刘东，男，教授，博士生导师 [1]。南通大学教育部神经再生重点实验室教授 [2]，生命科学学院副院长 [3]。
2011年获德国马克斯-德尔布吕克分子医学中心（Max-Delbrück Center for Molecular Medicine）/柏林自由大学（Free University of Berlin）自然科学博士学位。 [2]从2012年起先后任神经再生重点实验室讲师、副教授、教授。中国解剖学会再生医学专业委员会委员，中国生物物理学会听觉分会委员，青年委员会常务委员，江苏省发育与细胞学会理事，江苏省神经科学会理事，江苏省发育生物学会听觉科学专业委员会副主任委员，江苏省神经科学会青年委员会委员。
- 中文名
- 刘东
- 职 业
- 教师
- 职 务
- 博士生导师
- 职 称
- 教授
- 性 别
- 男
所获荣誉
播报编辑
江苏省杰出青年基金获得者、江苏省第五期“333高层次人才培养工程”培养对象、江苏省“六大人才高峰”高层次兰乎才充人才培养对象、获江苏省“双创计划”资助。他是美国心脏协会American Heart Association会员，中国解剖学会再生医学专业委员会委员，中国生物物理学会听觉分会委员格背，青年委员会常务委员。近三年来发表SCI论文30篇，累计影响因子超过130，连拘霉其中以劝旬辣通元习讯作者发表SCI 论文20篇抹纸甩，其中包括知名杂志CardiovascularResearch、Cell Research和On照巩榆cogene等。近5年来以项目主持人身份获得共10项国家级、省部级科研以及凝夜蜜人才项目资助。 [1]
主讲课程
播报编辑
研究生《高级分子生物学》 [2]
科学研究
播报编辑
研究方向
刘东教授照片2、神经发育以及相关疾病的发病机制
3、基于血管内皮细胞、毛细胞和运动神经元行为的化合物筛选 [1-2]
在研课题
2016-2019: 国家自然科学基金-面上项目：血管新生的遗传调控
2013-2015: 国家自然科学基金-青年项目：血管新生的遗传调控
2017-2020: 江苏省高校自然科学研究项目-重大项目：血管新生
2016-2019: 江苏省“六大人才高峰”高层次人才培养对象：血管新生
2014-2016: 江苏省“双创计划”博士计划，境外世界名校创新类计划
2012-2014: 江苏省高校自然科学研究项目-面上项目：血管新生 [1]
研究成果
2016年11月11日，南通大学刘东课题组在国际著名学术刊物《细胞研究》（Cell Research, Doi: 10.1038/cr.2016.134）发表研究论文 [4]，报告了他们将NgAgo基因技术用于斑马鱼的研究结果。在这项研究中，研究人员将NgAgo基因技术用于改变斑马鱼的基因fabp11a（Fattyacid binding protein 11a，脂肪酸结合蛋白11a），结果发现，这可以“敲低”该基因，并因此导致斑马鱼眼部发育缺陷。但是在学术上，“敲低”基因并不等于“编辑”基因，这项研究并没有发现NgAgo技术有基因编辑功能。研究人员同时表示，由于研究对象不同，此次研究“不能对此前韩春雨此前提出的基因编辑手段NgAgo的结论证实或证伪”。 [5-6]
代表论文
J. Qi, Z. Dong, Y. Shi, X. Wang, Y. Qin, Y. Wang,D. Liu,NgAgo-based fabp11a gene knockdown causes eye developmental defects in zebrafish, Cell Research,2016,doi.10.1038/cr.2016.134. [4]
研究论文
1.Zhang, K., Zhang,H., Zhou, H., Crookes, D., Li, L., Shao, Y., and Liu, D. (2019) ZebrafishEmbryo Vessel Segmentation Using a Novel Dual ResUNet Model.Comput Intell Neurosci2019, 8214975
2.Shi, Y., Duan, X.,Xu, G., Wang, X., Wei, G., Dong, S., Xie, G., and Liu, D. (2019) A ribosomalDNA-hosted microRNA regulates zebrafish embryonic angiogenesis.Angiogenesis
3.Qin, Y., Wang, S.,Duan, X., and Liu, D. (2019) Expression analysis of the aquaporins duringzebrafish embryonic development.Geneexpression patterns : GEP32,38-43
4.Dong, Z., Wu, S.,Zhu, C., Wang, X., Li, Y., Chen, X., Liu, D., Qiang, L., Baas, P. W., and Liu,M. (2019) Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth duringneuronal development and regeneration in zebrafish.Traffic20, 71-81
5.Yan, W., Liu, W.,Qi, J., Fang, Q., Fan, Z., Sun, G., Han, Y., Zhang, D., Xu, L., Wang, M., Li,J., Chen, F., Liu, D., Chai, R., and Wang, H. (2018) A Three-Dimensional CultureSystem with Matrigel Promotes Purified Spiral Ganglion Neuron Survival andFunction In Vitro.Molecular neurobiology55, 2070-2084
6.Shan, Y., You, B.,Shi, S., Shi, W., Zhang, Z., Zhang, Q., Gu, M., Chen, J., Bao, L., Liu, D., andYou, Y. (2018) Hypoxia-Induced Matrix Metalloproteinase-13 Expression inExosomes from Nasopharyngeal Carcinoma Enhances Metastases.Cell Death Dis9, 382
7.Li, B., Yu, L., Liu,D., Yang, X., Zheng, Y., Gui, Y., and Wang, H. (2018) MIB1 Mutations ReduceNotch Signaling Activation and Contribute to Congenital Heart Disease.Clin Sci (Lond)
8.Gong, J., Chai, L.,Xu, G., Ni, Y., and Liu, D. (2018) The expression of natriuretic peptidereceptors in developing zebrafish embryos.Geneexpression patterns : GEP29,65-71
