反饋

劉小華

（四川大學化學學院教授）

劉小華，女，1977年11月出生，女，湖北隨州人，四川大學化學學院教授，博士生導師。

2011年獲教育部新世紀優秀人才支持計劃資助，2012年獲國家優秀青年科學基金資助，2015年入選國家“萬人計劃”青年拔尖人才計劃，享國務院政府特殊津貼，2016年獲國家傑出青年科學基金資助，2017年入選國家百千萬人才工程，2018年入選四川省學術和技術帶頭人。

中文名: 劉小華
國籍: 中國

學位/學歷: 理學博士
職業: 教師
職稱: 四川大學化學學院教授

劉小華人物履歷

1996年－2000年於湖北師範學院化學系學習，獲理學學士學位。

2000年－2003年於四川大學化學學院分析化學專業學習，獲理學碩士學位。

2003年－2006年於四川大學化學學院有機化學專業學習，獲理學博士學位。

2006年－2010年，四川大學化學學院副教授，碩士生導師。

2010年－至今，四川大學化學學院教授，2012年擔任博士生導師。

劉小華主要研究方向

主要從事不對稱合成方法學及生理活性化合物的合成研究。^[3] 研究工作集中在新型手性雙功能胍-酰胺和胺類配體和催化劑的設計合成，基於雙活化策略、胍基的鹼性及氫鍵活化模式，在温和條件下，高效高選擇性地實現了多個不對稱催化反應。

劉小華主要成就

發展了一系列新型胍-酰胺雙功能手性小分子催化劑；創新性地將手性胍-酰胺作為配體用於金屬配合物手性催化。以第一作者或通訊作者在Acc. Chem. Res.,Chem. Soc. Rev., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nat. Commun., Chem等國際核心化學學術刊物上發表SCI論文90餘篇。作為第二完成人獲2012年國家自然科學獎二等獎和2009年教育部自然科學獎一等獎。獲第十五屆中國青年女科學家獎、第六屆中國化學會—英國皇家化學會青年化學獎、全國性基金獎勵霍英東青年教師獎、Asian Core Program/Advanced Research Network Lectureship Award和德國Thieme Chemistry Journals Award。^[2]

劉小華學術兼職

任中國化學會青年化學工作者委員會、手性化學專業委員會和物理有機化學專業委員會委員，任中國化學快報、化學學報、高等學校化學學報編委。

劉小華代表性成果

1. Shunxi Dong, Xiaohua Liu*, Yin Zhu, Peng He, Lili Lin, Xiaoming Feng*, Organocatalytic Oxyamination of Azlactones: Kinetic Resolution of Oxaziridines and Asymmetric Synthesis of Oxazolin-4-ones, J. Am. Chem. Soc. 2013, 135, 10026-10029.

2. Jing Wang, Xiaohua Liu*, Shunxi Dong, Lili Lin, Xiaoming Feng*, Asymmetric Organocatalytic Cyclopropanation of Cinnamone Derivatives with Stabilized Sulfonium Ylides, J. Org. Chem. 2013, 78, 6322-6327.

3. Zhenling Chen, Lili Lin, Min Wang, Xiaohua Liu*, Xiaoming Feng*, Asymmetric Synthesis of trans-β-Lactams by a Kinugasa Reaction on Water, Chem. Eur. J. 2013, 19, 7561–7567.^[4]

4. Min Wang, Xiaohua Liu*, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 1,2,4-Triazolines by Chiral Iron(II)-Complex Catalyzed Cyclization of α-Isocyano Esters and Azodicarboxylates, Chem. Commun. 2013, 49, 2572–2574.

5. Yang Yang, Shunxi Dong, Xiaohua Liu*, Lili Lin, Xiaoming Feng*, Chiral Guanidine-Catalyzed Asymmetric Direct Vinylogous Michael Reaction of α,β-Unsaturated γ-Butyrolactams with Alkylidene Malonates, Chem. Commun. 2012, 48, 5040–5042.

6. Yangbin Liu, Xiaohua Liu*, Min Wang, Peng He, Lili Lin, Xiaoming Feng*, Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones, J. Org. Chem. 2012, 77, 4136–4142.

