劉建釗

2006年畢業於浙江大學高分子科學與工程學系獲得學士學位；

2011年畢業於香港科技大學化學系獲得博士學位；

2011-2012年 香港科技大學化學系從事博士後工作；

2012-2015年 芝加哥大學化學系從事博士後研究工作；

2015年6月-2020年12月 浙江大學百人計劃研究員；

2021年1月起 浙江大學高分子科學與工程學系長聘教授 ^[1] 

· 生物大分子核酸化學修飾及標記

· 信使RNA m6A甲基化機理研究

· 熒光生物探針及顯影 ^[1] 

高分子專業英語 ^[1] 

1.生物大分子RNA化學修飾及其生物學意義

遺傳信息的傳遞是通過DNA轉錄成RNA, 再由RNA翻譯成蛋白質。表觀遺傳學表明DNA和組蛋白上的化學修飾（尤其是甲基化）能調控基因的表達，影響細胞的生物學功能，該方面的知識已寫入教科書。然而，在中心法則中間層次RNA上的化學修飾如何影響基因的表達，是當代化學家和生物學家正在積極探索的前沿科學問題。 目前課題組正在開展的相關研究：結合有機化學、高分子化學以及生物化學等交叉學科手段合成定點鹼基化學修飾的信使RNA（圖1），用於RNA化學修飾功能研究和基因轉染以及治療；信使RNA N6-腺嘌呤甲基化酶複合物表徵及其在細胞內選擇性修飾信使RNA的機理研究（圖2）；研究信使RNA N6-腺嘌呤甲基化酶參與的細胞代謝與信號通路。 ^[1] 

(27) A unimolecular theranostic system with H2O2-specific response and AIE-activity for doxorubicin releasing and real-time tracking in living cells

Gao, X. Y. ; Cao, J. ; Song, Y. N. ; Shu, X. ; Liu, J. Z.*; Sun, J. Z. ; Liu, B.* ; Tang, B. Z*. RSC Advances. 2018, 8, 10975-10979.

(26) VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yue Y.#; Liu, J.#; Cui, X.#; Cao, J.#; Luo, G.; Zhang, Z.; Cheng, T.; Gao, M.; Shu, X.; Ma, H.; Wang, F.; Wang, X.; Shen, B.; Wang, Y.; Feng, X.; He, C.*& Liu, J. Z*.Cell Discovery, 2018, 4, 10. (#contributed equally)

(25) N6-Allyladenosine: a New Small Molecule for RNA Labeling Identified by Mutation Assay

Shu, X.#; Dai, Q.#; Wu, T.#; Bothwell, I. R.; Yue, Y.; Zhang, Z.; Cao, J.; Fei, Q.; Luo, M.; He, C*.; Liu, J. Z*.J. Am. Chem. Soc. 2017,139 (48), 17213–17216 (#contributed equally)

(24) A Two-Channel Responsive Fluorescent Probe with AIE Characteristics and Its Application for Selective Imaging of Superoxide Anions in Living Cells

Gao, X,Y.; Feng, G.; Manghnani, P. N.; Hu, F.; Jiang, N.; Liu, J. Z.; Liu, B*.; Sun, J. Z*.; Tang, B. Z*. Chem. Commun. 2017, 53, 1653-1656.

(23) Abundant DNA 6mA Methylation during Early Embryogenesis of Zebrafish and Pig. Liu, J. Z.#;; Zhu, Y.#;; Luo, G. Z.#;; Wang, X. X.#;; Yue, Y. N.; Wang, X. N.; Zong, X.; Chen, K.; Yin, H.; Fu, Y.; Han, D. L.; Wang, Y. Z*.; Chen, D. H*.; He, C*. Nat. Commun. 2016, 7, 13052. (#;contributed equally)

(22) Characterization of Eukaryotic DNA N6-Methyladenine by a Highly Sensitive estriction Enzyme-Assisted Sequencing

Luo, G. Z.; Wang, F.; Weng, X. C.; Chen, K.; Hao, Z. Y.; Yu, M.; Deng, X.; Liu, J. Z.; He, C.; Nat. Commun. 2016, 7, 11301.

(21) N6-Methyladenine DNA Modification in Drosophila

Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J. Z.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D. Cell. 2015, 161, 893-906.

(20) DNA Methylation on N6-Adenine in C. elegans

Greer, Eric L.; Blanco, Mario A.; Gu, L.; Sendinc, E.; Liu, J. Z.; Aristizábal-Corrales, D.; Hsu, C.-H.; Aravind, L.; He, C.; Shi, Y. Cell 2015, 161, 868-878.

(19) N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas

Fu, Y.; Luo, G.-Z.; Chen, K.; Deng, X.; Yu, M.; Han, D.; Hao, Z.; Liu, J. Z.; Lu, X.; Doré, Louis C.; Weng, X.; Ji, Q.; Mets, L.; He, C. Cell 2015, 161, 879-892.

(18) RNA N6-Methyladenosine Methylation in Post-transcriptional Gene Expression Regulation

Yue, Y.#;; Liu, J. Z.#;; He, C. Genes Dev. 2015, 29, 1343-1355.