9.Dong, Z., Wu, S.,Zhu, C., Wang, X., Li, Y., Chen, X., Liu, D., Qiang, L., Baas, P. W., and Liu,M. (2018) Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth duringneuronal development and regeneration in zebrafish.Traffic
10.Bao, L., You, B.,Shi, S., Shan, Y., Zhang, Q., Yue, H., Zhang, J., Zhang, W., Shi, Y., Liu, Y.,Wang, X., Liu, D., and You, Y. (2018) Metastasis-associated miR-23a fromnasopharyngeal carcinoma-derived exosomes mediates angiogenesis by repressing anovel target gene TSGA10.Oncogene37, 2873-2889
11.Zhang, J., Qi, J.,Wu, S., Peng, L., Shi, Y., Yang, J., Yin, Z., Gao, Y., Wang, C., Gong, J.,Zhang, H., Zhang, J., and Liu, D. (2017) Fatty Acid Binding Protein 11a IsRequired for Brain Vessel Integrity in Zebrafish.Frontiers in physiology8,214
12.Xie, Y., Wang, D.,Lan, F., Wei, G., Ni, T., Chai, R., Liu, D., Hu, S., Li, M., Li, D., Wang, H.,and Wang, Y. (2017) An episomal vector-based CRISPR/Cas9 system for highlyefficient gene knockout in human pluripotent stem cells.Scientific reports7,2320
13.Wang, F., Liu, D.,Zhang, R. R., Yu, L. W., Zhao, J. Y., Yang, X. Y., Jiang, S. S., Ma, D., Qiao,B., Zhang, F., Jin, L., Gui, Y. H., and Wang, H. Y. (2017) A TBX5 3'UTR variantincreases the risk of congenital heart disease in the Han Chinese population.Cell discovery3, 17026
14.Mu, Z., Zhang, S.,He, C., Hou, H., Liu, D., Hu, N., and Xu, H. (2017) Expression of SoxCTranscription Factors during Zebrafish Retinal and Optic Nerve Regeneration.Neuroscience bulletin33, 53-61
15.Lv, F., Zhu, C., Yan,X., Wang, X., and Liu, D. (2017) Generation of a mef2aa:EGFP transgeniczebrafish line that expresses EGFP in muscle cells.Fish physiology and biochemistry43, 287-294
16.Jin, D., Zhu, D.,Fang, Y., Chen, Y., Yu, G., Pan, W., Liu, D., Li, F., and Zhong, T. P. (2017)Vegfa signaling regulates diverse artery/vein formation in vertebratevasculatures.Journal of genetics andgenomics = Yi chuan xue bao44,483-492
17.He, Z., Guo, L., Shu,Y., Fang, Q., Zhou, H., Liu, Y., Liu, D., Lu, L., Zhang, X., Ding, X., Liu, D.,Tang, M., Kong, W., Sha, S., Li, H., Gao, X., and Chai, R. (2017) Autophagyprotects auditory hair cells against neomycin-induced damage.Autophagy, 1-21
18.He, Y., Lu, X., Qian,F., Liu, D., Chai, R., and Li, H. (2017) Insm1a Is Required for ZebrafishPosterior Lateral Line Development.Frontiersin molecular neuroscience10,241
19.Gong, J., Wang, X.,Zhu, C., Dong, X., Zhang, Q., Wang, X., Duan, X., Qian, F., Shi, Y., Gao, Y.,Zhao, Q., Chai, R., and Liu, D. (2017) Insm1a Regulates Motor NeuronDevelopment in Zebrafish.Frontiers inmolecular neuroscience10, 274
20.Zhang, S., Mu, Z.,He, C., Zhou, M., Liu, D., Zhao, X. F., Goldman, D., and Xu, H. (2016)Antiviral Drug Ganciclovir Is a Potent Inhibitor of the Proliferation of MullerGlia-Derived Progenitors During Zebrafish Retinal Regeneration.Investigative ophthalmology & visualscience57, 1991-2000
21.Wang, X., Yuan, W.,Wang, X., Qi, J., Qin, Y., Shi, Y., Zhang, J., Gong, J., Dong, Z., Liu, X.,Sun, C., Chai, R., Le Noble, F., and Liu, D. (2016) The somite-secreted factorMaeg promotes zebrafish embryonic angiogenesis.Oncotarget7,77749-77763
