劉劍波

2006–2011，湖南大學，分析化學，博士 (導師：王柯敏 教授)

2004–2006，湖南大學，生物醫學工程，碩士 (導師：王柯敏 教授)

2000–2004，湖南大學，化學（應用化學試點班），學士 ^[1] 

2014-至今，湖南大學，化學化工學院，教授

2017-2019，英國布里斯托大學，化學學院，博士後 （導師： Stephen Mann FRS）

2011-2014，湖南大學，化學化工學院，助理研究員 ^[1] 

分析化學：

納米與分子尺度水平上的化學生物分析

化學生物學： ^[1] 

細胞與組織仿生及其生物醫學應用研究

1、國家自然科學基金面上項目，21778016，仿生催化產生一氧化氮的級聯酶組裝體的構建及其抗血栓應用研究，2018/01-2021/12，主持；

2、國家自然科學基金面上項目，21575037，核酸適配體-DNA納米凝膠藥物載體的構建及其腫瘤靶向治療研究，2016/01-2019/12，主持；

3、國家自然科學基金青年基金，21205033，量子點可逆團聚熒光納米探針的構建研究，2013/01-2015/12，主持；

4、化學生物傳感與計量學國家重點實驗室交叉學科前沿研究項目，2020/01-2021/01，主持；

5、湖南省自然科學基金面上項目，2020JJ4168，一氧化氮仿生催化組裝體的構建及其生物效應研究，2020/01-2022/12，主持；

6、湖南省自然科學基金青年項目，2017JJ3026，基於量子點化學鼻陣列圖譜的血清蛋白傳感技術研究，2017/01-2019/12，主持；

7、湖南大學青年教師成長計劃資助，中央高校基本科研業務費，2012/1-2018/12、主持；

8、湖南省重點研發科技計劃項目，2017DK2011，面向早期結直腸癌診治的小鼠T分期原位模型構建及其功能化探針篩選與靶向診療應用研究， 2017/03-2019/12，參與；

9、863計劃，診斷試劑關鍵性原輔材料的研製，2012/04-2016/12，參與；

10、國家自然科學基金重大項目子課題，21190041, 核酸適配體的篩選與分子識別基礎研究，2012/04-2016/12，參與。

[43] Hui Chen, Li Zhou (co-author), Chunying Li, Xiaoxiao He, Jin Huang, Xiaohai Yang, Hui Shi,* Kemin Wang, Jianbo Liu.* Controlled dimerization of artificial membrane receptors for transmembrane signal transduction. Chemical Science, 2021, DOI: 10.1039/D1SC00718A. https://doi.org/10.1039/D1SC00718A

[42] Qiaoshu Chen, Yanwen Zhang, Hui Chen, Jianbo Liu,* Juewen Liu.* Enhancing the sensitivity of DNA and aptamer probes in the Dextran/PEG aqueous two-phase system. Analytical Chemistry, 2021, ASAP. https://doi.org/10.1021/acs.analchem.1c01419

[41] Yu Yao#, Yanwen Zhang (co-author)#, Li Li, Yan Huang, Xiaohai Yang, Zhihong Peng,* Kemin Wang, Jianbo Liu.* Photothermally activated coacervate model protocells as signal transducers endow mammalian cells with light sensitivity. Advanced Biology, 2021, ASAP. DOI:10.1002/adbi.202100695.

[40] Yanwen Zhang, Yufeng Chen, Xiaohai Yang, Xiaoxiao He, Mei Li, Songyang Liu, Kemin Wang, Jianbo Liu*, Stephen Mann.* Giant coacervate vesicles as an integrated approach to cytomimetic modeling. Journal of the American Chemical Society, 2021, 143, 2866−2874. https://doi.org/10.1021/jacs.0c12494

[39] Yufeng Chen, Yanwen Zhang, Mei Li, Songyang Liu, Xiaohai Yang, Kemin Wang, Stephen Mann,* Jianbo Liu.* Self-immobilization of coacervate droplets by enzyme-mediated hydrogelation. Chemical Communications, 2021,57, 5438-5441. https://doi.org/10.1039/D1CC01483H

