孫寶發

多維組學解析腫瘤、免疫及發育等功能調控。

1. 通過單細胞及空間轉錄組揭示腫瘤發生、轉移、耐藥、免疫等分子機理。

2. 揭示表觀基因組及表觀轉錄組學在各種疾病及生物學過程的調控作用。

3. 闡明RNA結合蛋白及RNA加工在各種生理及病理調控中的作用。

4. 明確相分離在腫瘤及免疫調控中的作用機理。

承擔科研項目情況： ^[1] 

1.國家基金委面上項目，m5C 調控 mRNA 翻譯的功能研究， 2017/01-2020/12，在研，主持；

2.中科院人才項目，2016級青年創新促進會，2016/01-2019/12，在研，主持；

3.國家基金委青年科學基金項目，RNA mA甲基化修飾調控mRNA選擇性剪接機制研究，2015/01-2017/12，結題，主持；

4.國家基金委重大研究計劃，可逆化學修飾調控 lncRNA二級結構機制及其功能研究，2018/01-2021/12，在研，參加；

5.國家基金委重點項目，RNA mA 修飾甲基轉移酶複合物及其表觀調控因子鑑定和作用機制研究，2015.01-2019.12，在研，參加；

代表性論文： ^[1] 

通訊作者以“*”標出，第一作者以“#”：

(1) Chunxia Zhang#, Yusheng Chen#, Baofa Sun#, Lu Wang#, Ying Yang#, Dongyuan Ma, Junhua Lv, Jian Heng, Yanyan Ding, Yuanyuan Xue, Xinyan Lu, Wen Xiao, Yun-Gui Yang*, Feng Liu*. m⁶A modulates haematopoietic stem and progenitor cell specification. Nature 549(7671): 273-276 (2017) （入選2017年中國生命科學研究領域十大進展）

(2) Xin Chen#, Ang Li#, Bao-Fa Sun#, Ying Yang#, Ya-Nan Han#, Xun Yuan#, Ri-Xin Chen, Wen-Su Wei, Yanchao Liu, Chun-Chun Gao, Yu-Sheng Chen, Mengmeng Zhang, Xiao-Dan Ma, Zhuo-Wei Liu, Jun-Hang Luo, Cong Lyu, Hai-Lin Wang, Jinbiao Ma, Yong-Liang Zhao, Fang-Jian Zhou, Ying Huang*, Dan Xie*, Yun-Gui Yang*. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs. Nature Cell Biology 21(8): 978–990 (2019)

(3) Jun-Ya Peng#, Bao-Fa Sun#, Chuan-Yuan Chen#, Jia-Yi Zhou#, Yu-Sheng Chen#, Hao Chen, Lulu Liu, Dan Huang, Jialin Jiang, Guan-Shen Cui, Ying Yang, Wenze Wang, Dan Guo, Menghua Dai, Junchao Guo, Taiping Zhang, Quan Liao, Yi Liu, Yong-Liang Zhao, Da-Li Han#, Yupei Zhao*, Yun-Gui Yang*, Wenming Wu*. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma. Cell Research 29(9): 725-738 (2019)

(4) Yaqian Li#, Qing-Yang Zhang#, Bao-Fa Sun#, Yidi Ma , Ye Zhang , Min Wang , Congcong Ma , Honghui Shi , Zhijing Sun , Juan Chen , Yun-Gui Yang*, Lan Zhu* . Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse, Nature Communications 12(1): 87 (2021).

(5) Shiming Peng#, Wen Xiao#, Dapeng Ju#, Baofa Sun#, Nannan Hou, Qianlan Liu, Yanli Wang, Haijiao Zhao, Chunchun Gao, Song Zhang, Ran Cao, Pengfei Li, Huanwei Huang, Yongfen Ma, Yankai Wang, Weiyi Lai, Zhixiong Ma, Wei Zhang, Song Huang, Hailin Wang, Zhiyuan Zhang, Liping Zhao, Tao Cai, Yong-Liang Zhao, Fengchao Wang, Yongzhan Nie, Gang Zhi, Yun-Gui Yang*, Eric Erquan Zhang*, Niu Huang*. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Science Translational Medicine 11(488): eaau7116 (2019)

