周恩民

2010年7月--：西北農林科技大學“后稷學者”特聘教授、動物醫學院院長

2007年7月至2010年6月:山東省“泰山學者海外特聘專家”；

山東農業大學動物科技學院、動物醫學院副院長；

2006年5月至2007年7月：“龍江學者” 特聘教授：黑龍江八一農墾大學動物科技學院

2000年6月至2006年4月：副教授、主任：美國衣阿華州立大學獸醫學院獸醫診斷和動物生產醫學系

2002年12月至2005年12月：客座教授：東北農業大學動物醫學院

1998年9月至2000年6月：副教授：加拿大明尼多巴大學農學院動物科學系，兼職

1992年4月至2000年5月：主任、高級研究員：加拿大國家食品檢驗檢疫總局國家外來病中心免疫診斷實驗室

1995年1月1998年12月：客座副教授：加拿大渥太華大學微生物免疫學系

1985年9月1988年8月：訪問學者，博士後：美國德可薩思州聖安東尼奧西南生物醫學研究所病毒免疫學系

1978年9月至1985年8月：助教：包頭醫學院微生物教研室 ^[1] 

1993年畢業於加拿大明尼多巴大學免疫學系，獲博士學位，

1985年1988年美國德可薩思州聖安東尼奧西南生物醫學研究所病毒免疫學系訪問學者，博士後。

1993年至2010年曾任加拿大國家食品檢驗檢疫總局國家外來病中心免疫診斷實驗室研究員、高級研究員和主任、美國衣阿華州立大學獸醫學院獸醫診斷和動物生產醫學系副教授獸醫診斷實驗室血清診斷實驗室主任、山東省“泰山學者海外特聘專家”等職。 ^[2] 

2011年入選陝西省“百人計劃”。 ^[2] 

陝西省動物疫情應急防治隊專家組副組長、國務院學位委員會第七屆學科評議組（獸醫學）成員、第九屆農業部科學技術委員會委員、教育部高等學校動物醫學專業教學指導委員會副主任委員、第四屆國家轉基因生物安全委員會委員、農業部基因克隆與轉基因技術執行專家組成員、農業部全國動物衞生風險評估專家委員會委員、中國免疫學會獸醫免疫分會第五屆委員會副主任委員、中國畜牧獸醫學會家畜傳染病學分會常務理事、中國畜牧獸醫學會獸醫公共衞生學分會常務理事。 ^[2] 

豬繁殖與呼吸綜合徵。豬繁殖與呼吸綜合徵病毒生物學、病毒與宿主互作、免疫調控、診斷試劑疫苗及生物製劑研發。

戊型肝炎。禽和豬戊型肝炎病毒生物學、病毒與宿主互作、致病機制、病毒跨種系傳播機制、診斷試劑疫苗及生物製劑研發。 ^[2] 

本科生《獸醫免疫學》及全英文《獸醫免疫學》；研究生《獸醫免疫學研究進展》、《獸醫學專題》。 ^[2] 

Jiming Gao, Shuqi Xiao, Yihong Xiao, Xiangpeng Wang, Chong Zhang, Qin Zhao, Baichen Huang, Hongliang Liu, Chengbao Wang, Ningning Liu, Junhua Lv, Taofeng Du, Yani Sun, Yang Mu, Gang Wang, Shahid Faraz Syed, Gaiping Zhang, Julian A. Hiscox, Ian Goodfellow and En-Min Zhou*. MYH9is an EssentialFactor for Porcine Reproductive and RespiratorySyndrome VirusInfection.Sci Reports.2016 Apr 26;6:25120. doi: 10.1038/srep25120.

Yongkun Dua,Taofeng Du,Yunpeng Shi, Angke Zhang, Chong Zhang, Yuwen Diao,Guangyi Jin*, En-Min Zhou*.Synthetic Toll-like receptor 7 ligand inhibits porcine reproductive and respiratory syndrome virus infection in primary porcine alveolar macrophages. Antiviral Res. doi:10.1016/j.antiviral.2016.04.005.

