吳蓓麗

吳蓓麗(7張)

1979年1月，吳蓓麗出生於河南南召，原籍江蘇吳江。

1994年9月—1997年7月，高中就讀於江蘇省無錫市第一中學 ^[12]  。

1997年9月—2001年7月，就讀於北京師範大學生物系生物化學專業，畢業並獲得學士學位 ^[11]  。

2001年9月—2006年6月，就讀於清華大學生物科學與技術系生物物理學專業，師從結構生物學專家饒子和院士 ^[10]  ，畢業並獲得博士學位。

2007年4月—2011年7月，在美國斯克利普斯研究所（Scripps Research）分子生物學系從事博士後研究工作。

2011年7月，入選中國科學院百人計劃，回國後擔任中國科學院上海藥物研究所藥物靶標結構與功能中心研究員、課題組長 ^[4]  。

2012年9月，加入中國民主同盟；同年，入選上海市“浦江人才計劃”，並被聘為國家重點基礎研究發展計劃（973計劃）課題負責人 ^[32]  。

2014年，獲得國家自然科學基金“優秀青年科學家基金項目”資助。

2018年8月，獲得國家傑出青年科學基金資助；同年，入選中組部“萬人計劃”青年拔尖人才、科技創新領軍人才 ^{[3]  [25]}  。

吳蓓麗主要針對重要藥物靶標蛋白家族G蛋白偶聯受體（GPCR）開展結構與功能研究，並進行基於結構的藥物研發。通過測定GPCR與不同類型配體及下游效應蛋白的複合物三維結構，闡明不同GPCR對配體的選擇性識別模式及信號的特異性轉導機制，為靶向GPCR的藥物研發提供線索和依據 ^[3]  。

根據2024年1月中國科學院上海藥物研究所網站數據，吳蓓麗先後在學術期刊Nature、Science和Cell發表13篇研究論文 ^[3]  。

Qiuxiang Tan#, Ya Zhu#, Jian Li, Zhuxi Chen, Gye Won Han, Irina Kufareva, Tingting Li, Limin Ma, Gustavo Fenalti, Jing Li, Wenru Zhang, Xin Xie, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Hong Liu, Raymond C. Stevens, Qiang Zhao, Beili Wu*. Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex [J]. Science 341:1387-1390, 2013.

Kaihua Zhang#, Jin Zhang#, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M. Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu & Qiang Zhao*. Structure of the human P2Y12 receptor in complex with an antithrombotic drug [J]. Nature 509:115-118, 2014.

Jin Zhang#, Kaihua Zhang#, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E. Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A. Jacobson, Raymond C. Stevens, Beili Wu* & Qiang Zhao*. Agonist-bound structure of the human P2Y12 receptor [J]. Nature 509:119-122, 2014.

Dandan Zhang, Zhan-Guo Gao, Kaihua Zhang, Evgeny Kiselev, Steven Crane, Jiang Wang, Silvia Paoletta, Cuiying Yi, Limin Ma, Wenru Zhang, Gye Won Han, Hong Liu, Vadim Cherezov, Vsevolod Katritch, Hualiang Jiang, Raymond C. Stevens, Kenneth A. Jacobson, Qiang Zhao* & Beili Wu*. Two disparate ligand binding sites in the human P2Y1 receptor [J]. Nature 520:317-321, 2015.

Haonan Zhang#, Anna Qiao#, Dehua Yang#, Linlin Yang#, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang*, Ming-Wei Wang* & Beili Wu*. Structure of the full-length glucagon class B G protein-coupled receptor [J]. Nature 546:259-264, 2017.

Haonan Zhang, Anna Qiao, Linlin Yang, Ned Van Eps, Klaus S. Frederiksen, Dehua Yang, Antao Dai, Xiaoqing Cai, Hui Zhang, Cuiying Yi, Can Cao, Lingli He, Huaiyu Yang, Jesper Lau, Oliver P. Ernst, Michael A. Hanson, Raymond C. Stevens, Ming-Wei Wang, Steffen Reedtz-Runge, Hualiang Jiang, Qiang Zhao* & Beili Wu*. Structure of the glucagon receptor in complex with a glucagon analogue [J]. Nature 553:106-110, 2018.

Zhenlin Yang#, Shuo Han#, Max Keller#*, Anette Kaiser#, Brian J. Bender#, Mathias Bosse, Kerstin Burkert, Lisa M. Kogler, David Wifling, Guenther Bernhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, Beibei Li, Sheng Ye, Rongguang Zhang, Bo Xu, Dan Larhammar, Raymond C. Stevens, Daniel Huster, Jens Meiler, Qiang Zhao, Annette G. Beck-Sickinger*, Armin Buschauer & Beili Wu*. Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor [J]. Nature 556:520-524, 2018.

