複製鏈接
請複製以下鏈接發送給好友

孫兵

(上海生命科學院生化細胞所抗體研究中心主任)

鎖定
孫兵,男,博士研究生,研究員。
現任中國科學院分子細胞科學卓越創新中心(生物化學與細胞生物學研究所) 研究組組長、博士生導師。 [1] 
中文名
孫兵
國    籍
中國
畢業院校
新疆醫科大學(學士、碩士)
上海第二醫科大學(博士)
性    別

孫兵人物經歷

孫兵教育背景

1978.10-1983.07 本科,新疆醫學院醫療系
1983.07-1986.09 碩士研究生,新疆醫學院藥理學專業
1988.03-1991.01 免疫學博士研究生,免疫學基礎,上海第二醫科大學

孫兵工作經歷

1986.09-1988.03 新疆醫學院藥學系助教
1991.01-1994.01 上海第一醫科大學藥學院講師、副教授
1994.01-1999.01 美國國立衞生研究院博士後和高級訪問學者
1998.05-2005.12 中科院上海生科院生化與細胞所研究員、研究組長[重點研究樹突狀細胞成熟與分化和T輔助細胞亞羣(Th1和Th2細胞)分化]
2005.12- 2016.12 中科院上海巴斯德所中方所長、研究員、研究組長(主要研究呼吸道流感病毒和SARS病毒感染的致病機制和抗HCV丙肝感染的免疫保護的機制研究) [2] 

孫兵社會任職

現為美國免疫學家學會會員(American Association of Immunologists; AAI),中國免疫學會副理事長。 [1] 

孫兵研究方向

Th細胞分化機制和ILC2細胞功能的研究及其在炎症和免疫性疾病中作用機制研究 [1] 

孫兵所獲榮譽

(1) 國家自然科學二等獎,2013
(2) 2012年度上海市自然科學二等獎,2012
(3) “優秀研究生導師”獎,2008
(4) 上海市優秀學科帶頭人,2007
(5) 千百萬人才工程獎,2004
(6) 上海市科技系統先進工作者,2004 [2] 
(7) 國家傑出青年研究基金獲得者,2003 [1] 

孫兵專利成果

( 1 ) SARS早期診斷的多肽及試劑盒, 發明, 2008, 第 1 作者, 專利號: 3128832.4
( 2 ) SARS冠狀病毒相關多肽及其應用, 發明, 2005, 第 1 作者, 專利號: ZL03129289.5
( 3 ) 一種SARS冠狀病毒藥物靶點及其應用, 發明, 2011, 第 1 作者, 專利號: ZL200610027476X
( 4 ) 檢測乙型肝炎病毒e抗原的試劑盒和用途, 發明, 2011, 第 1 作者, 專利號: ZL200610143423.4
( 5 ) SARS冠狀病毒的干擾RNA及其應用, 發明, 2007, 第 1 作者, 專利號: ZL2006 1 0027475.5
( 6 ) 抗-HBeAg單克隆抗體及其細胞株、製備方法和用途, 發明, 2008, 第 1 作者, 專利號: ZL2005 1 0030849.4
( 7 ) 抗-HBeAg單克隆抗體及其細胞株、製備方法和抗HBeAg單抗, 發明, 2008, 第 1 作者, 專利號: ZL200510030851.1
( 8 ) 針對禽流感病毒的重組聯合DNA疫苗, 發明, 2008, 第 1 作者, 專利號: 200810037040.8
( 9 ) 一種青藤鹼衍生物、合成方法及其用途, 發明, 2010, 第 1 作者, 專利號: 201010108675.X
( 10 ) 抗H5N1來源的血凝素蛋白的單克隆抗體及其應用, 發明, 2008, 第 1 作者, 專利號: 200810037362.2
( 11 ) 一種抗甲型H1N1流感病毒血凝素蛋白的抗體, 發明, 2010, 第 1 作者, 專利號: 201010174886.3
( 12 ) H5N1亞型禽流感假病毒的製備方法及其用途, 發明, 2010, 第 1 作者, 專利號: 201010118101.0
( 13 ) 甲型流感病毒疫苗哺乳動物細胞適應株的獲得方法和適應位點, 發明, 2013, 第 1 作者, 專利號: 201310098172.2
( 14 ) 一種中和丙型肝炎病毒的全人單克隆抗體及其用途, 發明, 2014, 第 1 作者, 專利號: 201410128238.2
( 15 ) 甲型流感病毒疫苗Vero細胞適應株的獲得方法和適應位點, 發明, 2014, 第 1 作者, 專利號: 201510091993.2
( 16 ) 針對胱抑素C的單克隆抗體、雜交瘤細胞株製備及其用途, 發明, 2013, 第 1 作者, 專利號: 201310153514.6
( 17 ) 細胞外基質蛋白1及其調節劑在製備過敏性疾病診斷或治療藥物中的應用, 發明, 2014, 第 1 作者, 專利號: ZL201010620105.9
( 18 ) protein and use thereof in treating multiple sclerosis, 發明, 2016, 第 1 作者, 專利號: US15/105930
( 19 ) protein and use thereof in treating multiple sclerosis, 發明, 2016, 第 1 作者, 專利號: 14872967.6 [2] 