22.Wang, X., Ling, C.C., Li, L., Qin, Y., Qi, J., Liu, X., You, B., Shi, Y., Zhang, J., Jiang, Q.,Xu, H., Sun, C., You, Y., Chai, R., and Liu, D. (2016) MicroRNA-10a/10brepresses a novel target gene mib1 to regulate angiogenesis.Cardiovascular research110, 140-150
23.Shi, Y. W., Yuan, W.,Wang, X., Gong, J., Zhu, S. X., Chai, L. L., Qi, J. L., Qin, Y. Y., Gao, Y.,Zhou, Y. L., Fan, X. L., Ji, C. Y., Wu, J. Y., Wang, Z. W., and Liu, D. (2016)Combretastatin A-4 efficiently inhibits angiogenesis and induces neuronalapoptosis in zebrafish.Scientificreports6, 30189
24.Qi, J., Dong, Z.,Shi, Y., Wang, X., Qin, Y., Wang, Y., and Liu, D. (2016) NgAgo-based fabp11agene knockdown causes eye developmental defects in zebrafish.Cell research26, 1349-1352
25.He, Z., Zhang, S.,Song, Q., Li, W., Liu, D., Li, H., Tang, M., and Chai, R. (2016) The structuraldevelopment of primary cultured hippocampal neurons on a graphene substrate.Colloids and surfaces. B, Biointerfaces146, 442-451
26.Wang, X., Wang, X.,Yuan, W., Chai, R., and Liu, D. (2015) Egfl6 is involved in zebrafish notochorddevelopment.Fish physiology andbiochemistry41, 961-969
27.Wang, X., Chong, M.,Wang, X., Wang, H., Zhang, J., Xu, H., Zhang, J., and Liu, D. (2015) Block thefunction of nonmuscle myosin II by blebbistatin induces zebrafish embryo cardiabifida.In vitro cellular &developmental biology. Animal51,211-217
28.Xu, M., Liu, D.,Dong, Z., Wang, X., Wang, X., Liu, Y., Baas, P. W., and Liu, M. (2014)Kinesin-12 influences axonal growth during zebrafish neural development.Cytoskeleton71, 555-563
29.Wang, X., Li, L., andLiu, D. (2014) Expression analysis of integrin beta1 isoforms during zebrafishembryonic development.Gene expressionpatterns : GEP16, 86-92
30.Sang, Q., Zhang, J.,Feng, R., Wang, X., Li, Q., Zhao, X., Xing, Q., Chen, W., Du, J., Sun, S.,Chai, R., Liu, D., Jin, L., He, L., Li, H., and Wang, L. (2014) Ildr1b isessential for semicircular canal development, migration of the posteriorlateral line primordium and hearing ability in zebrafish: implications for arole in the recessive hearing impairment DFNB42.Human molecular genetics23,6201-6211
31.Li, S., Liu, Q.,Wang, Y., Gu, Y., Liu, D., Wang, C., Ding, G., Chen, J., Liu, J., and Gu, X.(2013) Differential gene expression profiling and biological process analysisin proximal nerve segments after sciatic nerve transection.PLoS One8, e57000
32.Jiang, Q.,Lagos-Quintana, M.,Liu, D., Shi,Y., Helker, C., Herzog, W., and le Noble, F. (2013) miR-30a regulates endothelialtip cell formation and arteriolar branching.Hypertension62, 592-598
33.Huang, Y., Wang, X.,Xu, M., Liu, M., andLiu, D.(2013)Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonicdevelopment.Gene expression patterns :GEP13, 265-270
中文核心期刊：
1.高煜，刘家辉，王新，刘东，斑马鱼遗传操作进展，生物工程学报，2017, 33(10): 1674-1692 (通讯作者)
2.张晶晶，王新，刘东，C型利钠肽基因调控斑马鱼胚胎血管发育，生理学报，2017, 69(1): 11–16 (通讯作者)
3.吕峰，石运伟，王新，刘东，严兴洪，microRNA-10a/b通过抑制Mib1调节斑马鱼神经元的发育，中国细胞生物学学报，2017, 39(2): 191–196 (通讯作者)
4.王鸿奎，王学谦，王新，袁玮，刘东，非肌性肌球蛋白II-B调节斑马鱼咽弓的发育,解剖学报，2016, 47(1):113-116 (通讯作者)
5.袁玮，浦超，Rupesh Puri，石运伟，王新，李石营，刘东，Non-muscle Myosin II-A调节斑马鱼胚胎发育过程中肠内分泌细胞的极化，中国细胞生物学报，2015, 37(3): 328–334 (通讯作者)
6.王新，张素珍，王学谦，李丽萍，张晶晶，刘东，流式细胞仪分选转基因斑马鱼胚胎荧光标记细胞的一种快速方法，中国细胞生物学报，2014, 36(3): 356–360 (通讯作者) [1]
- 1.
- 2.