(6) Rong Wu#, Ang Li#, Baofa Sun#, Jian-Guang Sun#, Jinhua Zhang#, Ting Zhang#, Yusheng Chen, Yujie Xiao, Yuhao Gao, Qingyang Zhang, Jun Ma, Xin Yang, Yajin Liao, Wei-Yi Lai, Xiaolong Qi, Shukun Wang, Yousheng Shu, Hai-Lin Wang, Fengchao Wang*, Yun-Gui Yang*, Zengqiang Yuan*. A novel m⁶A reader Prrc2a controls oligodendroglial specification and myelination. Cell Research 29(1): 23-41（2019）

(7) Baofa Sun#, Rui-Wu Wang*. Foundress numbers and the timing of selective events during interactions between figs and fig wasps.Scientific Reports 9(1): 3420（2019）

(8) Xin Tian#, Baofa Sun#, Chuanyuan Chen#, Chunchun Gao#, Ji Zhang#, Xingyu Lu#, Linchen Wang, Xiangnan Li, Yurong Xing, Rujuan Liu, Xiao Han, Zheng Qi, Xiaojian Zhang, Chuan He, Dali Han*, Yun-Gui Yang*, Quancheng Kan*. Circulating Tumor DNA-hydroxymethylcytosine as novel diagnostic biomarkers for esophageal cancer. Cell Research 28(5): 597-600 (2018)

(9) Xinxia Wang#, Baofa Sun#, Qin Jiang#, Ruifan Wu#, Min Cai, Yongxi Yao, Qing Liu, Hailing Shi, Jie Feng, Yizhen Wang*. mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes. International Journal of Obesity 42(11): 1912-1924 (2018).

(10) Ji Zhang#, Xiao Han#, Chunchun Gao#, Yurong Xing#, Zheng Qi, Ruijuan Liu, Yueqin Wang, Xiaojian Zhang, Yun-Gui Yang, Xiangnan Li*, Baofa Sun*, Xin Tian*. 5-hydroxymethylome in circulating cell-free DNA as a potential biomarker for non-small-cell lung cancer. Genomics Proteomics Bioinformatics 16(3): 187-199 (2018)

(11) Xin Yang#, Ying Yang#, Bao-Fa Sun#, Yu-Sheng Chen#, Jia-Wei Xu#, Wei-Yi Lai#, Ang Li, Xing Wang, Devi Prasad Bhattarai, Wen Xiao, Hui-Ying Sun, Qin Zhu, Hai-Li Ma, Samir Adhikari, Min Sun, Ya-Juan Hao, Bing Zhang, Chun-Min Huang, Niu Huang, Gui-Bin Jiang, Yong-Liang Zhao, Hai-Lin Wang*, Ying-Pu Sun* and Yun-Gui Yang*. 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m⁵C reader. Cell Research 27(5): 606-625 (2017) (入選Cell Research封面故事)，Cell Research和Natl Sci Rev研究特色論文評論，F1000，2017 年 Sanofi-Cell Research優秀研究文章獎、第三屆中國科協優秀科技論文.

(12) Ang Li#, Yu-Sheng Chen#, Xiao-Li Ping, Xin Yang, Wen Xiao, Ying Yang, Hui-Ying Sun, Qin Zhu, Poonam Baidya, Xing Wang, Devi Prasad Bhattarai, Yong-Liang Zhao, Bao-Fa Sun*, Yun-Gui Yang*. Cytoplasmic m⁶A reader YTHDF3 promotes mRNA translation. Cell Research 27(3): 444-447 (2017).

(13) Kai Xu#, Ying Yang#, Gui-Hai Feng#, Bao-Fa Sun#, Jun-Qing Chen#, Yu-Fei Li, Yu-Sheng Chen, Xin-Xin Zhang, Chen-Xin Wang, Li-Yuan Jiang, Chao Liu, Ze-Yu Zhang, Xiu-Jie Wang, Qi Zhou*, Yun-Gui Yang*, Wei Li*. Mettl3-mediated m⁶A regulates spermatogonial differentiation and meiosis initiation. Cell Research 27(9): 1100-1114 (2017) (封面故事)

(14) Wen Xiao#, Samir Adhikari#, Ujwal Dahal#, Yu-Sheng Chen#, Ya-Juan Hao#, Bao-Fa Sun#, Hui-Ying Sun, Ang Li, Xiao-Li Ping, Wei-Yi Lai, Xing Wang, Hai-Li Ma, Chun-Min Huang, Ying Yang, Niu Huang, Guibin Jiang, Hai-Lin Wang, Qi Zhou, Xiu-Jie Wang, Yong-Liang Zhao, Yun-Gui Yang*. Nuclear m⁶A reader YTHDC1 regulates mRNA splicing. Molecular Cell 61(4): 507-519 (2016) (入選Trends In Genetics研究熱點 )

(15) Yixin Zhang#, Na Li, Li Wang, Huiying Sun, Minyue Ma, Hui Wang, Xiaofei Xu, Wenke Zhang, Yingyu Liu, David S. Cram, Baofa Sun*, Yuanqing Yao*.Molecular analysis of DNA in blastocoele fluid using next-generation sequencing. Journal of Assisted Reproduction and Genetics 33(5): 637-645 (2016).

