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孫寧

（復旦大學基礎醫學院）

鎖定
孫寧，男，復旦大學基礎醫學院生理與病理生理學系，副主任，研究員，博士生導師。 [1] 
中文名
孫寧
國    籍
中國
民    族
漢族
職    務
復旦大學基礎醫學院生理與病理生理學系副主任

目錄

  1. 1 人物經歷
  2. ▪ 受教育經歷
  3. ▪ 工作經歷
  4. ▪ 學術任職
  5. 2 主要學術論文

孫寧人物經歷

2014年“國家自然科學基金-優秀青年科學基金”及2017年上海市“優秀學術帶頭人計劃”。主要研究多能幹細胞生物學，分子心臟醫學和心血管疾病機制及器官間對話的分子機制等中西醫結合研究。在斯坦福大學留學期間率先建立了脂肪幹細胞重編程為誘導多能幹細胞的新方法 (PNAS, 2009, 引用: 585次)。首次建立了人類家族遺傳性擴張型心肌病誘導多能幹細胞的模型並進行了疾病新機制的研究 (Science Translational Medicine, 2012，引用: 507次)。回國後建立了人類誘導多能幹細胞分化來源的心室肌細胞的純化新技術，製備了可用於移植的人造人類心室肌組織，拓展了生物新材料治療人類心肌梗塞的應用研究 (Biomaterials, 2016，Nature Biomedical Engineering 2019)；開拓了家族遺傳性心肌病基因治療的臨牀前轉化研究等。已發表包括Nature Biomedical Engineering, Science Translational Medicine, Nature Methods, Cell Stem Cell等雜誌在內的SCI論文50餘篇，論文被引用2000餘次，申請美國專利兩項，中國專利三項。 [1] 

孫寧受教育經歷

2002/08 - 2008/08，美國愛荷華州立大學，分子細胞發育生物學系，博士
1995/09 - 2000/06，復旦大學，醫學院臨牀醫學專業，學士 [1] 

孫寧工作經歷

2017/03至今，復旦大學，中西醫結合研究院，標準化研究所，副所長
2013/03至今，復旦大學，基礎醫學院生理與病理生理學系，副主任，研究員
2008/07 - 2013/02，美國斯坦福大學，醫學院醫學系，博士後
2000/07 - 2002/06，復旦大學，醫學院病理生理學系，研究助理 [1] 

孫寧學術任職

  1. 中國病理生理學會理事
  2. 中國微循環協會理事
  3. 中國生物物理學會理事
  4. 安徽省幹細胞臨牀研究專家委員會特邀顧問
  5. 上海市病理生理學會理事
  6. 上海市生理學會理事

