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吳愛國

（中國科學院寧波材料技術與工程研究所研究員）

鎖定
吳愛國，博士，研究員。 [1]  2003年博士畢業於中科院長春應用化學研究所電分析化學國家重點實驗室，師從汪爾康院士、李壯研究員，曾獲中科院彭蔭剛冠名獎學金。2009年開始任中國科學院寧波材料技術與工程研究所研究員，現任中國科學院寧波材料技術與工程研究所-慈溪生物醫學工程研究所所長。 [2] 
2024年5月27日，當選2024國際生物材料科學與工程學會聯合會“生物材料科學與工程Fellow”。 [5] 
中文名
吳愛國
外文名
Aiguo Wu
國    籍
中國
民    族
漢族
畢業院校
中科院長春應用化學研究所電分析化學國家重點實驗室
職    務
研究員
主要成就
曾獲中科院彭蔭剛冠名獎學金
學    位
博士

目錄

  1. 1 基本信息
  2. 2 主要論文
  1. 3 代表專利
  2. 4 研究項目
  1. 5 榮譽獎勵
  2. 6 會員身份

吳愛國基本信息

多年來，先後主持NSFC面上項目、浙江省傑出青年基金等項目20餘項，與企業的合作項目業已進入產業化中試階段。參與了研究生的指導和課程教學工作，已在Chem Soc. Rev., Biomaterials, Adv. Mater., Nano Lett., ACS Nano, PNAS, Chem. Commun., J. Mater. Chem. B, Nanoscale, Adv. Sci., Adv Health. Mater. 等學術雜誌發表論文190餘篇（封面等19篇）；申請中美專利132項，已獲授權60項（包括美國專利1項和瑞士專利1項）；撰寫專著1部《Nanomaterials for Tumor Targeting Theranostic》；受邀請參會90餘次，其中作邀請報告50餘次；其工作已被國際期刊/學位論文正面引用超過7600次，H-指數=47。是Nature commun.,Adv.Mater., Adv.Funct.Mater., ACS Nano, EST, Nanomedicine等100餘種國際雜誌的特約審稿評論人，1個國際學術雜誌的副主編，3個國際學術雜誌的編委會成員，是中國化學會、中國生物材料委員會、中國生物物理學會、美國化學會和美國顯微學會會員。在材料所的研究興趣集中於: (1)納米材料的診療基礎研究與應用; (2)納米材料在環境科學中的基礎研究及應用; (3)基於生物分子構建的具有納米尺度的基礎研究及應用。

