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周金秋

鎖定
周金秋,男,表觀遺傳學家研究員,研究組長,博士生導師。
現任中國科學院分子細胞科學卓越創新中心副主任,分子生物學國家重點實驗室主任。 [1] 
中文名
周金秋
國    籍
中國
民    族
漢族
畢業院校
南京大學
邁阿密大學
性    別
職    稱
研究員

周金秋人物經歷

周金秋教育經歷

1984-09--1988-06 就讀於南京大學生物系,獲學士學位
1992-08--1997-05 就讀於美國邁阿密大學醫學院生物化學與分子生物學系,獲博士學位 [1-2] 

周金秋工作經歷

1988-07~1992-07,中科院上海生化所, 研究助理
1997-06~1998-05,美國邁阿密大學醫學院, 博士後
1998-07~2001-09,美國普林斯頓大學, 博士後
2001-09~現在, 中科院上海生化細胞所, 研究員 [2] 

周金秋社會兼職

2014-08-01-今,中國生物化學與分子生物學會, 常務理事
2014-01-01-2016-12-31,Journal of Genetics and Genomics, 編委
2013-01-01-今,上海科技大學, 兼職教授
2012-07-01-2017-06-30,Journal of Biological Chemistry, 編委
2011-07-01-2016-06-30,PLoS Genetics, 副主編(Associate Editor)
2009-06-01-今,Journal of Molecular and Cellular Biology, 副主編
2007-01-01-2010-12-31,“Mechanisms of Aging and Development”雜誌的編輯顧問委員會委員,
2003-01-01-今,中國生物化學與分子生物學會理事,
2003-01-01-今,中國遺傳學會理事,
2003-01-01-今,中國細胞生物學會理事,
2002-02-01-2007-01-30,中國科學院與德國馬普學會合作的青年科學家小組組長 [2] 

周金秋科研活動

周金秋科研項目

( 1 ) 幹細胞編程與重編程中表觀遺傳密碼建立和維持的分子機制和結構基礎, 參與, 國家級, 2011-01--2015-08
( 2 ) 組蛋白H4的K5/8/12乙酰化“密碼”的建立和解讀, 主持, 國家級, 2009-01--2012-12
( 3 ) 幹細胞編程與重編程中表觀遺傳密碼建立和維持的分子機制和結構基礎, 參與, 國家級, 2011-01--2015-12
( 4 ) 端粒與染色體穩定性, 主持, 國家級, 2013-01--2017-08
( 5 ) 染色質共價修飾在表觀遺傳調控中的機制研究(表觀遺傳學), 主持, 國家級, 2013-01--2015-12
( 6 ) 端粒異染色質形成的分子基礎, 主持, 國家級, 2013-01--2017-12
( 7 ) 端粒長度的遺傳調控機制, 主持, 國家級, 2014-10--2016-09
( 8 ) 染色質共價修飾在表觀遺傳調控中的機制研究(表觀遺傳學), 主持, 國家級, 2016-01--2018-12
( 9 ) 表觀遺傳調控中關鍵蛋白質機器的結構功能研究, 參與, 國家級, 2016-07--2020-12
( 10 ) 單染色體酵母細胞染色體遺傳機制研究, 主持, 省級, 2018-12--2021-11
( 11 ) 染色體改造單倍體幹細胞的構建及應用, 主持, 國家級, 2019-10--2023-12
( 12 ) 創建單條染色體小鼠研究, 主持, 部委級, 2019-09--2023-12

周金秋參與會議

(1)Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription 第三屆遺傳學和基因組學前沿會議 2017-10-09
(2)KEOPS Complex Affects DNA Double-Strand Break Repair by Promotion DNA End Resection 第十屆中國模式真菌研討會 2017-06-09
(3)Modifications on both sister histone H3s coordinate to regulate chromatin structure and transcription 第十二次全國基因功能與表觀遺傳調控學術研討會 2017-06-01
(4)Asymmetrically modified nucleosomes poise genes for activation or repression 2016年度全國生化大會 2016-10-20
(5)Inhibition of telomere recombination promotes yeast cell longevity 2016-09-09
(6)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 蘇州冷泉港 2016-09-05
(7)Rad6-Bre1 mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection 蘇州冷泉港 2016-09-05
(8)Asymmetrically modified nucleosomes poise genes for activation/repression in yeast 第七屆全國微生物遺傳學學術研討會 2016-08-05
(9)第九屆中國模式真菌研討會 2016-06-17
(10)The KEOPS complex regulates telomere replication and recombination independently of tRNA modification 蘇州冷泉港 2016-06-13
(11)Asymmetrically modified nucleosomes poise gene activation/repression in yeast 蘇州冷泉港 2016-05-09
(12)Inhibition of Telomere Recombination Promotes Cell Longevity 第十五屆美洲華人生物科學學會學術研討會 2015-06-26
(13)第八屆中國模式真菌研討會 2015-06-12
(14)Hmt1 dimer fulfills methylation of histone H3 arginine 2 in trans 第七屆中國模式真菌研討會 李宏韜 2014-05-30
(15)Histone H4 lysine 12 acetylation regulates telomere dynamics in Saccharomyces cerevisiae 染色質與表觀遺傳研討會 Bo Zhou 2010-05-16
(16)The function of Est1p and Est3p in regulation of telomerase activity in Saccharomyces cerevisiae 第66屆日本癌症學會年會 Jinqiu Zhou 2007-10-05 [2] 