(16) Baofa Sun#, Tong Li#, Jinhua Xiao, Li Liu, Peng Zhang, Robert W. Murphy, Shunmin He, Dawei Huang*. Contribution of multiple inter-kingdom horizontal gene transfers to evolution and adaptation of amphibian-killing chytrid, Batrachochytrium dendrobatidis. Frontiers in Microbiology 7: 1360 (2016).

(17) Ying Yang#, Bao-Fa Sun#, Wen Xiao, Xin Yang, Hui-Ying Sun, Yong-Liang Zhao, Yun-Gui Yang*. Dynamic m⁶A modification and its emerging regulatory role in mRNA splicing. Science Bulletin 60(1): 21-32 (2015).

(18) Bao-Fa Sun#, Yong-Xing Li#, Ling-Yi Jia, Li-Hua Niu, Robert W. Murphy, Peng Zhang, Shunmin He*, Da-Wei Huang*. Regulation of transcription factors on sexual dimorphism of fig wasps. Scientific Reports 5, 10696 (2015).

(19) Bao-Fa Sun#, Tong Li#, Jin-Hua Xiao, Ling-Yi Jia, Li Liu, Peng Zhang, Robert W. Murphy, Shun-Min He, Da-Wei Huang*. Horizontal functional gene transfer from bacteria to fishes. Scientific Reports 5: 18676 (2015).

(20) Xiao-Li Ping#, Bao-Fa Sun#, Lu Wang#, Wen Xiao#, Xin Yang, Wen-Jia Wang, Samir Adhikari, Yue Shi, Ying Lv, Yu-Sheng Chen, Xu Zhao, Ang Li, Ying Yang, Ujwal Dahal, Xiao-Min Lou, Xi Liu, Jun Huang, Wei-Ping Yuan, Xiao-Fan Zhu, Tao Cheng, Yong-Liang Zhao, Xinquan Wang, Jannie M Rendtlew Danielsen, Feng Liu*, Yun-Gui Yang*. Mammalian WTAP is a regulatory subunit of the RNA N⁶-methyladenosine methyltransferase. Cell Research 24(2): 177-189 (2014) (入選Natl Sci Rev研究特色論文評論)

(21) Xu Zhao#, Ying Yang#, Bao-Fa Sun#, Yue Shi#, Xin Yang, Wen Xiao, Ya-Juan Hao, Xiao-Li Ping, Yu-Sheng Chen, Wen-Jia Wang, Kang-Xuan Jin, Xing Wang, Chun-Min Huang, Yu Fu, Xiao-Meng Ge, Shu-Hui Song, Hyun Seok Jeong, Hiroyuki Yanagisawa, Yamei Niu, Gui-Fang Jia, Wei Wu, Wei-Min Tong, Akimitsu Okamoto, Chuan He, Jannie M Rendtlew Danielsen, Xiu-Jie Wang, Yun-Gui Yang*. FTO-dependent demethylation of N⁶-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Research 24(12): 1403-1419 (2014) （入選Cell Research研究特色論文評論）

(22) Bao-Fa Sun, Jin-Hua Xiao, Shun-Min He, Li Liu, Da-Wei Huang*. Multiple horizontal gene transfers and duplications in lepidopteran species. Insect Molecular Biology 22(1): 72-87 (2013).

(23) Bao-Fa Sun, Jin-Hua Xiao, Shun-Min He, Li Liu, Da-Wei Huang*. Multiple interkingdom horizontal gene transfers in Pyrenophora and closely related species and their contributions to phytopathogenic lifestyles. PLoS ONE 8(3): e60029 (2013).

