張小鬱

1983年9月至1998年7月 在原蘭州醫學院臨牀醫學系攻讀本科。

1996年9月至1999年7月 在原蘭州醫學院藥理學攻讀碩士。

2002年9月至2005年6月 在蘭大生命科學學院動物生理學攻讀博士。

1998年9月至1996年7月 在蘭拖廠醫院任主治醫師。

1999年7月至2000年6月 在原蘭州醫學院生理學教研室任助教。

2000年7月至2002年6月 在原蘭州醫學院生理學教研室任講師。

2002年7月至2004年11月 在原蘭州醫學院生理學教研室任副教授。

2004年11月至2008年5月 在蘭州大學基礎醫學院生理學研究所任副教授。

2008年5月---至今 在蘭州大學基礎醫學院生理學研究所任教授。

2008年12月至2009年12月 在美國懷俄明大學做訪問學者。

1、採用規範的細胞和分子生物學/生理學技術進行有關生理、藥理學方面的研究。

2、採用細胞信號轉導、氧化脅迫以及細胞凋亡技術對心血管疾病、糖尿病以及肥胖等進行研究。

Research Interests：

1、 Work with a major responsibility of physiology and pharmacology using standard cellular and molecular biology/physiology techniques。

2、Focus on cell signaling, oxidative stress, and apoptosis in a number of cardiovascular diseases, diabetes, and obesity。 ^[1] 

1、 2004年甘肅省醫療衞生中青年學術技術帶頭人。

2、《葡萄籽中原花青素對阿黴素增效減毒作用及機理研究》榮獲2006年甘肅省自然科學二等獎（1/5），甘肅省高校科技進步一等獎（1/8），蘭州大學優秀博士論文。

3、2007年榮獲蘭州大學度首屆“隆基中青年教師教學骨幹獎”，獲得國家留學基金委資助作為訪問學者去美國進行科學研究一年，提高科研水平。

honors and awards：

1、I won the Discipline Leader on Young and Middle-aged Science and Technology of Public Health Department of Gansu。

2、2006 Mechanisms of Proanthocyanidin from Grape Seeds in both Potentiating Anti-tumor Activity and Reducing Toxicity of Doxorubicin obtained the second prize of Gansu Provincial Natural Science, the first prize of scientific and techonology progress in Gansu Provincial advanced colleges and was entitled as the Excellence Doctor Paper in Lanzhou University. (first author)。

3、2007 I won the prize of the Longji Excellence Teacher in Lanzhou University. At the same time, I got through the academic selection。 process organized by China Scholarship Council (CSC) and was granted the funds to study abroad for a year。

1. XiaoYu ZHANG, WenGuang LI, YongJie WU, TianZhen ZHENG, Wei LI, SongYi QU and NaiFa LIU. Proanthocyanidin from grape seeds potentiates anti-tumor activity of doxorubicin via immunomodulatory mechanism. Int. Immunopharmacol. 2005; 5(7-8): 1247–1257.(SCI)

2. XiaoYu ZHANG, WenGuang LI, YongJie WU, DeCheng BAI, and NaiFa LIU. Proanthocyanidin from grape seeds enhances doxorubicin-induced anti-tumor effect andreverses drug resistance in doxorubicin-resistant K562/DOX cells. Can. J. Physiol. Pharmacol. 2005; 83(3): 309–318. (SCI)

3. XiaoYu ZHANG, WenGuang LI, YongJie WU and MingTang GAO. Amelioration of doxorubicin-induced myocardial oxidative stress and immunosuppression by grape seed proanthocyanidins in tumor-bearing mice. J. Pharmacy Pharmacol. 2005: 57(8): 1043–1052. (SCI)

4. Xiaoyu ZHANG,Decheng BAI, Yongjie WU, Wenguang LI and Naifa LIU. Proanthocyanidin from grape seeds enhances anti-tumor effect of doxorubicin both in vitro and in vivo. Pharmazie. 2005; 60(7): 533–538. (SCI)

5. XiaoYu ZHANG, WenGuang LI, YongJie WU and Xuan TIAN. Antioxidative and antitumor activity of spin labeled derivatives of 4-β-amino-4'-demethylepipodophyllotoxin and their structure-activity relationship. Pharmazie. 2007; 62(6): 432–438.(SCI)

6. WenGuang LI, XiaoYu ZHANG, YongJie WU, MingTang GAO and Rongliang ZHENG.. The relationship between structure and antioxidative activity of piperidine nitroxides. J. Pharm. Pharmacol. 2006; 58(7): 941–949.(SCI)

7. LI Wenguang,ZHANG XiaoYu, WU YongJie and TIAN Xuan. Antioxidative activity of spin labelled derivatives of podophyllilic acid hydrazide. Acta Pharmacol. Sin.2002; 23(8): 727–732. (SCI)

8. LI Wenguang,ZHANG XiaoYu, WU YongJie and TIAN Xuan. Anti-inflammatory effect and mechanism of proanthocyanidins from grape seeds. Acta Pharmacol. Sin. 2001; 22(12): 1117-1120. (SCI)

9. ZHANG XiaoYu, ZHENG TianZhen and PANG JinJiang. Effects of progesterone on contractile activity of trachea smooth muscle in rabbits. Chin J Appl Physiol. 2003; 19(4): 388, 401.