孫兵代表論著

孫兵論文

  1. Chunyan Yi, Xiaoyu Sun , Jing Ye, Longfei Ding , Meiqin Liu , Zhuo Yang , Xiao Lu , Yaguang Zhang , Liyan Ma , Wangpeng Gu , Aidong Qu , Jianqing Xu , Zhengli Shi *, Zhiyang Ling* and Bing Sun*;Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cellular & Molecular Immunology ,2020,17:621–630.
  2. Yaguang Zhang, Xuezhen Li, Zhongguang Luo, Liyan Ma, Songling Zhu, Zhishuo Wang, Jing Wen, Shipeng Cheng, Wangpeng Gu, Qiaoshi Lian, Xinhao Zhao, Weiguo Fan, Zhiyang Ling, Jing Ye, Songguo Zheng, Dangsheng Li, Hongyan Wang, Jie Liu*, Bing Sun*; ECM1 is an essential factor for the determination of M1macrophage polarization in IBD in response to LPS stimulation, PNAS, 2020, 117(6): 3083-3092.
  3. Weiguo Fan, Tianhui Liu, Wen Chen, Seddik Hammad, Thomas Longerich,Ingrid Hausser, Yadong Fu, Nan Li, Yajing He, Cui Liu, Yaguang Zhang, Qiaoshi Lian, Xinhao Zhao, Chenghua Yan, Li Li, Chunyan Yi, Zhiyang Ling, Liyan Ma, Xinyan Zhao, Hufeng Xu, Ping Wang, Min Cong, Hong You, Zhihong Liu, Yan Wang, Jianfeng Chen, Dangsheng Li, Lijian Hui, Steven Dooley*, Jinlin Hou*, Jidong Jia* and Bing Sun* (2019). ECM1 Prevents Activation of Transforming Growth Factor beta, Hepatic Stellate Cells, and Fibrogenesis in Mice. Gastroenterology. 2019;157:1352–1367.
  4. Fang Yu*, Sharma Suveena, Dragana Jankovic, Rama Krishna Gurram, Pan Su, Gangqing Hu, Rao Li, Sadiye Rieder, Keji Zhao, Bing Sun*, Jinfang Zhu*; The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination, Journal of Experimental Medicine, 2018, 215(7): 1813-1821;
  5. Lan He , Wangpeng Gu , Meng Wang , Xiaoyan Chang , Xiaoyu Sun , Yuan Zhang , Xuan Lin , Chenghua Yan , Weiguo Fan , Pan Su , Yanming Wang , Chunyan Yi , Guomei Lin , Li Li , Yu Jiang , Junxia Lu , Chen Dong , Haikun Wang , Bing Sun*. Extracellular Matrix Protein 1 promotes follicular helper T cells differentiation and antibody production. PNAS, 2018,115(34):8621-8626.
  6. Qiaoshi Lian, Jun Xu, Shanshan Yan, Min Huang*, Honghua Ding, Xiaoyu Sun, Aiwei Bi, Jian Ding*, Bing Sun*, Meiyu Geng*, Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation. Cell Research ,2017,27:784-800.
  7. Wenshuai Wang, Xiaoyu Sun, Yanbing Li, Jinpeng Su, Zhiyang Ling, Tianlong Zhang, Fang Wang, Hong Zhang, Hualan Chen, Jianping Ding & Bing Sun*. Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature Communications, 2016;7: 13577