(24) Weinan Qiu#, Qingyang Zhang#, Rui Zhang, Yangxu Lu, Xin Wang, Huabin Tian, Ying Yang, Zijuan Gu, Yanan Gao, Xin Yang, Guanshen Cui, Baofa Sun, Yanan Peng, Hongyu Deng, Hua Peng, Angang Yang, Yun-Gui Yang*, Pengyuan Yang*. N⁶-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA. Nature Communications 12(1):1582 (2021).

(25) Yongyan Tang#, Chun-Chun Gao#, Ying Gao, Ying Yang, Boyang Shi, Jia-Li Yu, Cong Lyu, Bao-Fa Sun, Hai-Lin Wang, Yunyuan Xu, Yun-Gui Yang*, Kang Chong*.OsNSUN2-Mediated 5-Methylcytosine mRNA modification enhances rice adaptation to high temperature. Developmental Cell 53(3):272-286 (2020).

(26) Boyang Shi#, Jinsong Zhang#, Jian Heng#, Jing Gong#, Ting Zhang, Pan Li, Bao-Fa Sun, Ying Yang, Ning Zhang, Yong-Liang Zhao, Hai-Lin Wang, Feng Liu*, Qiangfeng Cliff Zhang*, Yun-Gui Yang*. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome Biology 21(1):120 (2020).

(27) Yuhuan Li#, Qingyang Zhang#, Guanshen Cui, Fang Zhao, Xin Tian, Bao-Fa Sun, Ying Yang*, Wei Li*.m⁶A regulates liver metabolic disorders and hepatogenous diabetes. Genomics Proteomics Bioinformatics S1672-0229(20)30129-7 (2020).

(28) Xiao Han#, Hanchen Liu#, Zezhong Zhang#, Wenlan Yang, Chunyan Wu, Xueying Liu, Fang Zhang, Baofa Sun, Yongliang Zhao, Guibin Jiang, Yun-Gui Yang*, Wenjun Ding*.Epitranscriptomic 5-Methylcytosine profile in PM_2.5-induced mouse pulmonary fibrosis. Genomics Proteomics Bioinformatics 18(1):41-51 (2020).

(29) Ying Yang#, Lu Wang#, Xiao Han#, Wen-Lan Yang#, Mengmeng Zhang#, Hai-Li Ma, Bao-Fa Sun, Ang Li, Jun Xia, Jing Chen, Jian Heng, Baixing Wu, Yu-Sheng Chen, Jia-Wei Xu, Xin Yang, Huan Yao, Jiawei Sun, Cong Lyu, Hai-Lin Wang, Ying Huang, Ying-Pu Sun, Yong-Liang Zhao, Anming Meng, Jinbiao Ma*, Feng Liu*, Yun-Gui Yang*.RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay. Molecular Cell 75(6):1188-1202 (2019).

(30) Lionel Malbec#, Ting Zhang#, Yu-Sheng Chen#, Ying Zhang, Bao-Fa Sun, Bo-Yang Shi, Yong-Liang Zhao, Ying Yang*, Yun-Gui Yang*.Dynamic methylome of internal mRNA N⁷-methylguanosine and its regulatory role in translation. Cell Research 29(11):927-941 (2019).

(31) Ruobing Jia#, Peiwei Chai#, Shanzheng Wang#, Baofa Sun, Yangfan Xu, Ying Yang, Shengfang Ge, Renbing Jia*, Yun-Gui Yang*, Xianqun Fan*.m⁶A modification suppresses ocular melanoma through modulating HINT2 mRNA translation. Molecular Cancer 18(1):161 (2019).

(32) Lichao Liu#, Tong Li#, Guang Song#, Qingxia He, Yafei Yin, J Yuyang Lu, Xianju Bi, Kaili Wang, Sai Luo, Yu-Sheng Chen, Ying Yang, Bao-Fa Sun, Yun-Gui Yang, Jiawei Wu, Heng Zhu*, Xiaohua Shen*.Insight into novel RNA-binding activities via large-scale analysis of lncRNA-bound proteome and IDH1-bound transcriptome. Nucleic Acids Reserch 47(5):2244-2262 (2019).

(33) Junchen Chen#, Yi-Chang Zhang#, Chunmin Huang#, Hui Shen, Baofa Sun, Xuejun Cheng, Yu-Jie Zhang, Yun-Gui Yang, Qiang Shu*, Ying Yang*, Xuekun Li*.m⁶A regulates neurogenesis and neuronal development by modulating histone methyltransferase Ezh2. Genomics Proteomics Bioinformatics 17(2):154-168 (2019).