Liu H, Liang C, Duan H, Zhang X, Wang X, Xiao S,Zhou EM*. Intracellularly expressed nanobodies against non-structural protein 4 of porcine reproductive and respiratory syndrome virus inhibit virus replication. Biological Lett. DOI 10.1007/s10529-016-2086-3

Yiyang Chen, Qin Zhao, Baoyuan Liu, Lizhen Wang, Yani Sun, Huixia Li, Xinjie Wang, Shahid Faraz Syed, Gaiping Zhang, En-Min Zhou*. A novel blocking ELISA for detection of antibodies against hepatitis E virus in domestic pigs.Plos One. 2016 Mar 29;11(3):e0152639.

Qiongyi Li, Xiangpeng Wang, Chengbao Wang, Ying Yu, Gang Wang,Jiming Gao, Hongliang Liu, Huali Xie, Baicheng Huang, Zhijun Li, Ning Kong, Taofeng Du, Yang Mu, Shuqi Xiao, Qin Zhao, Yani Sun, Xingang Xu,Gaiping Zhang, Walter H. Hsuand En-Min Zhou*.Intracellular expression of an anti-idiotypic antibody single-chain variable fragment inhibits porcine reproductive and respiratory syndrome virusinfectionin Marc-145 cells. Antiviral Therapy. 2016;21(2):161-70.doi:10.3851/IMP2980, 20150727. IF：3.02被引次數：0

Hongliang Liu, Yan Wang, Hong Duan, Angke Zhang, Chao Liang, Jiming Gao, Chong Zhang, Baicheng Huang, Qiongyi Li,Na Li, Shuqi Xiao, En-Min Zhou*. An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication. Vet Microbiol. 2015, 181:252-260.

Chong Zhang, Fengxing Pu, Angke Zhang, Lele Xu, Na Li, Yunhuan Yan, Jiming Gao, Hongliang Liu, Gaiping Zhang, Ian G. Goodfellow, En-Min Zhou*, Shuqi Xiao*. Heme Oxygenase-1 Suppresses Bovine Viral Diarrhoea Virus Replication in vitro.Sci Reports. 2015 Oct 29;5:15575. doi: 10.1038/srep15575.

Zhijun Li, Gang Wang, Yan Wang, Chong Zhang, Xinglong Wang, Baicheng Huang, Qiongyi Li, Liangliang Li, Biyun Xue, Peiyang Ding, Shahid Faraz Syed, Chengbao Wang*, Xuehui Cai*, En-Min Zhou*.Rescue and evaluation of a recombinant PRRSV expressing porcine Interleukin-4. Virol J.2015, 12:185-194.

Qin Zhao, Shahid Faraz Syed, En-Min Zhou*. Antigenic Properties of Avian Hepatitis E Virus Capsid Protein. Vet Microbiol. 2015, 180:10-14.

Zhijun Li, Gang Wang, Yan Wang, Chong Zhang, Baicheng Huang, Qiongyi Li, Liangliang Li, Biyun Xue, Peiyang Ding, Xuehui Cai, Chengbao Wang*, En-Min Zhou*.Immune responses of pigs immunized with a recombinant porcine reproductive and respiratory syndrome virus expressing porcine GM-CSF. Vet Immunol Immunopathol.2015, 168:40-48.

Qin Zhao, Sha Xie, Yani Sun, Yiyang Chen, Jiming Gao, Huiya Li, Xinjie Wang, Shahid Faraz Syed, Baoyuan Liu, Lizhen Wang, Gaiping Zhang and En-Min Zhou*. Development and evaluation of a SYBR Green real-time RT-PCR assay for detection of avian Hepatitis E virus. BMC Vet Res.2015, 11:195-201.

Yang Mu, Liangliang Li, Beibei Zhang, Baicheng Huang, Jiming Gao, Xiangpeng Wang, Chengbao Wang, Shuqi Xiao, Qin Zhao, Yani Sun, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*. Glycoprotein 5 of porcine reproductive and respiratory syndrome virus strain SD16 inhibits viral replication and causes G2/M cell cycle arrest, but does not induce cellular apoptosis in Marc-145 cells. Virol. 2015, 484:136-145.