  8. Su Pan, Chen Sheng, Zheng Yuhan, Zhou Haiyan, Yan CH, Yu F, Zhang YG, He L, Zhang Y, Wang YM, Wu L, Wu XA, Yu BK, Ma LY, Yang ZR, Wang JH, Zhao GX, Zhu JF, Wu ZY, Sun B*. Novel Function of Extracellular Matrix Protein 1 in Suppressing Th17 Cell Development in Experimental Autoimmune Encephalomyelitis. Journal of Immunology 2016; 197(4): 1054-1064.
  9. Wang Yanming, Lian QS, Yang B, Yan SS, Zhou HY, He L, Lin GM, Lian ZX, Jiang ZF, Sun B*. TRIM30 alpha Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. Plos Pathogens.2015; 11(6):18.
  10. Sha Wenwen, Mitoma H, Hanabuchi S, Bao MS, Weng LY, Sugimoto N, Liu Y, Zhang ZQ, Zhong J, Sun B*, Liu YJ*. Human NLRP3 inflammasome senses multiple types of bacterial RNAs. PNAS. 2014; 111(45):16059-16064.
  11. OuYang Bo, Xie SQ, Berardi MJ, Zhao XH, Dev J, Yu WJ, Sun B*, Chou JJ*. Unusual architecture of the p7 channel from hepatitis C virus. Nature .2013; 498(7455):521.
  12. Mao Kairui, Chen SZ, Chen MK, Ma YL, Wang Y, Huang B, He ZY, Zeng Y, Hu Y, Sun SH, Li J, Wu XD, Wang XR, Strober W, Chen C, MengGX, Sun B*. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock. Cell Research .2013; 23(2):201-212.
  13. Zhenhu Li,Yuan Zhang, Zhiduo Liu, Xiaodong Wu, Yuhan Zheng, Zhiyun Tao, Kairui Mao, Jie Wang, Guomei Lin, Lin Tian, Yongyong Ji, Meiling Qin, Shuhui Sun, Xueliang Zhu, and Bing Sun*. Extra-Cellular Matrix protein 1 controls Th2 cell egress from lymph nodes through re-expression of sphingosine 1-phosphate receptor 1. Nature Immunology. 2011; 12(2):178-85
  14. Zhiduo Liu, Zhenhu Li, Kairui Mao, Jia Zou, Yuan Wang, Zhiyun Tao, Guomei Lin, Lin Tian, Yongyong Ji, Xiaodong Wu, Xueliang Zhu, Shuhui Sun, Weiguang Chen, Charlie Xiang and Bing Sun*. Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling. Journal of Immunology. 2009; 183(10):6320-9
  15. Xuexian O Yang, Pornpimon Angkasekwinai, Jinfang Zhu, Juan Peng, Zhiduo Liu, Roza Nurieva, Xikui Liu, Yeonseok Chung, Seon Hee Chang, Bing Sun*, Chen Dong*. Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment. Nature Immunology. 2009; 10(12):1260-6
  16. Mude Shi, Weiwen Deng, Enguang Bi, Kairui Mao, Yongyong Ji, Guomei Lin, Xiaodong Wu, Zhiyun Tao, Zhenhu Li, Xinfen Cai, Shuhui Sun, Charlie Xiang and Bing Sun*. TRIM30a negatively regulates TLR-mediated NF-kB activation by targeting TAB2 and TAB3 for degradation. Nature Immunology. 2008; 9(4):369-77.
  17. Wei Lu, Bojian Zheng, Ke Xu, Wolfgang Schwarz, Jiadong Cheng, Shuming Duan, Vincent Deubel, Bing Sun*. SARS-CoV 3a protein forms an ion channel and modulates virus release. PNAS. 2006; 103(33);12540-12545 [1] 

孫兵著作

(1) T輔助細胞的分化及其功能, T Helper Cell Differentiation and Their Function, springer, 2014-12, 第 1 作者 [2] 
參考資料