Tian L, Jin C, Yuan J, Liu C, Zhang D. (2015). Converging Evidence Implicates the Abnormal MicroRNA System in Schizophrenia. Schizophr Bull. 41(3):728-35.
5. Yue WH, Wang HF, Sun LD, Tang FL, Liu ZH, Zhang HX, Li WQ, Zhang YL, Zhang Y, Ma CC, Du B, Wang LF, Ren YQ, Yang YF, Hu XF, Wang Y, Deng W, Tan LW, Tan YL, Chen Q, Xu GM, Yang GG, Zuo XB, Yan H, Ruan YY, Lu TL, Han X, Ma XH, Wang Y, Cai LW, Jin C, Zhang HY, Yan J, Mi WF, Yin XY, Ma WB, Liu Q, Kang L, Sun W, Pan CY, Shuang M, Yang FD, Wang CY, Yang JL, Li KQ, Ma X, Li LJ, Yu X, Li QZ, Huang X, Lv LX, Li T, Zhao GP, Huang W, Zhang XJ, Zhang D. (2011). Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet. 43(12):1228-31.
6. Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D. (2005). Positive association of the OXTR gene with autism in the Chinese Han Population. Biol Psychiatry. 58: 74-77.
7. Wang F, Sun Z, Cui LW, Du XK, Hong N, Zhang D. (2004). Anterior cingulum abnormalities in male schizophrenia with diffusion tensor imaging. Am J Psychiatry. 161:573-575.
8. Zha Q, Ruan Y, Hartmann T, Beyreuther K, Zhang D. (2004). GM1 ganglioside regulates the proteolysis of amyloid precursor protein. Mol Psychiatry. 9(10):946-52.
9. Yang J, Si T, Ruan Y, Ling Y, Han Y, Wang X, Zhou M, Zhang H, Kong Q, Liu C, Zhang D, Yu Y, Liu S, Ju G, Shu L, Ma D, Zhang D. (2003). Association study of neuregulin 1 gene with schizophrenia. Mol Psychiatry. 8: 706-709.
10. Yang J, Si T, Ling Y, Ruan Y, Han Y, Wang X, Zhang H, Kong Q, Li X, Liu C, Zhang D, Zhou M, Yu Y, Liu S, Shu L, Ma D, Wei J, Zhang D. (2003). Association study of the human FZD3 locus with schizophrenia. Biol Psychiatry. 54(11):1298-301.