Gang Wang, Ying Yu, Yabin Tu, Jie Tong, Yonggang Liu, Chong Zhang, Yafei Chang, Shujie Wang, Chenggang Jiang, En-Min Zhou*, Xuehui Cai*.Highly pathogenicporcine reproductive and respiratory syndrome virus infectioninduced apoptosis and autophagy in thymi of infected piglets.PLoS ONE10(6): e0128292. doi:10.1371/journal.pone.0128292.

Xinjie Wang, Qin Zhao, Lu Dang, Yani Sun, Jiming Gao, Baoyuan Liu, Shahid Faraz Syed, Hu Tao, Gaiping Zhang, Jianxun Luo, and En-Min Zhou*. Characterization of two novel linear B-cell epitopes in the capsid protein of avian hepatitis E virus (HEV) that are common to avian, swine, and human HEVs.J Virol. 2015, 89(10):5491-5501.

Shuqi Xiao, Xue Wang, Huaibao Ni,Na Li,Angke Zhang, Hongliang Liu,Fengxing Pu, Lele Xu, Jiming Gao, Qin Zhao, Yang Mu, Chengbao Wang,Yani Sun, Taofeng Du, Xingang Xu, Gaiping Zhang, Julian A. Hiscox, Ian G. Goodfellow, En-Min Zhou*.MiR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression. J Virol. 2015, 89(8):4494-4503

Ying Yu, Gang Wang, Qiongyi Li, Yongkun Du, Taofeng Du, Yang Mu, Shuqi Xiao, Qin Zhao, Chengbao Wang,Yani Sun, Xingang Xu, Gaiping Zhang, Walter H. Hsu, Xuehui Cai*and En-Min Zhou*. Single-chain anti-idiotypic antibodyretains it specificitytoporcine reproductive and respiratory syndrome virus GP5. Immunol Letters. 2014,163(1):8-13.

Qin Zhao, Yani Sun, Gaiping Zhang,Frederik Widén, En-Min Zhou*. Antigenicdomains of avian HEV: bases for serological diagnosisof HEV in avian, swine and human. British J Virol. 2014,1(3): 103-105.

Lizhen Wang, Yani Sun, Taofeng Du, Chengbao Wang, Shuqi Xiao, Yang Mu, Gaiping Zhang, Lihong Liu, Frederik Widén, Walter H. Hsu, Qin Zhao* and En-Min Zhou*. Identification of an antigenic domain in the N-terminal region of avian hepatitis E virus (HEV) capsid protein that is not common to swine and human HEVs. J Gen Virol. 2014,95:2710-2715.

Jiming Gao, Pengchao Ji, Maodong Zhang, Xiangpeng Wang, Chengbao Wang, Shuqi Xiao, Yang Mu, Qin Zhao, Taofeng Du, Yani Sun, Julian A. Hiscox, Gaiping Zhang, En-Min Zhou*. GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity. Vet Microbiol. 2014,174(3–4):409-418.

Xiao YH, Wang TT, Zhao Q, Wang CB, Lv JH, Nie L, Gao JM, Ma XC, Hsu WH, Zhou EM*. Development of indirect ELISAs for differential serodiagnosis of classical and highly pathogenic porcine reproductive and respiratory syndrome virus. Transbound Emerg Dis. 2014,61:341–349.

Baoyuan Liu, Qin Zhao, YaniSun, Xinjie Wang, Jinan Zhao, Taofeng Du, Chengbao Wang, Shuqi Xiao, Yang Mu, Gaiping Zhang Jianxun Luo, Walter H. Hsu,En-Min Zhou*.Development of a blocking ELISA for detection of antibodies against avian Hepatitis E virus. J Virological Methods. 2014, 204:1-5.

Shuqi Xiao, Angke Zhang, Chong Zhang, Huaibo Ni, Jiming Gao, Chengbao Wang, Qin Zhao, Xiangpeng Wang, Xue Wang, Chao Ma, Hongliang Liu, Na Li, Yang Mu, Yani Sun, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*.Heme oxygenase-1acts as an anti-viral factor forporcine reproductive and respiratory syndrome virus replication and over-expression inhibits virus biology. Antiviral Res. 2014, 110:60–69.