10.ZHANG XiaoYu, LI WenGuang, ZHENG TianZhen and LI　Wei. Effects of proanthocyanidins on contractile activity of aortic smooth muscle and platelet aggregation in experimental animals. Chin J Appl Physiol. 2005; 21(4): 383-386.

11. ZHANG XiaoYu, LI WenGuang, GAO MingTang and TIAN Xuan. Protectective effect on injured myocardial cells of proanthocyanidins in vitro. Pharmacol Clin Chin Materia Med. 2001; 17(6): 14-16

12. ZHANG XiaoYu, GAO MingTang, LI WenGuang, TIAN Xuan and ZHU JuHua. The anti-lipoperoxidative effect of grape seed extractin vitro. Advanced in Free Badical Life Sciences. 1999; 7: 116-120.

13. ZHANG XiaoYu, ZHANG YongPing and LI WenGuang. Anti-tumor activity of lanthanum nitrate Complexes with bis(2-pyridyl-N-Oxide)disulphide in vitro. J Lanzhou University ( Natural Sci). 2004; 40Supp: 34–36.

14. ZHANG XiaoYu, LI WenGuang, WU YongJie and GAO MingTang. CHL chromosome aberration test of proanthocyanidinsfrom grape seeds. J Lanzhou University ( Natural Sci). 2002; 38(6) Supp: 15-17.

15. Xiaoyu Zhang, Jingying Wang, Wenguang Li, Ji Li. Natural Antioxidant-Isoliquiritigenin Protects Heart against Ischemia-Reperfusion Injury via Activation of Cardioprotective Signaling Pathways. Circulation. 2009;120:S1445.(Abstract)

16. Tuanming YANG, ShiFang GUO, Changrui CHENG, XiaoYu ZHANG and Wenguang LI. Anti-osteosarcoma effects and mechanisms of 4-O-amino-phenol-4′-demethylepipodophyllotoxin ether. J. Pharm. Pharmacol. 2008；60(2): 179-188.(SCI)

17. SI JinChao, ZHANG XiaoYu, LIN MeiLing, DING YongHui, LI Mei, QU SongYi and ZHENG TianZhen. Effects of Ephedra on body mass, serum lipid, glucose and hormone level of ovarietomized obese rats. Chin J Clin Rehabilit. 2006; 10(47): 209–212.

18. LI WenGuang,ZHANG XiaoYu and WU YongJie. Effect of podophyllic acid hydrozide piperidingyloxy and its derivatives on MDA formation. Chin Pharmacol Bull. 1997; 13(5): 422-424.

19. Jingying Wang, Heng Ma, Xiaoyu Zhang, Leilei He, Jianming Wu, Xiaoping Gao, Jun Ren, Ji Li.A Novel AMPK Activator from Chinese Herb Medicine and Ischemia Phosphorylate the Cardiac Transcription Factor FOXO3. Int J Physiol Pathophysiol Physiol. 2009: 1: 116-126

20. Peng Zhao, Jingying Wang, Leilei He, Heng M, Xiaoyu Zhang, Xinglei Zhu, E. Kurt Dolence, Jun Ren, Ji Li. Deficiency in TLR4 signal transduction ameliorates cardiac injury and cardiomyocyte contractile dysfunction during ischemia.J. Cell. Mol. Med. 2009; 13: 1513–1525

21. Wang Jun, Wang Hao, Guo Zhen, ZHANG XiaoYu, QU SongYi and ZHENG TianZhen. Gastrodin in modulating body mass and metabilism in obese rats fed with high-fat diet. J Clin Rehabilit. Tissue Engineering Res. 2008; 12(207): 3992–3996.

22. Guo Jiaohong, Li Xujun, Yue Jia, ZHANG XiaoYu, Lin Meiling and ZHENG TianZhen. The effects of Radix Achykanthis Bidentatae from Henan of China on body weight and tumor Necrosis Factor-α in ovariectomized obese rats. J Chengdu Medical College 2008; 3(2): 100–102, 106.

23. Li Xujun, Yue Jia, Chang Yanqin, Lin Meiling,ZHANG XiaoYu, Ding Yonghui and ZHENG TianZhen. Effects of Rhizoma Wenyujin Concisum on ovariectomized obese rats. China J Modern Med. 2008; 18(4): 405–407, 412.

24. 袁良傑，盧霞，王君，鄭天珍，瞿頌義，張小鬱*. 苦蔘鹼對高脂肥胖大鼠體重、血脂和抗過氧化能力的影響. 時珍國醫國藥. 2008; 19（9）: 2062-2064（*為通訊作者）(CSCD)

25. 白 巖，盧伍黨，李文廣，張小鬱*. 金屬配合物Cu(Ⅱ)1-羥基-3-（2-環氧基）噸酮的體外抗腫瘤作用. 蘭州大學學報（醫學版）. 2010; 36(2): 56-60 （*為通訊作者）

26. 白 巖，盧伍黨，李文廣，張小鬱*. 金屬配合物Cu(Ⅱ)噸酮冠醚的體外抗腫瘤作用. 蘭州大學學報（醫學版）. 2010; 36(3): 21-25（*為通訊作者）

27. 黃徵，張林，瞿頌義， 鄭天珍，張小鬱*. 天麻素對大鼠離體脂肪組織釋放遊離脂肪酸及抗氧化作用的影響. 第四軍醫大學學報(J. Fourth Mil. Univ.). 2009：30（16）：1488-1490. （*為通訊作者）(CSCD)