吳畏

1987——1991，四川大學 學士；

1991——1994，四川大學 碩士；

1996——2001，德國海德堡大學 博士；

2001——2005，德國癌症研究中心 博士後；

2005-—— ~ ，清華大學教授。 ^[1] 

■ 以非洲爪蟾（Xenopus laevis）為模式生物, 研究脊椎動物早期胚胎髮育, 特別是胚胎頭尾軸形體建成的分子機制。

■ 利用細胞培養和爪蟾胚胎，研究Wnt信號轉導及調控的分子機制。 ^[1] 

1. Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z,Wu W. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis.Oncogene. 2015 Mar 9.

2. Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG,Wu W. Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression.J Cell Sci. 2014 Nov 15;127(22):4833-45.

3. Zhu G, Fan Z, Ding M, Mu L, Liang J, Ding Y, Fu Y, Huang B,Wu W. DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation.J Biol Chem. 2014 May 30;289(22):15482-15494.

4. Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B,Wu W#, and Li H#. Molecular basis underlyinghistone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1.Genes Dev. 2014 Mar 15;28(6):622-36. (#: co-corresponding author) (Featured by F1000)

5. Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J,Wu W. SRSF1 and SRSF9 RNA binding proteins promote Wnt signaling-mediated tumorigenesis by enhancing β-catenin biosynthesis.EMBO Mol Med. 2013 May;5(5):737-50.

6. Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A,Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells.Oncogene. 2012 Feb 23;31(8):1001-12.

7. Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C,Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation.Mol Cell Biol. 2011 Jul;31(13):2577-90.

8. Chai G, Ma C, Bao K, Zheng L, Wang X, Sun Z, Salo E, Adell T,Wu W. Complete functional segregation of planarian beta-catenin-1 and -2 in mediating Wnt signaling and cell adhesion.J Biol Chem. 2010 Jul 30;285(31):24120-30.

9. Wang Y, Fu Y, Gao L, Zhu G, Liang J, Gao C, Huang B, Fenger U, Niehrs C, Chen YG,Wu W.Xenopusskip modulates Wnt/beta-catenin signaling and functions in neural crest induction.J Biol Chem. 2010 Apr 2;285(14):10890-901.

10. *Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)

11. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C,Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required forXenopusmyogenesis.Dev Cell. 2004 Oct; 7(4): 525-34.

12. *Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.Nature. 2001 May 17; 411(6835):321-5. ^[1]