吳愛國主要論文

  1. Zheyu Shen, Ting Liu, Zhen Yang, Zijian Zhou, Wei Tang, Wenpei Fan*, Yijing Liu, Jing Mu, Ling Li, Vladimir I. Bregadze, Swadhin K. Mandal, Anna A. Druzina, Zhenni Wei, Xiaozhong Qiu*,Aiguo Wu*, Xiaoyuan Chen*.Small-sized gadolinium oxide based nanoparticles for high-efficiency theranostics of orthotopic glioblastoma.Biomaterials2020,235, 119783.
  2. Zhenni Wei, Zhenqi Jiang, Chunshu Pan, Jianbi Xia, Kaiwei Xu, Ting Xue, Bo Yuan, Ozioma Udochukwu Akakuru, Chengjie Zhu, Guilong Zhang, Zheng Mao, Xiaozhong Qiu*,Aiguo Wu*, Zheyu Shen*.Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis.Small2020, 1906870, DOI: 10.1002/smll.201906870 .
  3. Zheyu Shen, Wenpei Fan*, Zhen Yang, Yijing Liu, Vladimir I. Bregadze, Swadhin K. Mandal, Bryant C. Yung, Lisen Lin, Ting Liu*, Wei Tang, Lingling Shan, Yuan Liu, Shoujun Zhu, Sheng Wang, Weijing Yang, L. Henry Bryant, Duong T. Nguyen,Aiguo Wu*, Xiaoyuan Chen*. Exceedingly Small Gadolinium Oxide Nanoparticles with Remarkable Relaxivities for Magnetic Resonance Imaging of Tumors.Small2019, 1903422, DOI: 10.1002/smll.201903422.
  4. Chuang Liu, Jie Xing, Ozioma Udochukwu Akakuru, Lijia Luo, Shan Sun, Ruifen Zou, Zhangsen Yu, Qianlan Fang, andAiguo Wu*. Nanozymes-Engineered Metal−Organic Frameworks for Catalytic Cascades-Enhanced Synergistic Cancer Therapy.Nano Letters, 2019, 19, 5674−5682.
  5. Zhenqi Jiang, Yinjie Wang, Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li,Aiguo Wu, Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo,Biomaterials, 2019, 197, 41-50.
  6. Zheyu Shen, Ting Liu, Yan Li, Joseph Lau, Zhen Yang, Wenpei Fan, Zijian Zhou, Changrong Shi, Chaomin Ke, Vladimir I. Bregadze, Swadhin K. Mandal, Yijing Liu*,Zihou Li, Ting Xue, Guizhi Zhu, Jeeva Munasinghe, Gang Niu,Aiguo Wu*, and Xiaoyuan Chen*, Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors,ACS Nano., 2018, 12, 11355−11365.
  7. Zheyu Shen, Jibin Song, Zijian Zhou, Bryant C. Yung, Maria A. Aronova, Yan Li, Yunlu Dai, Wenpei Fan, Yijing Liu*, Zihou Li, Huimin Ruan, Richard D. Leapman, Lisen Lin, Gang Niu, Xiaoyuan Chen*,Aiguo Wu*, Dotted Core-Shell Nanoparticles with Superhigh r1 and Very Low r2/r1 for T1-Weighted MRI of Tumors,Adv Mater., 2018, 30, 1803163.
  8. Chuang Liu, Lijia Luo, Leyong Zeng, Jie Xing, Yuanzhi Xia, Shan Sun, Luyun Zhang, ZheYu, Junlie Yao, Zhangsen Yu, Ozioma Udochukwu, Akakuru, Madiha Saeed,Aiguo Wu. *, Porous gold nanoshells on functional NH2-MOFs: facile synthesis and designable platforms for cancer multiple therapy.Small, 2018, 14, 1801851. (Featutred in Front Cover, Top 10(7) in Small in 2018/08)
  9. Zhenqi Jiang, Yuchen Tian, Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Juan Li, Jian Yang, andAiguo Wu, pH protective Y1receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time,Biomaterials, 2018, 170, 70-81.
  10. Zheyu Shen, Jibin Song, Bryant C. Yung, Zijian Zhou*,Aiguo Wu*, and Xiaoyuan Chen*, Emerging Strategies of Cancer Therapy Based on Ferroptosis,Adv. Mater., 2018, 30, 201704007. (Featured in Frontspecies, Invited Review)
  11. Qiuyu Gong, Ruifen Zou, Jie Xing, Lingchao Xiang, Renshuai Zhang, andAiguo Wu*. An Ultrasensitive Near-Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine,Adv. Sci., 2018, 5, 1700664.
  12. Yuanzhi Xia#, Xuehua Ma #, Junhua Gao, Guoxin Chen, Zihou Li, Xiaoxia Wu, Zhangsen Yu, Jie Xing, Li Sun, Huimin Ruan, Lijia Luo，Lingchao Xiang, Chen Dong, Wenzhi Ren, Zheyu Shen *,Aiguo Wu*. A Flexible Caterpillar-Like Gold Nanoparticle Assemblies with Ultra-Small Nanogaps for Enhanced Dual-Modal Imaging and Photothermal Therapy,Small, 2018, 14, 1800094.
  13. Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song,* Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen,*Aiguo Wu*. Multifunctional Theranostic Nanoparticles Based on Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1‑Weighted Magnetic Resonance Imaging and Chemotherapy,ACS Nano, 2017, 11, 10992−11004.
  14. Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lin gchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang,Aiguo Wu *, Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging,Biomaterials, 2017, 116, 106-117.
  15. Zheyu Shen,Aiguo Wu*, and Xiaoyuan Chen*. Current detection technologies for circulating tumor cells.Chem. Soc. Rev., 2017,46, 2038-2056. (Invited Review, Front Inside Cover)
  16. Leyong Zeng, Yuanwei Pan, Ruifen Zou, Jinchao Zhang, Ying Tian, Zhaogang Teng, Shouju Wang, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*andAiguo Wu*. 808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer.Biomaterials, 2016,103, 116-127.
  17. Zheyu Shen, Hao Wu, Sugeun Yang, Xuehua Ma, Zihou Li, Mingqian Tan* andAiguo Wu*. A novel Trojan-horse targeting strategy to reduce the non-specific uptake of nanocarriers by noncancerous cells.Biomaterials, 2015,70, 1-11.
  18. Lulu Pan; Shan Sun; Aidi Zhang; Kai Jiang; Ling Zhang; Chaoqing Dong; Qing Huang;Aiguo Wuand Hengwei Lin*, Truly fluorescent excitation-dependent carbon dots and their applications in multicolor cellular imaging and multidimensional sensing,Advanced Materials, 2015,27, 7782-7787.
  19. Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu* andAiguo Wu*. Doxorubicin-loaded NaYF4: Yb/Tm-TiO2inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers.Biomaterials, 2015,57, 93-106.
  20. Ling'e Zhang, Leyong Zeng*, Yuanwei Pan, Song Luo, Wenzhi Ren, An Gong, Xuehua Ma, Hongze Liang, Guangming Lu* andAiguo Wu*. Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers.Biomaterials, 2015,44, 82-90.
  21. Kai Jiang, Shan Sun, Ling Zhang, Yue Lu,Aiguo Wu, Congzhong Cai and Hengwei Lin*. Red, green, and blue luminescence by carbon dots: Full-color emission tuning and multicolor cellular imaging.Angewandte Chemie Int. Edition., 2015,127, 5450-5453.(Featured in VIP paper)
  22. Zhenzhi Shi, Wenzhi Ren, An Gong, Xinmei Zhao, Yuehong Zou, Eric Michael Bratsolias Brown, Xiaoyuan Chen,Aiguo Wu*. Stability enhanced polyelectrolyte-coated gold nanorodphotosensitizer complexes for high/low power density photodynamic therapy.Biomaterials, 2014,35, 7058-7067.
  23. Christine A. Falaschetti, Tatjana Paunesku, Jasmina Kurepa, Dhaval Nanavati, Stanley S. Chou, Mrinmoy De, MinHa Song, Jung-tak Jang,Aiguo Wu, Vinayak P. Dravid, Jinwoo Cheon, Jan Smalle and Gayle E. Woloschak. Negatively Charged Metal Oxide Nanoparticles Interact with the 20S Proteasome and Differentially Modulate Its Biologic Functional Effects.ACS nano, 2013,7, 7759-7772.
  24. Kenneth T. Thurn, Tatjana Paunesku,Aiguo Wu,Eric M. B. Brown, Barry Lai, Stefan Vogt, Jörg Maser, Mohammed Aslam, Vinayak Dravid, Raymond Bergan and Gayle E. Woloschak. Labeling TiO2Nanoparticles with Dyes for Optical Fluorescence Microscopy and Determination of TiO2-DNA Nanoconjugate Stability.Small, 2009,5, 1318-1325. [3] 