[38] Qiaoshu Chen, Meiling Jian, Hui Chen, Bing Zhou, Hui Shi, Xiaohai Yang, Kemin Wang, Jianbo Liu.* Design of lipophilic split aptamers as artificial carriers for transmembrane transport of adenosine triphosphate. CCS Chemistry, 2021, 3, 144-153. https://doi.org/10.31635/ccschem.020.202000591

[37] Songyang Liu, Yanwen Zhang, Mei Li, Li Xiong, Zijian Zhang, Xiaohai Yang, Xiaoxiao He, Kemin Wang, Jianbo Liu,* Stephen Mann.* Enzyme-mediated nitric oxide production in vasoactive erythrocyte membrane-enclosed coacervate protocells. Nature Chemistry, 2020, 12, 1165-1173. https://www.nature.com/articles/s41557-020-00585-y

[36] Yanwen Zhang, Songyang Liu, Yu Yao, Yufeng Chen, Shaohong Zhou, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Invasion and defense interactions between enzyme-active liquid coacervate protocells and living cells. Small, 2020, 16, 20020733 (Cover Article).

[35] Yufeng Chen, Min Yuan, Yanwen Zhang, Songyang Liu, Xiaohai Yang, Kemin Wang,* Jianbo Liu.* Construction of coacervate-in-coacervate multicompartment protocells for spatial organization of enzymatic reactions. Chemical Science, 2020, 11, 8617–8625.

[34] Jianbo Liu,* Liangfei Tian, Yan Qiao, Shaohong Zhou, Avinash J. Patil, Kemin Wang, Mei Li,* Stephen Mann.* Hydrogel-immobilized coacervate droplets as modular microreactor assemblies. Angewandte Chemie International Edition, 2020, 59, 6853 – 6859. (Hot paper, Cover Article)

[33] Chunying Li, Hui Chen, Qiaoshu Chen, Hui Shi,* Xiaohai Yang, Kemin Wang, Jianbo Liu.* Lipophilic G-quadruplex isomers as biomimetic ion channels for conformation- dependent selective transmembrane transport. Analytical Chemistry, 2020, 92, 10169–10176.

[32] Qiaoshu Chen, Yibo Liu, Jianbo Liu,* Juewen Liu.* Liposome boosted peroxidase mimicking nanozymes breaking the pH limit. Chemistry - A European Journal, 2020, 26, 16659-16665 (Hot paper).

[31] Yingben Wu,* Yan Liu (co-author), Huizhi Liu, Biao Liu, Wei Chen, Lijuan Xu, Jianbo Liu.* Ion-mediated self-assembly of Cys-capped quantum dots for fluorescence detection of As(III) in water. Analytical Methods, 2020, 12, 4229–4234.

[30] Yan Huang, Haifeng Li, Xiaoxiao He, Xiaohai Yang, Li Li, Songyang Liu, Zhen Zou, Kemin Wang,* Jianbo Liu.* Near-infrared photothermal release of hydrogen sulfide from nanocomposite hydrogels for anti-inflammation applications. Chinese Chemical Letters, 2020, 31, 787-791.

[29] Miaomiao Zhuang, Yanwen Zhang, Shaohong Zhou, Yun Zhang, Kemin Wang, Jinfang Nie,* Jianbo Liu.* Uricase-containing coacervate microdroplets as enzyme active membrane-free protocells for detoxification of uric acid in serum. Chemical Communications, 2019, 55, 13880-13883.

[28] Chunying Li, Hui Chen, Li Zhou, Hui Shi, Xiaoxiao He, Xiaohai Yang,* Kemin Wang, Jianbo Liu.* Single-stranded DNA designed lipophilic G-quadruplexes as transmembrane channels for switchable potassium transport. Chemical Communications, 2019, 55, 12004-12007. (Cover Page)

[27] Haifeng Li, Yu Yao, Hui Shi, Yanli Lei, Yan Huang, Kemin Wang, Xiaoxiao He,* Jianbo Liu.* Near-infrared light-responsive nanocomposite for photothermal release of H2S and suppression of cell viability. Journal of Materials Chemistry B, 2019, 7, 5992-5997.