(17) A METTL3-METTL14 Complex Mediates Mammalian Nuclear RNA N-6-Adenosine Methylation

Liu, J. Z.#;;Yue, Y.#;; Han, D.; Wang, X.; Fu, Y.; Zhang, L.; Jia, G.; Yu, M.; Lu, Z.; Deng, X.; Dai, Q.; Chen, W.; He, C. Nat. Chem. Biol. 2014, 10, 93-95 (#;;contributed equally).

(16) A Protein Engineered to Bind Uranyl Selectively and with Femtomolar Affinity

Zhou, L.; Bosscher, M.; Zhang, C.; Özçubukçu, S.; Zhang, L.; Zhang, W.; Li, C. J.; Liu, J. Z.; Jensen, M. P.; Lai, L.; He, C. Nat. Chem. 2014, 6, 236-241.

(15) Direct Visualization of Surface-Assisted Two-Dimensional Diyne Polycyclotrimerization

Zhou, H.#;; Liu, J. Z.#;; Du, S.#;; Zhang, L.; Li, G.; Zhang, Y.; Tang, B. Z.; Gao, H. J. Am. Chem. Soc. 2014, 136, 5567-5570 (#;;contributed equally).

(14) Full-Range Intracellular pH Sensing by an Aggregation-Induced Emission-Active Two-Channel Ratiometric Fluorogen

Chen, S.; Hong, Y.; Liu, Y.; Liu, J. Z.; Leung, C. W. T.; Li, M.; Kwok, R. T. K.; Zhao, E.; Lam, J. W. Y.; Yu, Y.; Tang, B. Z. J. Am. Chem. Soc. 2013, 135, 4926-4929.

(13) Real-Time Monitoring of Cell Apoptosis and Drug Screening Using Fluorescent Light-up Probe with Aggregation-Induced Emission Characteristics

Shi, H.; Kowk, R. T. K.; Liu, J. Z.; Xing, B.; Tang, B. Z.; Liu, B. J. Am. Chem. Soc. 2012, 34, 17972-17981.

(12) Specific Detection of Integrin αvβ3 by Light-up Bioprobe with Aggregation-Induced Emission Characteristics

Shi, H.; Liu, J. Z.; Geng, J.; Tang, B. Z.; Liu, B. J. Am. Chem. Soc. 2012, 134, 9569-9572.

(11) Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics

Hong, Y.; Meng, L.; Chen, S.; Leung, C. W. T.; Da, L.; Mahtab, F.; Silva Manzano, D.; Liu, J. Z.; Lam, J. W. Y.; Huang, X.; Tang, B. Z. J. Am. Chem. Soc. 2012, 134,1680-1689.

(10) What Makes Efficient Circularly Polarized Luminescence in Condensed Phase: Aggregation-Induced Dichroism and Light Emission

Liu, J. Z.; Su, H.; Meng, L.; Zhao, Y.; Deng, C.; Ng, J. C. Y.; Lu, P.; Faisal, M.; Lam, J. W. Y.; Huang, X.; Wu, H.; Wong, K. S.; Tang, B. Z. Chem. Sci. 2012, 3, 2737-2747.

(9) An AIE-Active Hemicyanine Fluorogen with Stimuli-Responsive Red/Blue Emission: Extending the pH Sensing Range by “Switch + Knob” Effect

Chen, S.#;; Liu, J. Z.#;; Liu, Y.; Su, H.; Hong, Y.; Jim, C. K. W.; Kwok, R. T. K.; Zhao, N.; Qin, W.; Lam, J. W. Y.; Wong, K. S.; Tang, B. Z. Chem. Sci. 2012, 3, 1804-1809 (#;contributed equally).

(8) Deciphering Mechanism of Aggregation-Induced Emission (AIE): Is E–Z Isomerization Involved in an AIE Process?

Tseng, N.#;; Liu, J. Z.#;; Ng, J. C. Y.; Lam, J. W. Y.; Sung, H. Y.; Williams, I. D.; Tang, B. Z. Chem. Sci. 2012, 3, 493-497 (#;contributed equally).

(7) A New Polymerization Route to Conjugated Polymers: Regio- and Stereoselective Synthesis of Linear and Hyperbranched Poly(arylene chlorovinylene)s by Decarbonylative Polyaddition of Aroyl Chlorides and Alkynes

Liu, J. Z.; Deng, C.; Tseng, N. W.; Chan, C. Y. K.; Yue, Y.; Ng, J. C. Y.; Lam, J. W. Y.; Hong, Y.; Wang, J.; Faisal, M.; Sung, H. H. Y.; Williams, I. D.; Tang, B. Z. Chem. Sci. 2011, 2, 1850-1859.

(6) Thiol-Yne Click Polymerization: Regio- and Stereoselective Synthesis of Sulfur-Rich Acetylenic Polymers with Controllable Chain Conformations and Tunable Optical Properties

Liu, J. Z.; Lam, J. W. Y.; Jim, C. K. W.; Ng, J. C. Y.; Shi, J.; Su, H.; Yeung, K. F.; Hong, Y.; Faisal, M.; Yu, Y.; Wong, K. S.; Tang, B. Z. Macromolecules 2011, 44, 68-79.