Can Cao#, Qiuxiang Tan#, Chanjuan Xu, Lingli He, Linlin Yang, Ye Zhou, Yiwei Zhou, Anna Qiao, Minmin Lu, Cuiying Yi, Gye Won Han, Xianping Wang, Xuemei Li, Huaiyu Yang, Zihe Rao, Hualiang Jiang, Yongfang Zhao, Jianfeng Liu, Raymond C. Stevens, Qiang Zhao, Xuejun C. Zhang* and Beili Wu*. Structural basis for signal recognition and transduction by platelet-activating-factor receptor [J]. Nature Structural & Molecular Biology 25:488-495, 2018.

Hengxin Fan#, Shuanghong Chen#, Xiaojing Yuan, Shuo Han, Hui Zhang, Weiliang Xia, Yechun Xu, Qiang Zhao* and Beili Wu*. Structural basis for ligand recognition of the human thromboxane A2 receptor. Nature Chemical Biology 15:27-33, 2019.

Shuanghong Chen#, Mengjie Lu#, Dongsheng Liu#, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu*, Kurt Wuthrich* & Qiang Zhao*. Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography [J]. Nature Communications 10:638, 2019.

Tong Chen#, Muya Xiong#, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu*, Qiang Zhao* & Beili Wu*. Structural basis of ligand binding modes at the human formyl peptide receptor 2 [J]. Nature Communications 11(1):1208, 2020.

Anna Qiao#, Shuo Han#, Xinmei Li#, Zhixin Li#, Peishen Zhao#, Antao Dai, Rulve Chang, Linhua Tai, Qiuxiang Tan, Xiaojing Chu, Limin Ma, Thor Seneca Thorsen, Steffen Reedtz-Runge, Dehua Yang, Ming-Wei Wang, Patrick M. Sexton, Denise Wootten*, Fei Sun*, Qiang Zhao*, Beili Wu*. Structural basis of Gs and Gi recognition by the human glucagon receptor [J]. Science 367:1346-1352, 2020.

Tingting Tang#, Christin Hartig#, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao*, Annette G. Beck-Sickinger* & Beili Wu*. Structural basis for ligand recognition of the neuropeptide Y Y2 receptor [J]. Nature Communications 12:737, 2021.

Shuling Lin#, Shuo Han#, Xiaoqing Cai#, Qiuxiang Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, Cuiying Yi, Xiaojing Chu, Antao Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang*, Qiang Zhao* & Beili Wu*. Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4 [J]. Nature 594:583-588, 2021.

Juan Du#, Dejian Wang#, Hongcheng Fan#, Chanjuan Xu#, Linhua Tai#, Shuling Lin#, Shuo Han, Qiuxiang Tan, Xinwei Wang, Tuo Xu, Hui Zhang, Xiaojing Chu, Cuiying Yi, Peng Liu, Xiaomei Wang, Yu Zhou, Jean-Philippe Pin, Philippe Rondard, Hong Liu*, Jianfeng Liu*, Fei Sun*, Beili Wu* & Qiang Zhao*. Structures of human mGlu2 and mGlu7 homo- and heterodimers [J]. Nature 594:589-593, 2021.

Hui Zhang#, Kun Chen#, Qiuxiang Tan#, Qiang Shao#, Shuo Han#, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu*, Yechun Xu*, Qiang Zhao*, Beili Wu*. Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 [J]. Nature Communications 12:4151, 2021.

Xuefeng Zhang#, Chenglin He#, Mu Wang#, Qingtong Zhou#, Dehua Yang#, Ya Zhu#, Wenbo Feng, Hui Zhang, Antao Dai, Xiaojing Chu, Jia Wang, Zhenlin Yang, Yi Jiang, Ulrich Sensfuss, Qiuxiang Tan, Shuo Han, Steffen Reedtz-Runge, Eric H. Xu, Suwen Zhao*, Ming-Wei Wang*, Beili Wu*, Qiang Zhao*. Structures of the human cholecystokinin receptors in complex with agonists and antagonists [J]. Nature Chemical Biology 17:1230-1237, 2021.

Ya Zhu#, Xiaowen Lin#, Xin Zong#, Shuo Han#, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao*, Beili Wu*. Structural basis of FPR2 in recognition of Ab42 and neuroprotection by humanin [J]. Nature Communications 13:1775, 2022.

Xiangli Qu#, Na Qiu#, Mu Wang#, Bingjie Zhang#, Juan Du, Zhiwei Zhong, Wei Xu, Xiaojing Chu, Limin Ma, Cuiying Yi, Shuo Han, Wenqing Shui*, Qiang Zhao* & Beili Wu*. Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1 [J]. Nature 604:779-785, 2022.

吳蓓麗為抗艾滋病毒新藥研發作出了突出貢獻 ^[10]  。（樹森蘭娟院士人才基金評）

吳蓓麗委員積極履職盡責踐行政協委員職能，為生物醫藥領域傳遞了積極的聲音、貢獻了眾多的智慧 ^[21]  。（時任上海市政協副主席壽子琪評）