[26] Qiaoshu Chen, Shaohong Zhou, Chunying Li, Qiuping Guo, Xiaohai Yang, Jin Huang, Jianbo Liu,* Kemin Wang.* DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging. Chemical Communications, 2019, 55, 4242-4245.

[25] Li Li, Gui Li, Xiaoxiao He, Xiaohai Yang, Songyang Liu, Jinlu Tang, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Protein- driven disassembly of surfactant- polyelectrolyte nanomicelles: Modulation of quantum dot/fluorochrome FRET for pattern sensing. Sensors and Actuators B: Chemical, 2018, 272, 393-399.

[24] Li Zhou, Yu Liu, Hui Shi, Xiaohai Yang, Jin Huang, Songyang Liu, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Flexible assembly of an enzyme cascade on a DNA triangle prism nanostructure for the controlled biomimetic generation of nitric oxide. ChemBioChem. 2018, 19, 2099-2106.

[23] Wei Liu, Jue Zhang, Zhihong Peng, Xiaohai Yang, Li Li, Qiaoshu Chen, Jianbo Liu,* Kemin Wang.* Controlled formation of Ag₂S/Ag Janus nanoparticles using alkylamine as reductant surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, 544, 111-117.

[22] Qiaoshu Chen, Chunying Li, Xiaohai Yang, Jin Huang, Songyang Liu, Wei Liu, Jianbo Liu,* Kemin Wang*. Self-assembled DNA nanowires as quantitative dual-drug nanocarriers for antitumor chemophotodynamic combination therapy. Journal of Materials Chemistry B, 2017, 5, 7529-7537.

[21] Yu Liu，Qiaoshu Chen，Xiaohai Yang，Qiuping Guo，Li Li, Jianbo Liu,* Kemin Wang*. Design of modular DNA triangular-prism sensor enabling ratiometric and multiplexed biomolecule detection on single microbead. Analytical Chemistry，2017, 89, 3590−3596.

[20] Xi Guo, Yanwen Zhang, Jianbo Liu,*Xiaohai Yang, Jin Huang, Li Li, Lan Wan, Kemin Wang.* Red blood cell membrane-mediated fusion of hydrophobic quantum dots with living cell membranes for cell imaging. Journal of Materials Chemistry B, 2016, 4, 4191-4197.

[19] Lan Wan, Qiaoshu Chen, Jianbo Liu,* Xiaohai Yang, Jin Huang, Li Li, Xi Guo, Jue Zhang, Kemin Wang* Programmable self-assembly of DNA-protein hybrid hydrogel for enzyme encapsulation with enhanced biological stability. Biomacromolecules, 2016, 17, 1543–1550.

[18] Li Li, Jianbo Liu*, Xiaohai Yang, Jin Huang, Dinggeng He, Xi Guo, Lan Wan, Xiaoxiao He,* Kemin Wang* Biomimetic synthesis of highly biocompatible gold nanoparticles with amino acid-dithiocarbamate as a precursor for SERS imaging. Nanotechnology, 2016, 27, 105603.

[17] Xing Shi, Jue Zhang, Xiaohai Yang, Wei Liu, Li Li, Gui Li, Jianbo Liu,* Kemin Wang* Metallurgical leaching of metal powder for facile and generalized synthesis of metal sulfide nanocrystals. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2016, 497, 344–351

[16] Wei Liu, Xiaohai Yang, Dinggeng He, Leiliang He, Li Li, Yu Liu, Jianbo Liu,* Kemin Wang.* Dopamine modulated ionic permeability in mesoporous silica sphere based biomimetic compartment. Colloids and surfaces B: Biointerfaces, 2016, 142, 266–271.