7. Xiao Xiao, Xiaohua Liu*, Shunxi Dong, Yunfei Cai, Lili Lin, Xiaoming Feng*, Asymmetric Synthesis of 2,3-Dihydroquinolin-4-one Derivatives Catalyzed by Chiral Bisguanidium Salt, Chem. Eur. J. 2012, 18, 15922–15925.

8. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Chiral N,N'-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions, Acc. Chem. Res. 2011, 44, 574–587.

9. Shunxi Dong, Xiaohua Liu*, Yulong Zhang, Lili Lin, and Xiaoming Feng*, Asymmetric Synthesis of 3,4-Diaminochroman-2-ones Promoted by Guanidine and Bisguanidium Salt, Org. Lett. 2011, 13, 5060–5063.

10. Jing Wang, Wentao Wang, Xiaohua Liu*, Zongrui Hou, Lili Lin, Xiaoming Feng*, Highly Enantioselective Direct Michael Addition of 1H-Benzotriazole to Chalcones Catalyzed by Sc(OTf)3/N,N-Dioxide Complex, Eur. J. Org. Chem. 2011, 2039–2042.

11. Xiaohong Chen, Shunxi Dong, Zhen Qiao, Yin Zhu, Mingsheng Xie, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Guanidine Organocatalyst for the Asymmetric Mannich-Type Reaction between α-Isothiocyanato Imide and Sulfonyl Imines, Chem. Eur. J. 2011, 17, 2583–2586.

12. Min Wang, Lili Lin, Jian Shi, Xiaohua Liu*, Yulong Kuang, Xiaoming Feng*, Asymmetric Crossed-Conjugate Addition of Nitroalkenes to Enones by a Chiral Bifunctional Diamine Organocatalyst, Chem. Eur. J. 2011, 17, 2365–2368.

13. Peng He, Xiaohua Liu*, Jian Shi, Lili Lin, Xiaoming Feng*, Organocatalytic Sequential Michael Reactions: Stereoselective Synthesis of Multifunctionalized Tetrahydroindan Derivatives, Org. Lett. 2011, 13, 936-939.

14. Zhenhua Dong, Xiaohua Liu*, Juhua Feng, Min Wang, Lili Lin, Xiaoming Feng*, Efficient Asymmetric Synthesis of 4H-Chromene Derivatives through a Tandem Michael Addition– Cyclization Reaction Catalyzed by a Salen–Cobalt(II) Complex, Eur. J. Org. Chem. 2011, 137–142.

15. Xuan Fu, Juhua Feng, Zhenhua Dong, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Enantioselective Synthesis of 2-Substituted-1,5-Benzodiazepines through Domino Reaction of o-Phenylenediamine and Chalcone Derivatives, Eur. J. Org. Chem. 2011, 5233–5236.

16. Yonghai Hui, Weiliang Chen, Wentao Wang, Jun Jiang, Yunfei Cai, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Zinc-Catalyzed Friedel–Crafts Alkylation of Indoles with Ethyl Trifluoropyruvate, Adv. Synth. Catal. 2010, 352, 3174–3178.

17. Lin Zhou, Lili Lin, Wentao Wang, Jie Ji, Xiaohua Liu*, Xiaoming Feng*, Highly Enantioselective Michael Addition of Malonates to β,γ-Unsaturated α-Ketoesters Catalyzed by Chiral N,N'-dioxide-Yttrium(III) Complexes with Convenient Procedure, Chem. Commun. 2010, 46, 3601–3603.

18. Qi Zhang, Yonghai Hui, Xin Zhou, Lili Lin, Xiaohua Liu*, Xiaoming Feng*, Highly Efficient Asymmetric Three-Component Vinylogous Mannich Reaction Catalyzed by a Chiral Scandium(III)-N,N'-Dioxide Complex, Adv. Synth. Catal. 2010, 352, 976–980.

19. Xiaohua Liu, Lili Lin, Xiaoming Feng*, Amide Based Bifunctional Organocatalysts in Asymmetric Reactions (Feature Article), Chem. Commun. 2009, 6145–6158.

20. Xiaohua Liu, Bo Qin, Bin He, and Xiaoming Feng*, Catalytic Asymmetric Cyanosilylation of Ketones by a Chiral Amino Acid Salt, J. Am. Chem. Soc. 2005, 127, 12224-12225.^[5]