周金秋研究方向

染色質與細胞衰老
實驗室的長遠目標是探索真核細胞維持染色體穩定性的機制和細胞衰老的機理。 [1] 

周金秋代表論文

(1) A single circular chromosome yeast, Cell Research, 2019, 通訊作者
(2) Yeast KEOPS complex regulates telomere length independently of its t6A modification function, Nucleic Acids Research, 2019, 通訊作者
(3) Creating a functional single-chromosome yeast, Nature, 2018, 通訊作者
(4) Rad6-Bre1 mediated histone H2Bub1 protects uncapped telomeres from exonuclease Exo1 in Saccharomyces cerevisiae, DNA Repair, 2018, 通訊作者
(5) Tel1 and Rif2 oppositely regulate telomere protection at uncapped telomeres in Saccharomyces cerevisiae, Journal of Genetics and Genomics, 2018, 通訊作者
(6) Rad6–Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection, Nucleic Acids Research, 2017, 通訊作者
(7) MOF as an evolutionarily conserved histone crotonyltransferase and transcriptional activation by histone acetyltransferase- deficient and crotonyltransferase-competent CBP/p300, Cell Discovery, 2017, 第 10 作者
(8) Independent manipulation of histone H3 modifications in individual nucleosomes reveals the contributions of sister histones to transcription, elife, 2017, 通訊作者
(9) Molecular dynamics of de novo telomere heterochromatin formation in budding yeast, Journal of Genetics and Genomics, 2016, 通訊作者
(10) Tethering Telomerase to Telomeres Increases Genome Instability and Promotes Chronological Aging in Yeast, Aging, 2016, 通訊作者
(11) Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity, PloS Genetics, 2015, 通訊作者
(12) Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro, Biochemical Journal, 2015, 通訊作者
(13) Telomere recombination preferentially occurs at short telomeres in telomerase-null type II survivors, PloS One, 2014, 通訊作者
(14) Telomerase-null survivor screening identifies novel telomere recombination regulators, Plos Genetics, 2013, 通訊作者
(15) Characterization of the intramolecular G-quadruplex promoting activity of Est1, FEBS Letters, 2013, 通訊作者
(16) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance, Nucleic Acids Resserch, 2012, 通訊作者
(17) Recent transcription-induced histone H3K4 methylation inhibits gene reactivation, J. Biol. Chem., 2011, 通訊作者
(18) Histone H3 Lysine 4 Hypermethylation Prevents Aberrant Nucleosome Remodeling at the PHO5 Promoter, Molecular Cell Biology, 2011, 通訊作者
(19) Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae, Plos Genetics, 2011, 通訊作者
(20) Est1 Protects Telomeres and Inhibits Subtelomeric Y-Element Recombination, Molecular Cell Biology, 2011, 通訊作者
(21) Yeast telomerase subunit Est1p has guanine quadruplex–promoting activity that is required for telomere elongation, Nature Structural and Molecular Biology, 2010, 通訊作者
(22) SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation, Molecular Cell Biology, 2010, 通訊作者
(23) The N-terminus of histone H3 is required for de novo DNA methylation in chromatin, Proceedings of the National Academy of Sciences, 2009, 通訊作者
(24) Telomere Recombination Accelerates Cellular Aging in Saccharomyces cerevisiae, Plos Genetics, 2009, 通訊作者
(25) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation, Nucleic Acids Research, 2009, 通訊作者
(26) Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication, The EMBO Journal, 2009, 通訊作者
(27) Ten1p promotes the telomeric DNA-binding activity of Cdc13p: implication for its function in telomere length regulation, Cell Research, 2009, 通訊作者
(28) Candida albicans,a distinctive fungal model for cellular aging study, Aging Cell, 2008, 通訊作者
(29) Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3, Nucleic Acids Research, 2006, 通訊作者
(30) Characterization of ATPase Activity of Recombinant Human Pif1, Acta Biochimica et Biophysica Sinica, 2006, 通訊作者
(31) Schizosaccharomyces pombe pfh1 Encodes an Essential 5 to 3 DNA Helicase That Is a Member of the PIF1 Subfamily of DNA Helicases, Molecular Biology of the Cell, 2002, 第 1 作者
(32) Saccharomyces Rrm3p, a 5 to 3 DNA helicase that promotes replication fork progression through telomeric and subtelomeric DNA, Genes and Development, 2002, 第 1 作者
(33) Pif1p Helicase, a Catalytic Inhibitor of Telomerase in Yeast, Science, 2000, 第 1 作者
(34) The Saccharomyces Pif1p DNA Helicase and the Highly Related Rrm3p Have Opposite Effects on Replication Fork Progression in Ribosomal DNA, Cell, 2000, 第 1 作者 [2] 
參考資料