[15] Jianbo Liu, Haining Ji, Jin Huang, Li Li, Qing Wang, Xiaohai Yang,* Kemin Wang.* Intelligent nucleic acid functionalized dual-responsive gold nanoflare: logic-gate nanodevice visualized by single-nanoparticle imaging. ChemistrySelect, 2016, 1(2), 347 –353

[14] Li Li, Jianbo Liu (co-author), Xiaohai Yang, Zhihong Peng, Wei Liu, Xu Jianguo, Jinglu Tang, Xiaoxiao He,* Kemin Wang.* Quantum dot/ methylene blue FRET mediated NIR fluorescent nanomicelles with large Stocks shift for bioimaging. Chemical Communications, 2015, 51, 14357-14360.

[13] Chunlei Wu, Jianbo Liu (co-author), Pengfei Zhang, Jing Li, Haining Ji, Xiaohai Yang, Kemin Wang* Recognition-before-labeling strategy for sensitive detection of lung cancer cells with quantum dots-aptamer complex. Analyst, 2015,140, 6100-6107.

[12] Wei Liu, Jianbo Liu (co-author), Xiaohai Yang, Kemin Wang,* Qing Wang, Meng Yang, Li Li, Chunxia Song. Phosphate modulated permeability of mesoporous silica spheres: a biomimetic ion channel decorated compartment model. Journal of Materials Chemistry B, 2015, 2015,3, 323-329.

[11] Jianbo Liu, Gui Li, Xiaohai Yang, Kemin Wang,* Li Li, Wei Liu, Xing Shi, Yali Guo. Exciton energy transfer-based quantum dot fluorescence sensing array: “chemical noses” for discrimination of different nucleobases. Analytical Chemistry, 2014, 87, 876-883.

[10] Jianbo Liu, Pengfei Zhang, Xiaohai Yang, Kemin Wang,* Qiuping Guo, Jin Huang, Wei Li. Aptamer-mediated indirect quantum dot labeling and fluorescent imaging of target proteins in living cells. Nanotechnology, 2014, 25, 505502.

[9] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Wei Liu, Dong Wang. Solid-phase single molecule biosensing using dual-color colocalization of fluorescent quantum dot nanoprobes. Nanoscale 2013, 5, 11257-11264.

[8] Jianbo Liu, Yan Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Hui Shi, Li Li. Exciton energy transfer-based fluorescent sensing through aptamer-programmed self-assembly of quantum dots. Analytical Chemistry 2013, 85, 11121-11128.

[7] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Xiaoxiao He, Qing Wang, Jin Huang, Yan Liu. Aggregation control of quantum dots through ion-mediated hydrogen bonding shielding. ACS Nano, 2012, 6, 4973-4983.

[6] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Qing Wang, Haining Ji, Chunlei Wu, Jing Li, Xiaoxiao He, Jinlu Tang, Jin Huang. Combining physical embedding and covalent bonding for stable encapsulation of quantum dots into agarose hydrogels. Journal of Materials Chemistry, 2012, 22, 495-501.

[5] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Yan He, Pengfei Zhang, Haining Ji, Lixin Jian, Wei Liu. Single nanoparticle imaging and characterization of different phospholipid-encapsulated quantum dot micelles. Langmuir, 2012, 28, 10602-10609.

[4] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Ronghua Yang, Haining Ji, Liyan Yang, Chunlei Wu. A switchable fluorescent quantum dot probe based on aggregation/disaggregation mechanism. Chemical Communications, 2011, 47, 935-937.

[3] Jianbo Liu, Xiaohai Yang, Xiaoxiao He, Kemin Wang,* Qing Wang, Qiuping Guo, Hui Shi, Jin Huang, Xiqin Huo. Fluorescent nanoparticles for chemical and biological sensing. Science China-Chemistry, 2011, 54, 1157-1176.

[2] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Dong Wang, Pengfei Zhang. Chemical etching with tetrafluoroborate: a facile method for resizing of CdTe nanocrystals under mild conditions. Chemical Communications, 2009, 6080-6082.

[1] Jianbo Liu, Xiaohai Yang, Kemin Wang,* Weihong Tan, Zhaohui Li, Pengfei Zhang, Dong Wang. Preparation of hydrophobic quantum dots using oleylamine-hydrogen selenide complex as precursor. Chemical Journal of Chinese Universities, 2008, 29, 2516-2520. ^[1]