(34) Zhan Shi#, Qingyang Zhang#, Huige Yan#, Ying Yang#, Pingzhang Wang, Yixiao Zhang, Zhenling Deng, Meng Yu, Wenjing Zhou, Qianqian Wang, Xi Yang, Xiaoning Mo, Chi Zhang, Jing Huang, Hui Dai, Baofa Sun, Yongliang Zhao, Liang Zhang, Yun-Gui Yang*, Xiaoyan Qiu*. More than one antibody of individual B cells revealed by single-cell immune profiling. Cell Discovery 5:64 (2019).

(35) Qin Jiang, Baofa Sun, Qing Liu, Min Cai, Ruifan Wu, Fengqin Wang, Yongxi Yao, Yizhen Wang, Xinxia Wang*.MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m6A-YTHDF1-dependent mechanism. FASEB Journal 33(2):2971-2981 (2019).

(36) Yu-Sheng Chen, Hai-Li Ma, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Yun-Gui Yang*.5-Methylcytosine analysis by RNA-BisSeq. Methods in Molecular Biology 1870:237-248 (2019).

(37) Xiao-Wei Zhang, Derek W Dunn*, Xiao-Lan Wen, Bao-Fa Sun, Rui-Wu Wang.Differential deployment of sanctioning mechanisms by male and female host trees in a gynodioecious fig-wasp mutualism. Ecology 100(3):e02597 (2019).

(38) Chen-Xin Wang#, Guan-Shen Cui#, Xiuying Liu#, Kai Xu#, Meng Wang#, Xin-Xin Zhang, Li-Yuan Jiang, Ang Li, Ying Yang, Wei-Yi Lai, Bao-Fa Sun, Gui-Bin Jiang, Hai-Lin Wang, Wei-Min Tong, Wei Li, Xiu-Jie Wang*, Yun-Gui Yang*, Qi Zhou*.METTL3-mediated m⁶A modification is required for cerebellar development. PLoS Biology 16(6):e2004880 (2018).

(39) Peng Zhang#, Chunli Pei#, Xi Wang, Jinyi Xiang, Bao-Fa Sun, Yongsheng Cheng, Xiaolong Qi, Marco Marchetti, Jia-Wei Xu, Ying-Pu Sun, Bruce A Edgar*, Zengqiang Yuan*.A balance of Yki/Sd activator and E2F1/Sd repressor complexes controls cell survival and affects organ size. Developmental Cell 43(5):603-617 (2017).

(40) Ru Zheng#, Yue Li#, Huiying Sun#, Xiaoyin Lu, Bao-Fa Sun, Rui Wang, Lina Cui, Cheng Zhu, Hai-Yan Lin, Hongmei Wang.Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion. Reproduction 153:35-48 (2017).

(41) Guan Hong Wan*,Bao Fa Sun, Tuan Lin Xiong, Yan Kun Wang, Kristen E. Murfin, Jin Hua Xiao*, Da Wei Huang*. Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes. Frontiers in Microbiology 7:1867 (2016).

(42) Dong-Ya Cui#, Xu-Bin Sun#, Jia-Jia Wang, Peng Zhang,Bao-Fa Sun, Xiao-Wei Chen, Robert W. Murphy, Shun-Min He*, Da-Wei Huang*. Research on co-expression genes of a fig wasp.Progress in Biochemistry and Biophysics43(1): 83-89 (2016).

(43) Rui-Wu Wang, Bao-Fa Sun, Jun-Zhou He, Derek W Dunn. Non-quantitative adjustment of offspring sex ratios in pollinating fig wasps. Scientific Reports 5:13057 (2015).

(44) Rui-Wu Wang, Bao-Fa Sun, Yan Yang.Discriminative host sanction together with relatedness promote the cooperation in fig/fig wasp mutualism. TheJournal of Animal Ecology 84(4):1133-1139 (2015).

(45) Xiu-Xia Wang, Bao-Fa Sun, Jiao Jiao, Ze-Chen Chong, Yu-Shen Chen, Xiao-Li Wang, Yue Zhao, Yi-Ming Zhou, Da Li. Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia. Oncotarget 6(9):6535-6543 (2015).

(46) Tangliang Li, Yue Shi, Pei Wang, Luis Miguel Guachalla, Baofa Sun, Tjard Joerss, Yu-Sheng Chen, Marco Groth, Anja Krueger, Matthias Platzer, Yun-Gui Yang, Karl Lenhard Rudolph, Zhao-Qi Wang.Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. The EMBO Journal 34(12):1630-47 (2015).