吳愛國代表專利

1、Fe3O4複合TiO2納米粒子及其製備方法以及在磁共振成象造影劑中的應用
2、水溶性具有核殼結構或核冕殼結構的材料的製備方法
3、Multifunction Nanoconjugates for Imaging Applications and Targeted Treatment
4、金屬離子的檢測方法
5、納米材料或微納器件的顯微重複定位方法

吳愛國研究項目

1、Fe3O4·TiO2複合納米粒子在乳腺癌細胞中磁共振造影增強及輔助性治療作用的研究 NSFC面上項目
2、先進環境監測技術設備—重金屬污染環境連續監測技術設備研製 863項目
3、納米金比色法快速檢測重金屬污染離子研究 浙江省傑出青年基金項目
4、核殼磁-光納米材料在乳腺癌早期診斷和靶向治療上的應用研究 中國科學院院長特別資助項目
5、納米醫學造影材料實驗室 企業橫向合作項目

吳愛國榮譽獎勵

2001年獲中科院彭蔭剛冠名獎
2011年獲浙江省傑出青年基金
2011年寧波市領軍與拔尖人才
2012年中科院戰略領域專家（生物醫藥類）
2012年浙江省特聘專家
2013，浙江省領軍人才
2014，中國分析測試協會科學技術獎（CAIA獎）特等獎（排名第二）
2014，浙江省151人才（第二層次）
2016，寧波市領軍和拔尖人才培養工程（第一層次）
2016，寧波市科技進步一等獎
2017，所長特別獎三等獎/優秀團隊獎
2024年5月27日，當選2024國際生物材料科學與工程學會聯合會“生物材料科學與工程Fellow”。 [5] 

吳愛國會員身份

中國納米生物物理專業委員會委員
中科院百人學者理事會理事
中國生物材料學會會員
中國生物物理學會會員
中國化學會會員
美國化學會會員
美國顯微學會會員 [4] 
參考資料