(5) Hyperbranched Conjugated Polysiloles: Synthesis, Structure, Aggregation-Enhanced Emission, Multicolor Fluorescent Photopatterning, and Superamplified Detection of Explosives

Liu, J. Z.; Zhong, Y.; Lam, J. W. Y.; Lu, P.; Hong, Y.; Yu, Y.; Yue, Y.; Faisal, M.; Sung, H. H. Y.; Williams, I. D.; Wong, K. S.; Tang, B. Z. Macromolecules 2010, 43, 4921-4936.

(4) A Superamplification Effect in the Detection of Explosives by a Fluorescent Hyperbranched Poly(silylenephenylene) with Aggregation-Enhanced Emission Characteristics

Liu, J. Z.; Zhong, Y.; Lu, P.; Hong, Y.; Lam, J. W. Y.; Faisal, M.; Yu, Y.; Wong, K. S.; Tang, B. Z. Polym. Chem. 2010, 1, 426-429.

(3) Acetylenic Polymers: Syntheses, Structures, and Functions

Liu, J. Z.; Lam, J. W. Y.; Tang, B. Z. Chem. Rev. 2009, 109, 5799-5867.

(2) Exploration of Effective Catalysts for Diyne Polycyclotrimerization, Synthesis of an Ester-Functionalized Hyperbranched Polyphenylene, and Demonstration of Its Utility as a Molecular Container with Implication for Controlled Drug Delivery

Liu, J. Z.; Zhang, L.; Lam, J. W. Y.; Jim, C. K. W.; Yue, Y.; Deng, R.; Hong, Y.; Qin, A.; Sung, H. H. Y.; Williams, I. D.; Jia, G.; Tang, B. Z. Macromolecules 2009, 42, 7367-7378.

(1) Hyperbranched Poly(silylenephenylenes) from Polycyclotrimerization of A2-Type Diyne Monomers: Synthesis, Characterization, Structural Modeling, Thermal Stability, and Fluorescent Patterning

Liu, J. Z.; Zheng, R.; Tang, Y.; Häussler, M.; Lam, J. W. Y.; Qin, A.; Ye, M.; Hong, Y.; Gao, P.; Tang, B. Z. Macromolecules 2007, 40, 7473-7486. ^[1] 

(1) Liu, J. Z.; Lam, J. W. Y.; Tang, B. Z. “Synthesis and Functionality of Substituted Polyacetylenes” In Design and Synthesis of Conjugated Polymers; Leclerc, X., Morin, X., Eds.; Wiley–VCH: New York; 2010; Chapter 1, pp 1-43.

(2) Liu, J. Z.; Lam, J. W. Y.; Tang, B. Z. “Functional Hyperbranched Polymers Constructed from Acetylenic An-Type Building Blocks” In Conjugated Polymer Synthesis–Methods and Reactions; Chujo, Y., Ed.; Wiley–VCH: New York, 2010; Chapter 4, pp 91-131.

(3) Liu, J. Z. Lam, J. W. Y.; Tang, B. Z. “Acetylenic Polymers” In Encyclopedia of Polymer Science and Technology; 4th Ed.; John Wiley & Sons, Inc.: New Jersey, 2011; Vol. 1, pp 1-42.

(4) Liu, J. Z.; Lam, J. W. Y.; Tang, B. Z. “AIE Materials Towards Efficient Circularly Polarized Luminescence, Organic Lasing, and Superamplified Detection of Explosives” In Aggregation-Induced Emission: Applications (1st Ed); Tang, B. Z., Qin, A., Eds.; JohnWiley & Sons, Ltd.: New York, 2013; Chapter 5, pp 106-128. ^[1] 

(1) Tang, B. Z.; Jim, C. K. W.; Qin, A.; Lam, J. W. Y.; Liu, J. Z.; “Sulfur-Containing Macromolecules and Methods for Their Preparation”, World Patent WO 2011/020287 A1.

(2) Tang, B. Z.; Qin, W.; Liu, J. Z.; Chen, S.; Liu, B.; Li, K.; Ding, D.; Sun, J.; Qin, A.; Zhao, Q. “Biocompatible Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes and Methods of Using the Same for in Vitro and in Vivo Imaging” World Patent WO 2013/029340 A9.

(3) Tang, B. Z.; Ng, K. M.; Luo, Q.; Yu, Y.; Hong, Y.; Liu, J. Z.; Chen, S.; Lam, J. W. Y. “Aggregation Induced Emission Active Cytophilic Fluorescent Bioprobes for Long-Term Cell Tracking”US Patent US 2013/0089889 A1.

(4) Tang, B. Z.; Lam, J. W. Y.; Liu, J. Z.; Mahtab, F. “Silica Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes for Intracellular Imaging and Protein Carrier” US Patent US 20130210047 A1. ^[1] 

2015年浙江大學百人計劃獲得者；

2017年獲得科技部國家重點研發計劃“蛋白質機器與生命過程調控”重點專項青年科學家項目。 ^[1]