孫寧主要學術論文

1. Li E, Li X, Huang J, Xu C, Liang Q, Ren K, Bai A, Lu C*, Qian R*, Sun N*. BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy. Protein Cell, 2020, Accepted.
2. Yufan Zheng#, Baiping Cui#, Wenrui Sun, Sining Wang, Xu Huang, Han Gao, Fei Gao, Yanpeng An, Xiaobo Li*, Ning Sun*. Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury. International Journal of Biological Science, 2020,16(7):1166-79.
3. Lin X, Liu Y, Bai A, Cai H, Bai Y, Jiang W, Yang H, Wang X, Yang L*, Sun N*, Gao H*. A viscoelastic adhesive epicardial patch for treating myocardial infarction. Nature Biomedical Engineering, 2019, 3(8):632-643. (同行評論)
4. Cui B, Zheng Y, Sun N*. Repair of Adult Mammalian Heart after Damages by Oral Intake of Gu Ben Pei Yuan San. Frontiers in Physiology, 2019, May 22; 10:607.
5. Yang H, Wei L, Liu C, Zhong W, Li B, Chen, Han R, Zhuang J, Qu JX, Tao H, Chen H, Wang W*, Sun N*. Engineering Human Ventricular Heart Tissues Based on Macroporous Iron Oxide Scaffolds. Acta Biomaterialia, 2019, 88:540-553.
6. Cui B, Zheng Y, Sun L, Shi T, Shi Z, Wang L, Huang G*, Sun N*. Heart Regeneration in Adult Mammals after Myocardial Damage. Acta Cardiologica Sinica, 2018, 34(2): 115-123.
7. Zhan Y, Sun X, Li B, Cai H, Xu C, Liang Q, Lu C, Qian R, Chen S, Yin L, Sheng W, Huang G, Sun A*, Ge J*, Sun N*. Establishment of a PRKAG2 Cardiac Syndrome Disease Model and Mechanism Study Using Human Induced Pluripotent Stem Cells. J Mol Cell Cardiol. 2018, 13(117):49-61.
8. Li B, Yang H, Wang X, Zhan Y, Sheng W, Cai H, Xin H, Liang Q, Zhou P, Lu C, Qian R, Chen S, Yang P, Zhang J, Shou W, Huang G*, Liang P*, Sun N*. Engineering human ventricular heart muscles based on a highly efficient system for purification of human pluripotent stem cell-derived ventricular cardiomyocytes. Stem Cells Res Ther, 2017, 8(1):202.
9. Wang Q, Yang H, Bai A, Jiang W, Li X, Wang X, Mao Y, Lu C, Qian R, Guo F, Ding T, Chen H, Chen S, Zhang J, Liu C, Sun N*. Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction. Biomaterials, 2016, 105: 52-65
10. Chao Lu, Yang Yang, Ran Zhao, Bingxuan Hua, Chen Xu, Zuoqin Yan, Ning Sun*, Ruizhe Qian*. Role of Circadian gene Clock during Differentiation of Mouse Pluripotent Stem Cells. Protein & Cell. 2016, 7:820-32.封面文章（Cover Article）
11. Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, Yin L, Qian R, Chen S, Ling Z, Sun N*. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein & Cell. 6:553-61,2015.
12. Zhao Q, Cai H, Zhan Y, Li B, Sun N*. Applications of Human Induced Pluripotent Stem Cells in the Investigation of Inherited Cardiomyopathy. Int J Cardiol. 15;177(2):604-6, 2014.
13. Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC*. Patient-Specific Induced Pluripotent Stem Cell as A Model for Familial Dilated Cardiomyopathy. Science Translational Medicine. 4(130): 130ra47, 2012. 封面文章（Cover Article）
14. Liu J#, Sun N#, Bruce MA, Wu JC, Butte MJ*. Atomic Force Mechanobiology of Pluripotent Stem Cell-Derived Cardiomyocytes. Plos ONE. 7(5): e37559, 2012. #共同第一作者(Co-first Author)
15. Sun N, Longaker MT, Wu JC*. Human iPS Cell-Based Therapy: Considerations before clinical applications. Cell Cycle. 9(5): 1-6, 2010.
16. Sun N, T.W. Huiatt, Z. Li, D. Paulin, R.M. Robson*. Human synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration. Exp Cell Res. 316(3): 491-505, 2010. 重點突出文章(Highlighted Article)
17. Sun N, Lee A, Wu JC*. Long term non-invasive imaging of embryonic stem cells using reporter genes. Nature Protocols. 4(8): 1192-1201, 2009.
18. Sun N, Panetta NJ, Gupta DM, Wilson KD, Lee A, Jia F, Hu S, Cherry AM, Robbins RC, Longaker MT, Wu JC*. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A. 106(37): 15720-15725, 2009.
19. Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Human Alpha-Synemin Interacts Directly with Vinculin and Metavinculin. Biochem J. 409: 657-667, 2008. 獲同行評價 (Editorial Commentary)
20. Sun N, Critchley DR, Li Z, Paulin D, Robson RM*. Identification of a Repeated Domain within Mammalian Alpha-Synemin that Interacts Directly with Talin. Exp Cell Res. 314: 1839-1849, 2008.
21. Yuan G, Hua B, Cai T, Li E, Huang Y, Sun N, Yan Z, Lu C, Qian R. Clock mediates liver senescence by controlling ER stress. Aging 2017, 9:2647-2665