Xin-jie Wang, Qin Zhao, Feng-lin Jiang, Bao-yuan Liu, Ji-nan Zhao, Lu Dang, Ya-ni Sun, Yang Mu, Shu-qi Xiao, Cheng-bao Wang, Walter H. Hsu, Lihong Liu, Frederik Widén, En-Min Zhou*. Genetic characterization and serological prevalence of swine hepatitis E virus in Shandong province, China. Vet Microbiol. 2014, 172:415–424.

Ying Yu, XuehuiCai, Gang Wang, NingKong, YonggangLiu, YihongXiao, Chong Zhang, Yang Mu, Shuqi Xiao, Qin Zhao, Chengbao Wang, Gaiping Zhang, Julian A. Hiscox, En-Min Zhou*. Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSVchallenge. BMC Vet Res. 2014, 10:39-48.

Qin Zhao, Ya-ni Sun, Shou-bin Hu, Xin-jie Wang, Yi-hong Xiao, Walter H.Hsu, Shu-qi Xiao, Cheng-bao Wang, Yang Mu, Julian A. Hiscox, En-Min Zhou*.Characterization of antigenic domains and epitopes in the ORF3 protein of a Chinese isolate of avian hepatitis E virus. Vet Microbiol. 2013,167:242–249.

Chengbao Wang, Baicheng Huang, Qiongyi Li, Yuping Ma, Ning Kong, Zhijun Li, Jiming Gao, Chong Zhang, Chao Liang, Lu Dang, Fernando Almazan, Luis Enjuanes and En-Min Zhou*. A novel porcine reproductive and respiratory syndrome virus vector system that stably expresses enhanced green fluorescent protein as a separate transcription unit. Vet Res. 2013, 44:104-114.

Xiangpeng Wang, Ruifang Wei, Qiongyi Li, Hongliang Liu, Baicheng Huang, Jiming Gao, Yang Mu, Chengbao Wang, Walter H. Hsu, Julian A. Hiscox, En-Min Zhou*. PK-15 cells transfected with porcine CD163 by PiggyBac transposon systemaresusceptible to porcine reproductive and respiratory syndrome virus. J Virological Methods. 2013, 193:383-390.

Qin Zhao, Yani Sun, Jinan Zhao, Shoubin Hu, Feifei Zhao, Fuyong Chen, Alfonso Clavijo, En-Min Zhou*, Yihong Xiao*.The development and application of an indirect ELISA to detect antibodies against avian hepatitis E virus. J Virological Methods. 2013,187:32-36.

Chengbao Wang, Qin Zhao, Chao Liang, Lu Dang, Yuping Ma, Jiming Gao, Qiongyi Li, Baicheng Huang, Ning Kong, Chong Zhang,and En-Min Zhou*. Complete Genome Sequence of a Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Variant. J Virol. 2012, 86:8906.

Gang Wang, Tengfei Song, Ying Yu, Yonggang Liu, Wenda Shi, Shujie Wang, Fulong Rong, Jianguo Dong, He Liu, Xuehui Cai, En-Min Zhou*. Immune responses in piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Vet Immunol Immunopathol. 2011,142:170-178.

Shiwei Dong, Qin Zhao, Mingzhe Lu, Peiming Sun, Hongkai Qiu, Lu Zhang Junhua Lv, En-Min Zhou*.Analysis of epitopes in the capsid protein of avian hepatitis E virus by using monoclonal antibodies. J Virol Methods. 2011, 171:374-380.

Qin Zhao, En-Min Zhou*, Shi-Wei Dong, Hong-Kai Qiu, Lu Zhang, Shou-Bin Hu, Fei-Fei Zhao, Shi-Jin Jiang, and Ya-Ni Sun. Analysis of Avian Hepatitis E Virus from Chickens, China. EID. 2010,16:1469-1472. ^[2]