(47) Bailin Zhao#, Ying Yang#, Xiaoli Wang#, Zechen Chong, Ruichuan Yin, Shu-Hui Song, Chao Zhao, Cuiping Li, Hua Huang, Bao-Fa Sun, Danni Wu, Kang-Xuan Jin, Maoyong Song, Ben-Zhan Zhu, Guibin Jiang, Jannie M. Rendtlew Danielsen, Guo-Liang Xu, Yun-Gui Yang*, Hailin Wang*. Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism. Nucleic Acids Research 42(3):1593-1605 (2014).

(48) Xu Zhao#, Ying Yang#, Bao-Fa Sun, Yong-Liang Zhao, Yun-Gui Yang*. FTO and obesity: mechanisms of association. Current Diabetes Reports 14(5):486 (2014).

(49) Peng Zhang#, Xiaohui Si#, Geir Skogerbo, Jiajia Wang, Dongya Cui, Yongxing Li, Xubin Sun, Li Liu, Baofa Sun, Runsheng Chen*, Shunmin He*, Da-Wei Huang*. piRBase: a web resource assisting piRNA functional study. Database (Oxford). 2014: bau110 (2014).

(50) Rui-Wu Wang, Derek W Dunn, Bao Fa Sun. Discriminative host sanctions in a fig-wasp mutualism. Ecology 95(5):1384-93 (2014).

(51) Jin-Hua Xiao#, Zhen Yue#, Ling-Yi Jia#, Xin-Hua Yang#, Li-Hua Niu#, Zhuo Wang#, Peng Zhang#,Bao-Fa Sun, Shun-Min He, Zi Li, Tuan-Lin Xiong, Wen Xin5, Hai-Feng Gu, Bo Wang, John H Werren, Robert W Murphy, David Wheeler, Li-Ming Niu, Guang-Chang Ma, Ting Tang, Sheng-Nan Bian, Ning-Xin Wang, Chun-Yan Yang, Nan Wang, Yue-Guan Fu, Wen-Zhu Li, Soojin V Yi, Xing-Yu Yang, Qing Zhou, Chang-Xin Lu, Chun-Yan Xu3, Li-Juan He, Li-Li Yu, Ming Chen, Yuan Zheng, Shao-Wei Wang, Shuang Zhao, Yan-Hong Li, Yang-Yang Yu, Xiao-Ju Qian, Yue Cai, Lian-Le Bian, Shu Zhang, Jun-Yi Wang, Ye Yin, Hui Xiao, Guan-Hong Wang, Hui Yu, Wen-Shan Wu, James M Cook*, Jun Wang* and Da-Wei Huang* Obligate mutualism within a host drives the extreme specialization of a fig wasp genome.Genome Biology14:R141 (2013).

(52) Rui-Wu Wang, Bao-Fa Sun, Qi Zheng, Lei Shi, Lixing Zhu.Asymmetric interaction and indeterminate fitness correlation between cooperative partners in the fig-fig wasp mutualism. Journal of the Royal Society Interface 8(63):1487-1496 (2011).

(53) Rui-Wu Wang, Bao-Fa Sun, Qi Zheng.Diffusive coevolution and mutualism maintenance mechanisms in a fig-fig wasp system. Ecology 91(5):1308-16 (2010).

(54) Rui-Wu Wang, Jo Ridley, Bao-Fa Sun, Qi Zheng, Derek W Dunn, James Cook, Lei Shi, Ya-Ping Zhang, Douglas W Yu.Interference competition and high temperatures reduce the virulence of fig wasps and stabilize a fig-wasp mutualism. PLoS One 4(11): e7802 (2009).

(55) Rui-Wu Wang, Bao-Fa Sun. Seasonal change in the structure of fig-wasp community and its implication for conservation. Symbiosis 47(2):77-83 (2009).

2018 發表在Nature雜誌的“m⁶A modulates haematopoietic stem and progenitor cell specification”一文被評為2017年度“中國生命科學研究領域十大進展”。

2018 發表在Cell Research上的題為“5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m⁵C reader”的文章獲得了2017年賽諾菲-Cell Research傑出研究文章獎。

2018 “5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m⁵C reader”和“Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase”被選為第三屆中國科協優秀科技論文。