22. Zhu, Z., Hua, B., Shang, Z., Yuan, G., Xu, L., Li, E., Li, X., Sun, N., Yan, Z., Qian, R., and Lu, C. Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition. BioMed research international 2016, 5438589
23. Zhu, Z., Hua, B., Xu, L., Yuan, G., Li, E., Li, X., Sun, N., Yan, Z., Lu, C., and Qian, R. CLOCK promotes 3T3-L1 cell proliferation via Wnt signaling. IUBMB life 2016, 68:557-568
24. Song Y, Zhang C, Zhang J, Sun N, Huang K, Li H, Wang Z, Huang K, Wang L. An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction. Acta Biomater. 2016, 41:210-23.
25.Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D. Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. Circ Res. 117(4):364-75, 2015.
26. Wang L, Xu C, Zhu Y, Yu Y, Sun N, Zhang X, Feng K, Qin J. Human induced pluripotent stem cell-derived beating cardiac tissues on paper. Lab on a Chip. 15:4283-90, 2015.
27. Wang L, Chen B, Wang Y, Sun N, Lu C, Qian R, Hua L. hClock gene expression in human colorectal carcinoma. Mol Med Rep. 8(4):1017-22, 2013.
28. Gao Y, Meng D, Sun N, Zhu Z, Zhao R, Lu C, Chen S, Hua L, Qian R. Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells. Biochem Biophys Res Commun.443(2):586-91, 2014.
29. Wang Y, Qian R, Sun N, Lu C, Chen Z, Hua L.Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo. Mol Med Rep. 11(6):4204-10, 2015.
30. Narsinh HK, Sun N, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Wu JC*. Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Journal of Clinical Investigation. 121(3): 1217-21, 2011.
31. Wilson KD, Sun N, Huang M, Zhang WY, Lee AS, Li Z, Wang SX, Wu JC*. Effects of ionization on self-renewal and pluripotency of human embryonic stem cells. Cancer Res. 70 (13): 5539-48, 2010.
32. Zhao H, Sun N, Young SR, Nolley R, Santos J, Wu JC, Peehl DM*. Induced pluripotency of human prostatic epithelial cells. PLoS One. 22;8(5):e64503, 2013.
33. Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, Longaker MT, Wu JC*. A nonviral minicircle vector for deriving human iPS cells. Nature Methods. 7 (3): 197-9, 2010.
34. Wang Y, Zhang WY, Hu S, Lan F, Lee AS, Huber B, Lisowski L, Liang P, Huang M, de Almeida PE, Won JH, Sun N, Robbins RC, Kay MA, Urnov FD, Wu JC*. Genome Editing of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells with Zinc Finger Nuclease for Cellular Imaging. Circ Res. 111:1494-1503, 2012.
35. Taylor RE, Kim K, Sun N, Park SJ, Sim JY, Fajardo G, Bernstein D, Wu JC, Pruitt BL*. Sacrificial layer technique for axial force post assay of immature cardiomyocytes. Biomedical Microdevices. 2012 Sep 25.
36. Levi B, Hyun JS, Montoro DT, Lo DD, Chan CK, Hu S, Sun N, Lee M, Grova M, Connolly AJ, Wu JC, Gurtner GC, Weissman IL, Wan DC, Longaker MT*. In vivo directed differentiation of pluripotent stem cells for skeletal regeneration. Proc. Natl. Acad. Sci. U.S.A. 109, 20379-84, 2012.
37. Pearl J, Leveson-Gower D, Lee A, Sun N, Negrin R, Wu JC*. Leukocyte Costimulatory Molecule Blockade Permits Allogeneic and Xenogeneic Engraftment of Pluripotent Stem Cells. Cell Stem Cell 8(3): 309-17, 2011.
38. Hammerick KE, Huang Z, Sun N, Lam MT, Prinz FB, Wu JC, Commons GW, Longaker MT*. Elastic Properties of Induced Pluripotent Stem Cells. Tissue Eng Part A. 17(3-4): 495-502, 2011.
39. Levi B, James AW, Nelson ER, Hu S, Sun N, Peng M, Wu J, Longaker MT*. Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plast Reconstr Surg. 127 (3): 1130-40, 2011.
40. Hu S, Huang M, Li Z, Jia F, Ghosh Z, Lijkwan MA, Fasanaro P, Sun N, Wang X, Martelli F, Robbins RC, Wu JC*. MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease. Circulation 122: S124-31, 2010.
41. Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC*. Dynamic MicroRNA Expression Programs during Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499. Circ Cardiovasc Genet. 3(5): 426-35, 2010.
42. Chen MQ, Xie X, Wilson KD, Sun N, Giovangrandi L, Wu JC, Kovacs GT*. Current-controlled electrical point-source stimulation of embryonic stem cells. Cellular and Molecular Bioengineering. 2009; 2(4) 625-635, 2009.
43. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC*. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells and Development. 18(5): 749-58, 2009.
44. 鹽酸克倫特羅對人類誘導多能幹細胞來源心肌細胞的毒性作用。楊慧；吳劭一；毛益申；王青潔；劉琛；周奕；孫寧。 《微循環學雜誌》, 04：15-86, 2015. [1] 
參考資料
  • 1.    孫寧  ．復旦大學基礎醫學院生理與病理生理學系[引用日期2020-05-14]